trybr-PEPTB

Trypanosoma brucei brucei, Trypanosoma evansi, Trypanosoma brucei gambiense, oligopeptidase b

Comment

Other strains: Trypanosoma brucei brucei, Trypanosoma evansi, Trypanosoma brucei gambiense (strain MHOM\/CI\/86\/DAL972)

Relationship

Family : S9N_PREPL_Peptidase_S9

Block : X

Position in NCBI Life Tree : Trypanosoma brucei

(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)

> cellular organisms N E > Eukaryota N E > Euglenozoa N E > Kinetoplastida N E > Trypanosomatidae N E > Trypanosoma N E > Trypanozoon N E > Trypanosoma brucei N E

Molecular evidence

No mutation

No kinetic

No disease

No substrate

Database

Sequence

Peptide

MQTERGPIAA HRPHEVVFGK VEGEDRGANP MDPPRRRVDP LFWLRDDNRA DPEVLAHLHL EKDYYEKRAV DIKDLAETIY QEHISHIEET DMSAPYVYDR FLYYTRDVKG LSYKLHCRVP AGKTPGEGED EEIVLDENKL AEGKSFCVVG CVAPAPPEHA LVAYSVDYCG DEVYSIRFVR DVVADKVEGT NGSVVWGPNA ECFFYITKDA SKRDNKVWRH IIGQPQSEDV CLYTDDDPLF SVGVGRSGDG KTLIICSMSS ETSESHLLDL RKGVKHNTLE MVRPREKGVR YTVEMHGTDT LIVLTNKDKC VNGKVVLTKR SAPTDWGTVL IPHDDKVTID DVAVFAKFAV LSGRRDGLTR VWTVRLGPDN LFSSATLKEL HFDEPVFTAH VVCSQMKTYD ASLLRLRYSS MTTPTVWYDE DVLSGERKVV KARKVGGGFE SKNYVCRREL ATAPDGTKVP ISLVYDTSID LKKPNPTMLY GYGSYGICIE PEFNSRFLPY VDRGMIYAIA HVRGGGEMGR TWYEVGGKYL TKRNTFMDFI ACAEHLISSG LTTPAQLSCE GRSAGGLLVG AVLNMRPDLF HVALAGVPFV DVMTTMCDPS IPLTTGEWEE WGNPNEYKFF DYMNSYSPID NVRAQDYPHL MIQAGLHDPR VAYWEPAKWA SKLRELKTDS NEVLLKMDLE SGHFSASDRY KYLRENAIQQ AFVLKHLNVR QLLRK

References (6)

Title : Crystal structures of Trypanosoma brucei oligopeptidase B broaden the paradigm of catalytic regulation in prolyl oligopeptidase family enzymes - Canning_2013_PLoS.One_8_e79349
Author(s) : Canning P , Rea D , Morty RE , Fulop V
Ref : PLoS ONE , 8 :e79349 , 2013
PubMedID: 24265767
Gene_locus related to this paper: trybr-PEPTB

Title : The genome sequence of Trypanosoma brucei gambiense, causative agent of chronic human african trypanosomiasis - Jackson_2010_PLoS.Negl.Trop.Dis_4_e658
Author(s) : Jackson AP , Sanders M , Berry A , McQuillan J , Aslett MA , Quail MA , Chukualim B , Capewell P , MacLeod A , Melville SE , Gibson W , Barry JD , Berriman M , Hertz-Fowler C
Ref : PLoS Negl Trop Dis , 4 :e658 , 2010
PubMedID: 20404998
Gene_locus related to this paper: tryb2-q6h9e3 , tryb2-q38cd5 , tryb2-q57u20 , tryb2-q57u43 , tryb2-q57xb0 , tryb2-q57y40 , tryb2-q389w3 , tryb2-q582c7 , tryb2-q582c8 , tryb9-c9zpb9 , tryb9-c9zu35 , tryb9-d0a9w2 , trybr-PEPTB

