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Mutation Report for: Y124A_human-ACHE

Y124A_human-ACHE
Gene_Locus|human-ACHE
Mode of mutation|Site directed mutagenesis
Amino Acid change|Y124A
Torpedo number|121
Summary|
Comment|p.Y124A Tyr124Ala (p.Y155A Tyr155Ala in primary sequence with 31 amino-acids signal peptide) Peripheral Anionic Site;low effect
Kinetic parameters|Acetylthiocholine_Y124A_human-ACHE,
BW284C51_Y124A_human-ACHE,
Decamethonium_Y124A_human-ACHE,
Edrophonium_Y124A_human-ACHE,
Hexamethonium_Y124A_human-ACHE,
HuperzineA_Y124A_human-ACHE,
Propidium_Y124A_human-ACHE,
Tacrine_Y124A_human-ACHE


References:
    Title: The 'aromatic patch' of three proximal residues in the human acetylcholinesterase active centre allows for versatile interaction modes with inhibitors
    Ariel N, Ordentlich A, Barak D, Bino T, Velan B, Shafferman A
    Ref: Biochemical Journal, 335:95, 1998 : PubMed

            

    Title: Molecular Aspects of Catalysis and of Allosteric Regulation of Aceytlcholinesterases
    Shafferman A, Ordentlich A, Barak D, Kronman C, Ariel N, Leitner M, Segall Y, Bromberg A, Reuveny S and Velan B <4 more author(s)>
    Ref: In Enzyme of the Cholinesterase Family - Proceedings of Fifth International Meeting on Cholinesterases, (Quinn, D.M., Balasubramanian, A.S., Doctor, B.P., Taylor, P., Eds) Plenum Publishing Corp.:189, 1995 : PubMed

            

    Title: Acetylcholinesterase peripheral anionic site degeneracy conferred by amino acid arrays sharing a common core
    Barak D, Kronman C, Ordentlich A, Ariel N, Bromberg A, Marcus D, Lazar A, Velan B, Shafferman A
    Ref: Journal of Biological Chemistry, 269:6296, 1994 : PubMed

            




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