| Title : Novel multipotent tacrine-dihydropyridine hybrids with improved acetylcholinesterase inhibitory and neuroprotective activities as potential drugs for the treatment of Alzheimer's disease - Marco-Contelles_2006_J.Med.Chem_49_7607 |
| Author(s) : Marco-Contelles J , Leon R , de los Rios C , Guglietta A , Terencio J , Lopez MG , Garcia AG , Villarroya M |
| Ref : Journal of Medicinal Chemistry , 49 :7607 , 2006 |
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Abstract :
In this work we describe the synthesis and biological evaluation of the tacrine-1,4-dihydropyridine (DHP) hybrids (3-11). These multipotent molecules are the result of the juxtaposition of an acetylcholinesterase inhibitor (AChEI) such as tacrine (1) and a 1,4-DHP such as nimodipine (2). Compounds 3-11 are very selective and potent AChEIs and show an excellent neuroprotective profile and a moderate Ca2+ channel blockade effect. Consequently, these molecules are new potential drugs for the treatment of Alzheimer's disease. |
| PubMedSearch : Marco-Contelles_2006_J.Med.Chem_49_7607 |
| PubMedID: 17181144 |
Marco-Contelles J, Leon R, de los Rios C, Guglietta A, Terencio J, Lopez MG, Garcia AG, Villarroya M (2006)
Novel multipotent tacrine-dihydropyridine hybrids with improved acetylcholinesterase inhibitory and neuroprotective activities as potential drugs for the treatment of Alzheimer's disease
Journal of Medicinal Chemistry
49 :7607
Marco-Contelles J, Leon R, de los Rios C, Guglietta A, Terencio J, Lopez MG, Garcia AG, Villarroya M (2006)
Journal of Medicinal Chemistry
49 :7607