W251L_luccu-E3aest7

Gene Locus : luccu-E3aest7

Mode of mutation : Natural mutant || Site directed mutagenesis

Disease :

Summary : OP-resistance mutant bowfly are resistant to OP insecticides, increases OP hydrolase activity (E3-Rmal Malathion and dimethyl OP) and alters kinetics for several carboxylester substrates Devonshire_2003_Pestic.Biochem.Physiol_76_1 || OP-resistance 2 G137D and 2 W251L haplotypes found in natural populations Newcomb_2005_J.Mol.Evol_60_207 || OP-resistance search for OP hydrolase and MCE activities Heidari_2004_Insect.Biochem.Mol.Biol_34_353 || Pyrethroids hydrolysis search for Pyrethroids hydrolysis activities Heidari_2005_Insect.Biochem.Mol.Biol_35_597 || Pyrethroids hydrolysis Hydrolysis of individual isomers of fluorogenic pyrethroid analogs by mutant carboxylesterases Devonshire_2007_Insect.Biochem.Mol.Biol_37_891 || OP-resistance search for OP hydrolase and MCE activities Campbell_1998_Insect.Biochem.Mol.Biol_28_139

AAA Change :

Allelic Variant :

Risk Factor :

Inhibitor :

Structure :

Disease by interaction :

Interact Gene Locus :

Xenobiotic sensitivity :

Modification : OP-resistance || Pyrethroids hydrolysis

Torpedo_number : 233

Kinetic Parameter : No kinetic parameter

News : No news

Comment : p.Trp251Leu . In Cui et al. called W271L in some insects in some insects enzymes tested by site directed mutagenesis: two lepidopteran species (Spodoptera litura, B. mori), two homopteran species (Aphis gossypii, Nilaparvata lugens), two coleopteran species (T. castaneum, Harmonia axyridis) and one hymenopteran species (A. mellifera)