Title : Oligopeptidase B from Trypanosoma evansi. A parasite peptidase that inactivates atrial natriuretic factor in the bloodstream of infected hosts - Morty_2005_J.Biol.Chem_280_10925
Author(s) : Morty RE , Pelle R , Vadasz I , Uzcanga GL , Seeger W , Bubis J
Ref : Journal of Biological Chemistry , 280 :10925 , 2005
PubMedID: 15644339
Gene_locus related to this paper: trybr-PEPTB

Title : The genome sequence of Trypanosoma cruzi, etiologic agent of Chagas disease - El-Sayed_2005_Science_309_409
Author(s) : El-Sayed NM , Myler PJ , Bartholomeu DC , Nilsson D , Aggarwal G , Tran AN , Ghedin E , Worthey EA , Delcher AL , Blandin G , Westenberger SJ , Caler E , Cerqueira GC , Branche C , Haas B , Anupama A , Arner E , Aslund L , Attipoe P , Bontempi E , Bringaud F , Burton P , Cadag E , Campbell DA , Carrington M , Crabtree J , Darban H , da Silveira JF , de Jong P , Edwards K , Englund PT , Fazelina G , Feldblyum T , Ferella M , Frasch AC , Gull K , Horn D , Hou L , Huang Y , Kindlund E , Klingbeil M , Kluge S , Koo H , Lacerda D , Levin MJ , Lorenzi H , Louie T , Machado CR , McCulloch R , McKenna A , Mizuno Y , Mottram JC , Nelson S , Ochaya S , Osoegawa K , Pai G , Parsons M , Pentony M , Pettersson U , Pop M , Ramirez JL , Rinta J , Robertson L , Salzberg SL , Sanchez DO , Seyler A , Sharma R , Shetty J , Simpson AJ , Sisk E , Tammi MT , Tarleton R , Teixeira S , Van Aken S , Vogt C , Ward PN , Wickstead B , Wortman J , White O , Fraser CM , Stuart KD , Andersson B
Ref : Science , 309 :409 , 2005
PubMedID: 16020725
Gene_locus related to this paper: tryb2-q6h9e3 , tryb2-q6ha27 , tryb2-q38cd5 , tryb2-q38cd6 , tryb2-q38cd7 , tryb2-q38dc1 , tryb2-q38de4 , tryb2-q38ds6 , tryb2-q38dx1 , tryb2-q380z6 , tryb2-q382l4 , tryb2-q383a9 , tryb2-q386e3 , tryb2-q387r7 , tryb2-q388n1 , tryb2-q389w3 , trybr-PEPTB , trycr-q4cq28 , trycr-q4cq94 , trycr-q4cq95 , trycr-q4cq96 , trycr-q4cqq5 , trycr-q4csm0 , trycr-q4cwv3 , trycr-q4cx66 , trycr-q4cxr6 , trycr-q4cyc3 , trycr-q4cyc5 , trycr-q4cyf6 , trycr-q4czy3 , trycr-q4d1s2 , trycr-q4d2n1 , trycr-q4d3a2 , trycr-q4d3x3 , trycr-q4d3y4 , trycr-q4d6h1 , trycr-q4d8h8 , trycr-q4d8h9 , trycr-q4d8i0 , trycr-q4d786 , trycr-q4d975 , trycr-q4da08 , trycr-q4dab1 , trycr-q4dap6 , trycr-q4dap7 , trycr-q4dbm2 , trycr-q4dbn1 , trycr-q4ddw7 , trycr-q4de42 , trycr-q4dhn8 , trycr-q4dkk8 , trycr-q4dkk9 , trycr-q4dm56 , trycr-q4dp03 , trycr-q4dqa6 , trycr-q4dry8 , trycr-q4dt91 , trycr-q4dvl8 , trycr-q4dvp1 , trycr-q4dvp2 , trycr-q4dw34 , trycr-q4dwm3 , trycr-q4dy49 , trycr-q4dy82 , trycr-q4dzp6 , trycr-q4e3m8 , trycr-q4e4t5 , trycr-q4e5d1 , trycr-q4e5z2 , trycr-q6y3z8 , trycr-Q94795 , trycr-TCPO

