El-Sayed_2005_Science_309_409

Reference

Title : The genome sequence of Trypanosoma cruzi, etiologic agent of Chagas disease - El-Sayed_2005_Science_309_409
Author(s) : El-Sayed NM , Myler PJ , Bartholomeu DC , Nilsson D , Aggarwal G , Tran AN , Ghedin E , Worthey EA , Delcher AL , Blandin G , Westenberger SJ , Caler E , Cerqueira GC , Branche C , Haas B , Anupama A , Arner E , Aslund L , Attipoe P , Bontempi E , Bringaud F , Burton P , Cadag E , Campbell DA , Carrington M , Crabtree J , Darban H , da Silveira JF , de Jong P , Edwards K , Englund PT , Fazelina G , Feldblyum T , Ferella M , Frasch AC , Gull K , Horn D , Hou L , Huang Y , Kindlund E , Klingbeil M , Kluge S , Koo H , Lacerda D , Levin MJ , Lorenzi H , Louie T , Machado CR , McCulloch R , McKenna A , Mizuno Y , Mottram JC , Nelson S , Ochaya S , Osoegawa K , Pai G , Parsons M , Pentony M , Pettersson U , Pop M , Ramirez JL , Rinta J , Robertson L , Salzberg SL , Sanchez DO , Seyler A , Sharma R , Shetty J , Simpson AJ , Sisk E , Tammi MT , Tarleton R , Teixeira S , Van Aken S , Vogt C , Ward PN , Wickstead B , Wortman J , White O , Fraser CM , Stuart KD , Andersson B
Ref : Science , 309 :409 , 2005
Abstract :

Whole-genome sequencing of the protozoan pathogen Trypanosoma cruzi revealed that the diploid genome contains a predicted 22,570 proteins encoded by genes, of which 12,570 represent allelic pairs. Over 50% of the genome consists of repeated sequences, such as retrotransposons and genes for large families of surface molecules, which include trans-sialidases, mucins, gp63s, and a large novel family (>1300 copies) of mucin-associated surface protein (MASP) genes. Analyses of the T. cruzi, T. brucei, and Leishmania major (Tritryp) genomes imply differences from other eukaryotes in DNA repair and initiation of replication and reflect their unusual mitochondrial DNA. Although the Tritryp lack several classes of signaling molecules, their kinomes contain a large and diverse set of protein kinases and phosphatases; their size and diversity imply previously unknown interactions and regulatory processes, which may be targets for intervention.

PubMedSearch : El-Sayed_2005_Science_309_409
PubMedID: 16020725
Gene_locus related to this paper: tryb2-q6h9e3 , tryb2-q6ha27 , tryb2-q38cd5 , tryb2-q38cd6 , tryb2-q38cd7 , tryb2-q38dc1 , tryb2-q38de4 , tryb2-q38ds6 , tryb2-q38dx1 , tryb2-q380z6 , tryb2-q382l4 , tryb2-q383a9 , tryb2-q386e3 , tryb2-q387r7 , tryb2-q388n1 , tryb2-q389w3 , trybr-PEPTB , trycr-q4cq28 , trycr-q4cq94 , trycr-q4cq95 , trycr-q4cq96 , trycr-q4cqq5 , trycr-q4csm0 , trycr-q4cwv3 , trycr-q4cx66 , trycr-q4cxr6 , trycr-q4cyc3 , trycr-q4cyc5 , trycr-q4cyf6 , trycr-q4czy3 , trycr-q4d1s2 , trycr-q4d2n1 , trycr-q4d3a2 , trycr-q4d3x3 , trycr-q4d3y4 , trycr-q4d6h1 , trycr-q4d8h8 , trycr-q4d8h9 , trycr-q4d8i0 , trycr-q4d786 , trycr-q4d975 , trycr-q4da08 , trycr-q4dab1 , trycr-q4dap6 , trycr-q4dap7 , trycr-q4dbm2 , trycr-q4dbn1 , trycr-q4ddw7 , trycr-q4de42 , trycr-q4dhn8 , trycr-q4dkk8 , trycr-q4dkk9 , trycr-q4dm56 , trycr-q4dp03 , trycr-q4dqa6 , trycr-q4dry8 , trycr-q4dt91 , trycr-q4dvl8 , trycr-q4dvp1 , trycr-q4dvp2 , trycr-q4dw34 , trycr-q4dwm3 , trycr-q4dy49 , trycr-q4dy82 , trycr-q4dzp6 , trycr-q4e3m8 , trycr-q4e4t5 , trycr-q4e5d1 , trycr-q4e5z2 , trycr-q6y3z8 , trycr-Q94795 , trycr-TCPO

