Inhibitor

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Inhibitor Report for: OTFP

General
Type Trifluoro, Halo ketone, Sulfur Compound
Chemical_Nomenclature 1,1,1-trifluoro-3-octylsulfanylpropan-2-one
Canonical SMILES CCCCCCCCSCC(=O)C(F)(F)F
InChI InChI=1S/C11H19F3OS/c1-2-3-4-5-6-7-8-16-9-10(15)11(12,13)14/h2-9H2,1H3
InChIKey WMQHRXUKAYSPPK-UHFFFAOYSA-N
Other name(s) TFC ; CHEMBL89506 ; 3-Octylthio-1,1,1-trifluoro-2-propanone ; 2-Propanone,1,1,1-trifluoro-3-(octylthio)- ; 1,1,1-trifluoro-3-(octylsulfanyl)propan-2-one ; 1,1,1-trifluoro-3-(octylthio)acetone ; 3-octylthio-1,1,1-trifluoropropan-2-one
________________________________________________________________________________________________
MW|256.32
Formula|C11H19F3OS
CAS_number|89820-00-8
PubChem|146089
UniChem|WMQHRXUKAYSPPK-UHFFFAOYSA-N
IUPHAR|
Wikipedia|

Target
Families | OTFP ligand of proteins in family: Juvenile_hormone_esterase
Stucture | 1 structure: 2FJ0: Crystal Structure of Juvenile Hormone Esterase from Manduca sexta, with OTFP covalently attached
Protein | manse-jhest

References:
Search PubMed for references concerning: OTFP

2 more
    Title: Structural studies of a potent insect maturation inhibitor bound to the juvenile hormone esterase of Manduca sexta
    Wogulis M, Wheelock CE, Kamita SG, Hinton AC, Whetstone PA, Hammock BD, Wilson DK
    Ref: Biochemistry, 45:4045, 2006 : PubMed

            

    Title: Juvenile hormone esterase (JHE) from Tenebrio molitor: full-length cDNA sequence, in vitro expression, and characterization of the recombinant protein
    Hinton AC, Hammock BD
    Ref: Insect Biochemistry & Molecular Biology, 33:477, 2003 : PubMed

            

    Title: In vitro expression and biochemical characterization of juvenile hormone esterase from Manduca sexta
    Hinton AC, Hammock BD
    Ref: Insect Biochemistry & Molecular Biology, 33:317, 2003 : PubMed