Title : The genome of the African trypanosome Trypanosoma brucei - Berriman_2005_Science_309_416
Author(s) : Berriman M , Ghedin E , Hertz-Fowler C , Blandin G , Renauld H , Bartholomeu DC , Lennard NJ , Caler E , Hamlin NE , Haas B , Bohme U , Hannick L , Aslett MA , Shallom J , Marcello L , Hou L , Wickstead B , Alsmark UC , Arrowsmith C , Atkin RJ , Barron AJ , Bringaud F , Brooks K , Carrington M , Cherevach I , Chillingworth TJ , Churcher C , Clark LN , Corton CH , Cronin A , Davies RM , Doggett J , Djikeng A , Feldblyum T , Field MC , Fraser A , Goodhead I , Hance Z , Harper D , Harris BR , Hauser H , Hostetler J , Ivens A , Jagels K , Johnson D , Johnson J , Jones K , Kerhornou AX , Koo H , Larke N , Landfear S , Larkin C , Leech V , Line A , Lord A , MacLeod A , Mooney PJ , Moule S , Martin DM , Morgan GW , Mungall K , Norbertczak H , Ormond D , Pai G , Peacock CS , Peterson J , Quail MA , Rabbinowitsch E , Rajandream MA , Reitter C , Salzberg SL , Sanders M , Schobel S , Sharp S , Simmonds M , Simpson AJ , Tallon L , Turner CM , Tait A , Tivey AR , Van Aken S , Walker D , Wanless D , Wang S , White B , White O , Whitehead S , Woodward J , Wortman J , Adams MD , Embley TM , Gull K , Ullu E , Barry JD , Fairlamb AH , Opperdoes F , Barrell BG , Donelson JE , Hall N , Fraser CM , Melville SE , El-Sayed NM
Ref : Science , 309 :416 , 2005
PubMedID: 16020726
Gene_locus related to this paper: tryb2-q6h9e3 , tryb2-q6ha27 , tryb2-q38cd5 , tryb2-q38cd6 , tryb2-q38cd7 , tryb2-q38dc1 , tryb2-q38de4 , tryb2-q38ds6 , tryb2-q38dx1 , tryb2-q380z6 , tryb2-q382c1 , tryb2-q382l4 , tryb2-q383a9 , tryb2-q386e3 , tryb2-q387r7 , tryb2-q388n1 , tryb2-q389w3 , trybr-PEPTB , trycr-q4cq28 , trycr-q4cq94 , trycr-q4cq95 , trycr-q4cq96 , trycr-q4csm0 , trycr-q4cwv3 , trycr-q4cx66 , trycr-q4cxr6 , trycr-q4cyc5 , trycr-q4cyf6 , trycr-q4d3a2 , trycr-q4d3x3 , trycr-q4d3y4 , trycr-q4d6h1 , trycr-q4d8h8 , trycr-q4d8h9 , trycr-q4d8i0 , trycr-q4d786 , trycr-q4d975 , trycr-q4da08 , trycr-q4dap6 , trycr-q4dbm2 , trycr-q4dbn1 , trycr-q4ddw7 , trycr-q4de42 , trycr-q4dhn8 , trycr-q4dkk8 , trycr-q4dkk9 , trycr-q4dm56 , trycr-q4dqa6 , trycr-q4dt91 , trycr-q4dvp2 , trycr-q4dw34 , trycr-q4dwm3 , trycr-q4dy49 , trycr-q4dy82 , trycr-q4dzp6 , trycr-q4e3m8 , trycr-q4e4t5 , trycr-q4e5d1 , trycr-q4e5z2

Title : Oligopeptidase B from Trypanosoma brucei, a new member of an emerging subgroup of serine oligopeptidases - Morty_1999_J.Biol.Chem_274_26149
Author(s) : Morty RE , Lonsdale-Eccles JD , Morehead J , Caler EV , Mentele R , Auerswald EA , Coetzer TH , Andrews NW , Burleigh BA
Ref : Journal of Biological Chemistry , 274 :26149 , 1999
PubMedID: 10473566
Gene_locus related to this paper: leima-OPB , trybr-PEPTB