Gene Locus : human-BCHE
Mode of mutation : Site directed mutagenesis
Disease :
Summary : Search for phosphotriesterase activity Phosphotriesterase activity Hydrolysis of OP Hydrolyses VX but not Soman Lockridge_1997_Biochemistry_36_786 Millard_1995_Biochemistry_34_15925 Millard_1998_Biochemistry_37_237 || OP-resistance Preserve activity, increase resistance to OP Broomfield_1995_5th.ChE.Meeting.Madras__169
AAA Change :
Allelic Variant :
Risk Factor :
Inhibitor :
Structure : 2XMB || 2XMC || 2XMD || 2XMG
Disease by interaction :
Interact Gene Locus :
Xenobiotic sensitivity :
Modification : Search for phosphotriesterase activity || OP-resistance
Torpedo_number : 119
Kinetic Parameter : Paraoxon_G117H_human-BCHE
News : No news
Comment :
p.G117H Gly117His (p.G145H Gly145His in primary sequence with 28 amino-acids signal peptide) Phosphotriesterase activity Hydrolysis of OP Hydrolyses VX but not Soman
| Title : Engineering Dynamic Surface Peptide Networks on ButyrylcholinesteraseG117H for Enhanced Organophosphosphorus Anticholinesterase Catalysis - Hester_2019_Chem.Res.Toxicol_32_1801 |
| Author(s) : Hester KP , Bhattarai K , Jiang H , Agarwal PK , Pope C |
| Ref : Chemical Research in Toxicology , 32 :1801 , 2019 |
| Abstract : |
| PubMedSearch : Hester_2019_Chem.Res.Toxicol_32_1801 |
| PubMedID: 31411024 |
| Title : Identification of Human Butyrylcholinesterase Organophosphate-Resistant Variants through a Novel Mammalian Enzyme Functional Screen - Zhang_2012_J.Pharmacol.Exp.Ther_343_673 |
| Author(s) : Zhang J , Chen S , Ralph EC , Dwyer MA , Cashman JR |
| Ref : Journal of Pharmacology & Experimental Therapeutics , 343 :673 , 2012 |
| Abstract : |
| PubMedSearch : Zhang_2012_J.Pharmacol.Exp.Ther_343_673 |
| PubMedID: 22956723 |
| Title : Hydrolysis of organophosphate compounds by mutant butyrylcholinesterase: a story of two histidines - Amitay_2011_Proteins_79_352 |
| Author(s) : Amitay M , Shurki A |
| Ref : Proteins , 79 :352 , 2011 |
| Abstract : |
| PubMedSearch : Amitay_2011_Proteins_79_352 |
| PubMedID: 21064131 |
| Title : Mutants of human butyrylcholinesterase with organophosphate hydrolase activity\; evidence that His117 is a general base catalyst for hydrolysis of echothiophate - Schopfer_2004_J.Med.Chem.Biol.Radiol.Def_2_1 |
| Author(s) : Schopfer LM , Boeck AT , Broomfield CA , Lockridge O |
| Ref : Journal of Medicinal Chemistryical Biology Radiol Def , 2 :1 , 2004 |
| Abstract : |
| PubMedSearch : Schopfer_2004_J.Med.Chem.Biol.Radiol.Def_2_1 |
| PubMedID: |
| Title : Protein engineering of a human enzyme that hydrolyzes V and G nerve agents: design, construction and characterization - Broomfield_1999_Chem.Biol.Interact_119-120_413 |
| Author(s) : Broomfield CA , Lockridge O , Millard CB |
| Ref : Chemico-Biological Interactions , 119-120 :413 , 1999 |
| Abstract : |
| PubMedSearch : Broomfield_1999_Chem.Biol.Interact_119-120_413 |
| PubMedID: 10421478 |
| Title : Organophosphorus acid anhydride hydrolase activity in human butyrylcholinesterase: synergy results in a somanase - Millard_1998_Biochemistry_37_237 |
| Author(s) : Millard CB , Lockridge O , Broomfield CA |
| Ref : Biochemistry , 37 :237 , 1998 |
| Abstract : |
| PubMedSearch : Millard_1998_Biochemistry_37_237 |
| PubMedID: 9425044 |
| Gene_locus related to this paper: human-BCHE |
| Title : A single amino acid substitution, Gly117His, confers phosphotriesterase (organophosphorus acid anhydride hydrolase) activity on human butyrylcholinesterase - Lockridge_1997_Biochemistry_36_786 |
| Author(s) : Lockridge O , Blong RM , Masson P , Froment MT , Millard CB , Broomfield CA |
| Ref : Biochemistry , 36 :786 , 1997 |
| Abstract : |
| PubMedSearch : Lockridge_1997_Biochemistry_36_786 |
| PubMedID: 9020776 |
| Title : Design and expression of organophosphorus acid anhydride hydrolase activity in human butyrylcholinesterase - Millard_1995_Biochemistry_34_15925 |
| Author(s) : Millard CB , Lockridge O , Broomfield CA |
| Ref : Biochemistry , 34 :15925 , 1995 |
| Abstract : |
| PubMedSearch : Millard_1995_Biochemistry_34_15925 |
| PubMedID: 8519749 |
| Title : Mutation of Human Butyrylcholinesterase Glycine 117 to Histidine Preserves Activity but Confers Resistance to Organophosphorus Inhibitors - |
| Author(s) : Broomfield CA , Millard CB , Lockridge O , Caviston TL |
| Ref : In Enzyme of the Cholinesterase Family - Proceedings of Fifth International Meeting on Cholinesterases , (Quinn, D.M., Balasubramanian, A.S., Doctor, B.P., Taylor, P., Eds) Plenum Publishing Corp. :169 , 1995 |
| PubMedID: |