Derivative of Desoxypeganine from plants of the Zygophyllaceae family. Inhibits both cholinesterases and monoamine oxydases.CID 442929 CID 197084 Linarine hydrochloride CID 667496 Vasicin [German]
Type : Not A\/B H target,Alkaloid,Natural_modified
Chemical_Nomenclature : (R)-1,2,3,9-Tetrahydropyrrolo(2,1-b)quinazolin-3-ol Pyrrolo(2,1-b)quinazolin-3-ol, 1,2,3,9-tetrahydro-
Canonical SMILES : C1CN2CC3=CC=CC=C3N=C2C1O.Cl || C1CN2CC3=CC=CC=C3N=C2C1O
InChI : InChI=1S\/C11H12N2O.ClH\/c14-10-5-6-13-7-8-3-1-2-4-9(8)12-11(10)13\;\/h1-4,10,14H,5-7H2\;1H\/t10-\;\/m0.\/s1 || InChI=1S\/C11H12N2O\/c14-10-5-6-13-7-8-3-1-2-4-9(8)12-11(10)13\/h1-4,10,14H,5-7H2\/t10-\/m1\/s1 || InChI=1S\/C11H12N2O\/c14-10-5-6-13-7-8-3-1-2-4-9(8)12-11(10)13\/h1-4,10,14H,5-7H2\/t10-\/m0\/s1
InChIKey : CSDQSAHJCAKJPT-PPHPATTJSA-N || YIICVSCAKJMMDJ-SNVBAGLBSA-N || YIICVSCAKJMMDJ-JTQLQIEISA-N
Other name(s) : Vasicine,ZINC00525717,Linarine hydrochloride
Title : Stereoselective glucuronidation metabolism, pharmacokinetics, anti-amnesic pharmacodynamics, and toxic properties of vasicine enantiomers in vitro and in vivo - Zhu_2018_Eur.J.Pharm.Sci_123_459 |
Author(s) : Zhu Y , Liu W , Qi S , Wang H , Wang Y , Deng G , Zhang Y , Li S , Ma C , Cheng X , Wang C |
Ref : Eur J Pharm Sci , 123 :459 , 2018 |
Abstract : Zhu_2018_Eur.J.Pharm.Sci_123_459 |
ESTHER : Zhu_2018_Eur.J.Pharm.Sci_123_459 |
PubMedSearch : Zhu_2018_Eur.J.Pharm.Sci_123_459 |
PubMedID: 30077712 |
Title : In vitro and in vivo metabolism and inhibitory activities of vasicine, a potent acetylcholinesterase and butyrylcholinesterase inhibitor - Liu_2015_PLoS.One_10_e0122366 |
Author(s) : Liu W , Shi X , Yang Y , Cheng X , Liu Q , Han H , Yang B , He C , Wang Y , Jiang B , Wang Z , Wang C |
Ref : PLoS ONE , 10 :e0122366 , 2015 |
Abstract : Liu_2015_PLoS.One_10_e0122366 |
ESTHER : Liu_2015_PLoS.One_10_e0122366 |
PubMedSearch : Liu_2015_PLoS.One_10_e0122366 |
PubMedID: 25849329 |
Title : Potent AChE and BChE inhibitors isolated from seeds of Peganum harmala Linn by a bioassay-guided fractionation - Yang_2015_J.Ethnopharmacol_168_279 |
Author(s) : Yang Y , Cheng X , Liu W , Chou G , Wang Z , Wang C |
Ref : J Ethnopharmacol , 168 :279 , 2015 |
Abstract : Yang_2015_J.Ethnopharmacol_168_279 |
ESTHER : Yang_2015_J.Ethnopharmacol_168_279 |
PubMedSearch : Yang_2015_J.Ethnopharmacol_168_279 |
PubMedID: 25862961 |
Title : [Pharmacological characteristics of desoxypeganine hydrochloride] - Tuliaganov_1986_Farmakol.Toksikol_49_37 |
Author(s) : Tuliaganov N , Sadritdinov FS , Suleimanova GA |
Ref : Farmakologiia i Toksikologiia , 49 :37 , 1986 |
Abstract : Tuliaganov_1986_Farmakol.Toksikol_49_37 |
ESTHER : Tuliaganov_1986_Farmakol.Toksikol_49_37 |
PubMedSearch : Tuliaganov_1986_Farmakol.Toksikol_49_37 |
PubMedID: 3720932 |
Array ( [id] => 4554 [inhibitor] => Peganine [type] => Array ( [0] => Not A\/B H target [1] => Alkaloid [2] => Natural_modified ) [other_name] => Array ( [0] => Vasicine [1] => ZINC00525717 [2] => Linarine hydrochloride ) [chemical_nomenclature] => (R)-1,2,3,9-Tetrahydropyrrolo(2,1-b)quinazolin-3-ol Pyrrolo(2,1-b)quinazolin-3-ol, 1,2,3,9-tetrahydro- [formula] => C11H12N2O [cas_number] => 6159-55-3 [mw] => 188 [pick_me_to_call] => display_script [kinetic_parameter] => [paper] => Zhu_2018_Eur.J.Pharm.Sci_123_459 || Tuliaganov_1986_Farmakol.Toksikol_49_37 || Liu_2015_PLoS.One_10_e0122366 || Yang_2015_J.Ethnopharmacol_168_279 [comment] => Derivative of Desoxypeganine from plants of the Zygophyllaceae family. Inhibits both cholinesterases and monoamine oxydases.CID 442929 CID 197084 Linarine hydrochloride CID 667496 Vasicin [German] [gene_locus] => [kin_inhibitor] => [cid] => 442929 || 197084 || 667496 [family] => ACHE || BCHE [inchikey] => CSDQSAHJCAKJPT-PPHPATTJSA-N || YIICVSCAKJMMDJ-SNVBAGLBSA-N || YIICVSCAKJMMDJ-JTQLQIEISA-N [canonicalsmiles] => C1CN2CC3=CC=CC=C3N=C2C1O.Cl || C1CN2CC3=CC=CC=C3N=C2C1O [inchi] => InChI=1S\/C11H12N2O.ClH\/c14-10-5-6-13-7-8-3-1-2-4-9(8)12-11(10)13\;\/h1-4,10,14H,5-7H2\;1H\/t10-\;\/m0.\/s1 || InChI=1S\/C11H12N2O\/c14-10-5-6-13-7-8-3-1-2-4-9(8)12-11(10)13\/h1-4,10,14H,5-7H2\/t10-\/m1\/s1 || InChI=1S\/C11H12N2O\/c14-10-5-6-13-7-8-3-1-2-4-9(8)12-11(10)13\/h1-4,10,14H,5-7H2\/t10-\/m0\/s1 [wikipedia] => Vasicine [iupharlig] => [structure] => [substrate] => [interact_gene_locus] => [mutation] => [comment2] => [extoxnet] => [news] => [theoretical_model] => )