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Inhibitor Report for: Scopoletin

Scopoletin is highly fluorescent. It is found in the root of plants in the genus Scopolia such as Scopolia carniolica and Scopolia japonica, in chicory, in Artemisia scoparia, in the roots and leaves of stinging nettle (Urtica dioica). It is a low inhibitor of cholinesterase, and serves as fluorophore building block of probes of the strigolactone receptors of plants. When oxidized, its fluorescence is strongly suppressed.


General
Type Coumarin, Natural
Chemical_Nomenclature 7-hydroxy-6-methoxychromen-2-one
Canonical SMILES COC1=C(C=C2C(=C1)C=CC(=O)O2)O
InChI InChI=1S/C10H8O4/c1-13-9-4-6-2-3-10(12)14-8(6)5-7(9)11/h2-5,11H,1H3
InChIKey RODXRVNMMDRFIK-UHFFFAOYSA-N
Other name(s) Gelseminic acid ; 7-Hydroxy-6-methoxy-2H-chromen-2-one ; 6-Methylesculetin ; CHEMBL71851 ; SCHEMBL147702 ; ZINC57733 ; CHEBI:17488 ; Murrayetin ; Scopoletine ; Scopoletol ; Escopoletin
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MW|192.17
Formula|C10H8O4
CAS_number|92-61-5
PubChem|5280460
UniChem|RODXRVNMMDRFIK-UHFFFAOYSA-N
IUPHAR|
Wikipedia|Scopoletin

Target

References:
Search PubMed for references concerning: Scopoletin

10 more
    Title: Scopoletin: Antiamyloidogenic, Anticholinesterase, and Neuroprotective Potential of a Natural Compound Present in Argyreia speciosa Roots by In Vitro and In Silico Study
    Kashyap P, Ram H, Shukla SD, Kumar S
    Ref: Neurosci Insights, 15:2633105520937693, 2020 : PubMed

            

    Title: Synthesis and anti-acetylcholinesterase activity of scopoletin derivatives
    Khunnawutmanotham N, Chimnoi N, Saparpakorn P, Techasakul S
    Ref: Bioorg Chem, 65:137, 2015 : PubMed

            

    Title: The coumarin scopoletin potentiates acetylcholine release from synaptosomes, amplifies hippocampal long-term potentiation and ameliorates anticholinergic- and age-impaired memory
    Hornick A, Lieb A, Vo NP, Rollinger JM, Stuppner H, Prast H
    Ref: Neuroscience, 197:280, 2011 : PubMed