Related information

Gene_locus tryb2-q6h9e3    tryb2-q6ha27    tryb2-q38cd5    tryb2-q38cd6    tryb2-q38cd7    tryb2-q38dc1    tryb2-q38de4    tryb2-q38ds6    tryb2-q38dx1    tryb2-q380z6    tryb2-q382l4    tryb2-q383a9    tryb2-q386e3    tryb2-q387r7    tryb2-q388n1    tryb2-q389w3    trybr-PEPTB    trycr-q4cq28    trycr-q4cq94    trycr-q4cq95    trycr-q4cq96    trycr-q4cqq5    trycr-q4csm0    trycr-q4cwv3    trycr-q4cx66    trycr-q4cxr6    trycr-q4cyc3    trycr-q4cyc5    trycr-q4cyf6    trycr-q4czy3    trycr-q4d1s2    trycr-q4d2n1    trycr-q4d3a2    trycr-q4d3x3    trycr-q4d3y4    trycr-q4d6h1    trycr-q4d8h8    trycr-q4d8h9    trycr-q4d8i0    trycr-q4d786    trycr-q4d975    trycr-q4da08    trycr-q4dab1    trycr-q4dap6    trycr-q4dap7    trycr-q4dbm2    trycr-q4dbn1    trycr-q4ddw7    trycr-q4de42    trycr-q4dhn8    trycr-q4dkk8    trycr-q4dkk9    trycr-q4dm56    trycr-q4dp03    trycr-q4dqa6    trycr-q4dry8    trycr-q4dt91    trycr-q4dvl8    trycr-q4dvp1    trycr-q4dvp2    trycr-q4dw34    trycr-q4dwm3    trycr-q4dy49    trycr-q4dy82    trycr-q4dzp6    trycr-q4e3m8    trycr-q4e4t5    trycr-q4e5d1    trycr-q4e5z2    trycr-q6y3z8    trycr-Q94795    trycr-TCPO
Gene_locus_frgt tryb2-q6h9e3    tryb2-q6ha27    tryb2-q38cd5    tryb2-q38cd6    tryb2-q38cd7    tryb2-q38dc1    tryb2-q38de4    tryb2-q38ds6    tryb2-q38dx1    tryb2-q380z6    tryb2-q382l4    tryb2-q383a9    tryb2-q386e3    tryb2-q387r7    tryb2-q388n1    tryb2-q389w3    trybr-PEPTB    trycr-q4cq28    trycr-q4cq94    trycr-q4cq95    trycr-q4cq96    trycr-q4cqq5    trycr-q4csm0    trycr-q4cwv3    trycr-q4cx66    trycr-q4cxr6    trycr-q4cyc3    trycr-q4cyc5    trycr-q4cyf6    trycr-q4czy3    trycr-q4d1s2    trycr-q4d2n1    trycr-q4d3a2    trycr-q4d3x3    trycr-q4d3y4    trycr-q4d6h1    trycr-q4d8h8    trycr-q4d8h9    trycr-q4d8i0    trycr-q4d786    trycr-q4d975    trycr-q4da08    trycr-q4dab1    trycr-q4dap6    trycr-q4dap7    trycr-q4dbm2    trycr-q4dbn1    trycr-q4ddw7    trycr-q4de42    trycr-q4dhn8    trycr-q4dkk8    trycr-q4dkk9    trycr-q4dm56    trycr-q4dp03    trycr-q4dqa6    trycr-q4dry8    trycr-q4dt91    trycr-q4dvl8    trycr-q4dvp1    trycr-q4dvp2    trycr-q4dw34    trycr-q4dwm3    trycr-q4dy49    trycr-q4dy82    trycr-q4dzp6    trycr-q4e3m8    trycr-q4e4t5    trycr-q4e5d1    trycr-q4e5z2    trycr-q6y3z8    trycr-Q94795    trycr-TCPO    trycr-q4crk1    trycr-q4cw86    trycr-q4cyc4    trycr-q4d995

Citations formats

El-Sayed NM, Myler PJ, Bartholomeu DC, Nilsson D, Aggarwal G, Tran AN, Ghedin E, Worthey EA, Delcher AL, Blandin G, Westenberger SJ, Caler E, Cerqueira GC, Branche C, Haas B, Anupama A, Arner E, Aslund L, Attipoe P, Bontempi E, Bringaud F, Burton P, Cadag E, Campbell DA, Carrington M, Crabtree J, Darban H, da Silveira JF, de Jong P, Edwards K, Englund PT, Fazelina G, Feldblyum T, Ferella M, Frasch AC, Gull K, Horn D, Hou L, Huang Y, Kindlund E, Klingbeil M, Kluge S, Koo H, Lacerda D, Levin MJ, Lorenzi H, Louie T, Machado CR, McCulloch R, McKenna A, Mizuno Y, Mottram JC, Nelson S, Ochaya S, Osoegawa K, Pai G, Parsons M, Pentony M, Pettersson U, Pop M, Ramirez JL, Rinta J, Robertson L, Salzberg SL, Sanchez DO, Seyler A, Sharma R, Shetty J, Simpson AJ, Sisk E, Tammi MT, Tarleton R, Teixeira S, Van Aken S, Vogt C, Ward PN, Wickstead B, Wortman J, White O, Fraser CM, Stuart KD, Andersson B (2005)
The genome sequence of Trypanosoma cruzi, etiologic agent of Chagas disease
Science 309 :409

El-Sayed NM, Myler PJ, Bartholomeu DC, Nilsson D, Aggarwal G, Tran AN, Ghedin E, Worthey EA, Delcher AL, Blandin G, Westenberger SJ, Caler E, Cerqueira GC, Branche C, Haas B, Anupama A, Arner E, Aslund L, Attipoe P, Bontempi E, Bringaud F, Burton P, Cadag E, Campbell DA, Carrington M, Crabtree J, Darban H, da Silveira JF, de Jong P, Edwards K, Englund PT, Fazelina G, Feldblyum T, Ferella M, Frasch AC, Gull K, Horn D, Hou L, Huang Y, Kindlund E, Klingbeil M, Kluge S, Koo H, Lacerda D, Levin MJ, Lorenzi H, Louie T, Machado CR, McCulloch R, McKenna A, Mizuno Y, Mottram JC, Nelson S, Ochaya S, Osoegawa K, Pai G, Parsons M, Pentony M, Pettersson U, Pop M, Ramirez JL, Rinta J, Robertson L, Salzberg SL, Sanchez DO, Seyler A, Sharma R, Shetty J, Simpson AJ, Sisk E, Tammi MT, Tarleton R, Teixeira S, Van Aken S, Vogt C, Ward PN, Wickstead B, Wortman J, White O, Fraser CM, Stuart KD, Andersson B (2005)
Science 309 :409