Kuroda_2005_Proc.Natl.Acad.Sci.U.S.A_102_13272

Reference

Title : Whole genome sequence of Staphylococcus saprophyticus reveals the pathogenesis of uncomplicated urinary tract infection - Kuroda_2005_Proc.Natl.Acad.Sci.U.S.A_102_13272
Author(s) : Kuroda M , Yamashita A , Hirakawa H , Kumano M , Morikawa K , Higashide M , Maruyama A , Inose Y , Matoba K , Toh H , Kuhara S , Hattori M , Ohta T
Ref : Proc Natl Acad Sci U S A , 102 :13272 , 2005
Abstract :

Staphylococcus saprophyticus is a uropathogenic Staphylococcus frequently isolated from young female outpatients presenting with uncomplicated urinary tract infections. We sequenced the whole genome of S. saprophyticus type strain ATCC 15305, which harbors a circular chromosome of 2,516,575 bp with 2,446 ORFs and two plasmids. Comparative genomic analyses with the strains of two other species, Staphylococcus aureus and Staphylococcus epidermidis, as well as experimental data, revealed the following characteristics of the S. saprophyticus genome. S. saprophyticus does not possess any virulence factors found in S. aureus, such as coagulase, enterotoxins, exoenzymes, and extracellular matrix-binding proteins, although it does have a remarkable paralog expansion of transport systems related to highly variable ion contents in the urinary environment. A further unique feature is that only a single ORF is predictable as a cell wall-anchored protein, and it shows positive hemagglutination and adherence to human bladder cell associated with initial colonization in the urinary tract. It also shows significantly high urease activity in S. saprophyticus. The uropathogenicity of S. saprophyticus can be attributed to its genome that is needed for its survival in the human urinary tract by means of novel cell wall-anchored adhesin and redundant uro-adaptive transport systems, together with urease.

PubMedSearch : Kuroda_2005_Proc.Natl.Acad.Sci.U.S.A_102_13272
PubMedID: 16135568
Gene_locus related to this paper: stas1-q4a0b8 , stas1-q4a0z3 , stas1-q4a018 , stas1-q4a076 , stas1-q4a169 , stas1-q49uw5 , stas1-q49vf8 , stas1-q49vg1 , stas1-q49vk0 , stas1-q49w07 , stas1-q49w20 , stas1-q49we3 , stas1-q49wg7 , stas1-q49ws3 , stas1-q49x95 , stas1-q49xp4 , stas1-q49yj4 , stas1-q49zd4 , stas1-q49zs7

Related information

Gene_locus stas1-q4a0b8    stas1-q4a0z3    stas1-q4a018    stas1-q4a076    stas1-q4a169    stas1-q49uw5    stas1-q49vf8    stas1-q49vg1    stas1-q49vk0    stas1-q49w07    stas1-q49w20    stas1-q49we3    stas1-q49wg7    stas1-q49ws3    stas1-q49x95    stas1-q49xp4    stas1-q49yj4    stas1-q49zd4    stas1-q49zs7
Gene_locus_frgt stas1-q4a0e0

Citations formats

Kuroda M, Yamashita A, Hirakawa H, Kumano M, Morikawa K, Higashide M, Maruyama A, Inose Y, Matoba K, Toh H, Kuhara S, Hattori M, Ohta T (2005)
Whole genome sequence of Staphylococcus saprophyticus reveals the pathogenesis of uncomplicated urinary tract infection
Proc Natl Acad Sci U S A 102 :13272

Kuroda M, Yamashita A, Hirakawa H, Kumano M, Morikawa K, Higashide M, Maruyama A, Inose Y, Matoba K, Toh H, Kuhara S, Hattori M, Ohta T (2005)
Proc Natl Acad Sci U S A 102 :13272