1. Home
  2. Inhibitor
  3. EMP-TMB4

EMP-TMB4

Reactivators of organophosphate-inhibited ChEs give rise to phosphorylated oximes that reinhibit the enzyme. Reactivation of AChE inhibited by MEPQ with TMB4 will give EMP-TMB4

General

Type : Organophosphate,Phosphonylated oxime

Chemical_Nomenclature : ethoxyl methylphosphonyl-TMB4

Canonical SMILES : C1=[N+](C=CC(=C1)C(=NO)[H])CCC[N+]2=CC=C(C=C2)C(=NC[P](C)(OCC)=O)[H]

InChI : InChI=1S\/C19H26N4O3P\/c1-3-26-27(2,25)17-20-15-18-5-11-22(12-6-18)9-4-10-23-13-7-19(8-14-23)16-21-24\/h5-8,11-16H,3-4,9-10,17H2,1-2H3\/q+1\/p+1

InChIKey : DDIUMVSLOCHNNG-UHFFFAOYSA-O

Other name(s) : ethoxy methyl phosphonyl TMB-4,EMP-Trimedoxime

MW : 461.32

Formula : C19H27Cl2N403P

CAS_number :

PubChem :

UniChem : DDIUMVSLOCHNNG-UHFFFAOYSA-O

Target

Families : EMP-TMB4 ligand of proteins in family
ACHE

References (1)

Title : Phosphoryl oxime inhibition of acetylcholinesterase during oxime reactivation is prevented by edrophonium - Luo_1999_Biochemistry_38_9937
Author(s) : Luo C , Saxena A , Smith M , Garcia GE , Radic Z , Taylor P , Doctor BP
Ref : Biochemistry , 38 :9937 , 1999
Abstract : Luo_1999_Biochemistry_38_9937
ESTHER : Luo_1999_Biochemistry_38_9937
PubMedSearch : Luo_1999_Biochemistry_38_9937
PubMedID: 10433700 
Array
(
    [id] => 5088
    [inhibitor] => EMP-TMB4
    [type] => Array
        (
            [0] => Organophosphate
            [1] => Phosphonylated oxime
        )

    [other_name] => Array
        (
            [0] => ethoxy methyl phosphonyl TMB-4
            [1] => EMP-Trimedoxime
        )

    [chemical_nomenclature] => ethoxyl methylphosphonyl-TMB4
    [formula] => C19H27Cl2N403P
    [cas_number] => 
    [mw] => 461.32
    [pick_me_to_call] => display_script
    [kinetic_parameter] => 
    [paper] => Luo_1999_Biochemistry_38_9937
    [comment] => Reactivators of organophosphate-inhibited ChEs give rise to phosphorylated oximes that reinhibit the enzyme. Reactivation of AChE inhibited by MEPQ with TMB4 will give EMP-TMB4
    [gene_locus] => 
    [kin_inhibitor] => 
    [cid] => 
    [family] => ACHE
    [inchikey] => DDIUMVSLOCHNNG-UHFFFAOYSA-O
    [canonicalsmiles] => C1=[N+](C=CC(=C1)C(=NO)[H])CCC[N+]2=CC=C(C=C2)C(=NC[P](C)(OCC)=O)[H]
    [inchi] => InChI=1S\/C19H26N4O3P\/c1-3-26-27(2,25)17-20-15-18-5-11-22(12-6-18)9-4-10-23-13-7-19(8-14-23)16-21-24\/h5-8,11-16H,3-4,9-10,17H2,1-2H3\/q+1\/p+1
    [wikipedia] => 
    [iupharlig] => 
    [structure] => 
    [substrate] => 
    [interact_gene_locus] => 
    [mutation] => 
    [comment2] => 
    [extoxnet] => 
    [news] => 
    [theoretical_model] => 
)