IC50 2nM
Type : Adamantyl,Urea derivative,Indole
Chemical_Nomenclature : 1-(((3R,5R,7R)-Adamantan-1-yl)methyl)-3-(1-(4-isopropylbenzyl)-1H-indol-5-yl)urea
Canonical SMILES : C1C3CC2CC1(CC(C2)C3)CNC(=O)NC4=CC=C5C(=C4)C=C[N]5CC6=CC=C(C=C6)C(C)C
InChI : InChI=1S\/C30H37N3O\/c1-20(2)25-5-3-21(4-6-25)18-33-10-9-26-14-27(7-8-28(26)33)32-29(34)31-19-30-15-22-11-23(16-30)13-24(12-22)17-30\/h3-10,14,20,22-24H,11-13,15-19H2,1-2H3,(H2,31,32,34)
InChIKey : IMQMMJYORCVTET-UHFFFAOYSA-N
Other name(s) :
MW : 456.29
Formula : C30H37N3O
CAS_number :
PubChem :
UniChem : IMQMMJYORCVTET-UHFFFAOYSA-N
IUPHAR :
Wikipedia :
Families : Adamantyl-urea-Cpd28 ligand of proteins in family: Epoxide_hydrolase
Stucture :
Protein : human-EPHX2
Title : Design, Synthesis, and Pharmacological Characterization of a Potent Soluble Epoxide Hydrolase Inhibitor for the Treatment of Acute Pancreatitis - Musella_2023_J.Med.Chem__ |
Author(s) : Musella S , D'Avino D , Peltner LK , Di Sarno V , Cerqua I , Merciai F , Vestuto V , Ciaglia T , Smaldone G , Di Matteo F , Di Micco S , Napolitano V , Bifulco G , Pepe G , Sommella EM , Basilicata MG , Aquino G , Gomez-Monterrey IM , Campiglia P , Ostacolo C , Roviezzo F , Werz O , Rossi A , Bertamino A |
Ref : Journal of Medicinal Chemistry , : , 2023 |
Abstract : Musella_2023_J.Med.Chem__ |
ESTHER : Musella_2023_J.Med.Chem__ |
PubMedSearch : Musella_2023_J.Med.Chem__ |
PubMedID: 37334504 |
Gene_locus related to this paper: human-EPHX2 |