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Inhibitor Report for: Benzisothiazolinone-13

IC50 34.1 nM. Protects neuronal cells from oxidative stimuli and increased 2-AG levels in mouse brain


General
Type Thiazolinone, Sulfur Compound
Chemical_Nomenclature 2-(2-phenylethyl)-1,2-benzothiazol-3-one
Canonical SMILES C1=CC=C(C=C1)CCN2C(=O)C3=CC=CC=C3S2
InChI InChI=1S/C15H13NOS/c17-15-13-8-4-5-9-14(13)18-16(15)11-10-12-6-2-1-3-7-12/h1-9H,10-11H2
InChIKey VUMUTUGUKRGYGW-UHFFFAOYSA-N
Other name(s) BTZ-13 ; CHEMBL2391916 ; SCHEMBL6550955 ; BDBM50435396 ; 2-Phenethyl-1,2-benzisothiazol-3(2H)-one
________________________________________________________________________________________________
MW|255.3
Formula|C15H13NOS
CAS_number|
PubChem|9795048
UniChem|VUMUTUGUKRGYGW-UHFFFAOYSA-N
IUPHAR|
Wikipedia|

Target
Families | Benzisothiazolinone-13 ligand of proteins in family: Monoglyceridelipase_lysophospholip
Protein | human-MGLL

References:
Search PubMed for references concerning: Benzisothiazolinone-13
    Title: Benzisothiazolinone derivatives as potent allosteric monoacylglycerol lipase inhibitors that functionally mimic sulfenylation of regulatory cysteines
    Castelli R, Scalvini L, Vacondio F, Lodola A, Anselmi M, Vezzosi S, Carmi C, Bassi M, Ferlenghi F and Piomelli D <11 more author(s)>
    Ref: Journal of Medicinal Chemistry, 63:1261, 2020 : PubMed