UAMC-1110
IC50 FAP 0.0033 +/- 0.0004 microM very selective (>100 DPP4 1.8 +/- 0.2 PREP >100 DPP2 >12.5 DPP9)
General
Type : Quinoline,Carboxamide,Pyrrolidine,Cyanide
Chemical_Nomenclature : N-[2-[(2S)-2-cyano-4,4-difluoropyrrolidin-1-yl]-2-oxoethyl]quinoline-4-carboxamide
Canonical SMILES : C1C(N(CC1(F)F)C(=O)CNC(=O)C2=CC=NC3=CC=CC=C23)C#N
InChI : InChI=1S\/C17H14F2N4O2\/c18-17(19)7-11(8-20)23(10-17)15(24)9-22-16(25)13-5-6-21-14-4-2-1-3-12(13)14\/h1-6,11H,7,9-10H2,(H,22,25)\/t11-\/m0\/s1
InChIKey : PUOOCZVRHBHJRS-NSHDSACASA-N
Other name(s) : SP-13786,UAMC-01110,CHEMBL3233842
MW : 344.31
Formula : C17H14F2N4O2
CAS_number : 1448440-52-5
PubChem : 71621488
UniChem : PUOOCZVRHBHJRS-NSHDSACASA-N
IUPHAR :
Wikipedia :
Target
Families : UAMC-1110 ligand of proteins in family: DPP4N_Peptidase_S9
Stucture :
Protein : human-FAP
References (2)
| Title : Extended structure-activity relationship and pharmacokinetic investigation of (4-quinolinoyl)glycyl-2-cyanopyrrolidine inhibitors of fibroblast activation protein (FAP) - Jansen_2014_J.Med.Chem_57_3053 |
| Author(s) : Jansen K , Heirbaut L , Verkerk R , Cheng JD , Joossens J , Cos P , Maes L , Lambeir AM , De Meester I , Augustyns K , Van der Veken P |
| Ref : Journal of Medicinal Chemistry , 57 :3053 , 2014 |
| Abstract : Jansen_2014_J.Med.Chem_57_3053 |
| ESTHER : Jansen_2014_J.Med.Chem_57_3053 |
| PubMedSearch : Jansen_2014_J.Med.Chem_57_3053 |
| PubMedID: 24617858 |
| Title : Selective Inhibitors of Fibroblast Activation Protein (FAP) with a (4-Quinolinoyl)-glycyl-2-cyanopyrrolidine Scaffold - Jansen_2013_ACS.Med.Chem.Lett_4_491 |
| Author(s) : Jansen K , Heirbaut L , Cheng JD , Joossens J , Ryabtsova O , Cos P , Maes L , Lambeir AM , De Meester I , Augustyns K , Van der Veken P |
| Ref : ACS Med Chem Lett , 4 :491 , 2013 |
| Abstract : Jansen_2013_ACS.Med.Chem.Lett_4_491 |
| ESTHER : Jansen_2013_ACS.Med.Chem.Lett_4_491 |
| PubMedSearch : Jansen_2013_ACS.Med.Chem.Lett_4_491 |
| PubMedID: 24900696 |