YX45
General
Type : Pyrrolidine, Pyrazole, Pyridine
Chemical_Nomenclature : 2-[4-chloro-1-(2-phenylethyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-1-(pyrrolidin-1-yl)ethan-1-one
Canonical SMILES : ClC1=CC=NC2=C1C(=N[N]2CCC3=CC=CC=C3)CC(=O)N4CCCC4
InChI : InChI=1S\/C20H21ClN4O\/c21-16-8-10-22-20-19(16)17(14-18(26)24-11-4-5-12-24)23-25(20)13-9-15-6-2-1-3-7-15\/h1-3,6-8,10H,4-5,9,11-14H2
InChIKey : HYMYLYRXAULJCL-UHFFFAOYSA-N
Other name(s) : A1CQR || A1CQU
Target
Families : YX45 ligand of proteins in family
S9N_PPCE_Peptidase_S9
Structure :
9Q5Y
Protein :
human-PREP
References (2)
| Title : Structure-Guided Optimization of 4-Chloro-Pyrazolopyridine Analogs for Covalent PREP Inhibition - Thakur_2026_J.Med.Chem__ |
| Author(s) : Thakur K , Fucci I , Pandian J , Suazo KF , Monteiro DCF , Yoo E |
| Ref : Journal of Medicinal Chemistry , : , 2026 |
| Abstract : |
| PubMedSearch : Thakur_2026_J.Med.Chem__ |
| PubMedID: 41512187 |
| Gene_locus related to this paper: human-PREPL |
| Title : Structure-Guided Optimization of 4-Chloro-Pyrazolopyridine Analogs for Covalent PREP Inhibition - Thakur_2026_J.Med.Chem__ |
| Author(s) : Thakur K , Fucci I , Pandian J , Suazo KF , Monteiro DCF , Yoo E |
| Ref : Journal of Medicinal Chemistry , : , 2026 |
| Abstract : |
| PubMedSearch : Thakur_2026_J.Med.Chem__ |
| PubMedID: 41512187 |
| Gene_locus related to this paper: human-PREPL |