| Title : Polyfunctionalized alpha-Phenyl-tert-butyl(benzyl)nitrones: Multifunctional Antioxidants for Stroke Treatment - Diez-Iriepa_2022_Antioxidants.(Basel)_11_ |
| Author(s) : Diez-Iriepa D , Knez D , Gobec S , Iriepa I , de los Rios C , Bravo I , Lopez-Munoz F , Marco-Contelles J , Hadjipavlou-Litina D |
| Ref : Antioxidants (Basel) , 11 : , 2022 |
| Abstract : |
| PubMedSearch : Diez-Iriepa_2022_Antioxidants.(Basel)_11_ |
| PubMedID: 36139811 |
| Title : (+\/-)-BIGI-3h: Pentatarget-Directed Ligand combining Cholinesterase, Monoamine Oxidase, and Glycogen Synthase Kinase 3beta Inhibition with Calcium Channel Antagonism and Antiaggregating Properties for Alzheimer's Disease - Ismaili_2021_ACS.Chem.Neurosci__ |
| Author(s) : Ismaili L , Monnin J , Etievant A , Arribas RL , Viejo L , Refouvelet B , Soukup O , Janockova J , Hepnarova V , Korabecny J , Kucera T , Jun D , Andrys R , Musilek K , Baguet A , Garcia-Frutos EM , De Simone A , Andrisano V , Bartolini M , de los Rios C , Marco-Contelles J , Haffen E |
| Ref : ACS Chem Neurosci , : , 2021 |
| Abstract : |
| PubMedSearch : Ismaili_2021_ACS.Chem.Neurosci__ |
| PubMedID: 33797877 |
| Title : Tacrines for Alzheimer's disease therapy. III. The PyridoTacrines - de Los Rios_2019_Eur.J.Med.Chem_166_381 |
| Author(s) : de los Rios C , Marco-Contelles J |
| Ref : Eur Journal of Medicinal Chemistry , 166 :381 , 2019 |
| Abstract : |
| PubMedSearch : de Los Rios_2019_Eur.J.Med.Chem_166_381 |
| PubMedID: 30739821 |
| Title : New Dual Small Molecules for Alzheimer's Disease Therapy Combining Histamine H3 Receptor (H3R) Antagonism and Calcium Channels Blockade with Additional Cholinesterase Inhibition - Malek_2019_J.Med.Chem_62_11416 |
| Author(s) : Malek R , Arribas RL , Palomino-Antolin A , Totoson P , Demougeot C , Kobrlova T , Soukup O , Iriepa I , Moraleda I , Diez-Iriepa D , Godyn J , Panek D , Malawska B , Gluch-Lutwin M , Mordyl B , Siwek A , Chabchoub F , Marco-Contelles J , Kiec-Kononowicz K , Egea J , de los Rios C , Ismaili L |
| Ref : Journal of Medicinal Chemistry , 62 :11416 , 2019 |
| Abstract : |
| PubMedSearch : Malek_2019_J.Med.Chem_62_11416 |
| PubMedID: 31724859 |
| Title : Synthesis, pharmacological assessment, and molecular modeling of acetylcholinesterase\/butyrylcholinesterase inhibitors: effect against amyloid-beta-induced neurotoxicity - Silva_2013_ACS.Chem.Neurosci_4_547 |
| Author(s) : Silva D , Chioua M , Samadi A , Agostinho P , Garcao P , Lajarin-Cuesta R , de los Rios C , Iriepa I , Moraleda I , Gonzalez-Lafuente L , Mendes E , Perez C , Rodriguez-Franco MI , Marco-Contelles J , Carmo Carreiras M |
| Ref : ACS Chem Neurosci , 4 :547 , 2013 |
| Abstract : |
| PubMedSearch : Silva_2013_ACS.Chem.Neurosci_4_547 |
| PubMedID: 23379636 |
| Title : PP2A ligand ITH12246 protects against memory impairment and focal cerebral ischemia in mice - Lorrio_2013_ACS.Chem.Neurosci_4_1267 |
| Author(s) : Lorrio S , Romero A , Gonzalez-Lafuente L , Lajarin-Cuesta R , Martinez-Sanz FJ , Estrada M , Samadi A , Marco-Contelles J , Rodriguez-Franco MI , Villarroya M , Lopez MG , de los Rios C |
| Ref : ACS Chem Neurosci , 4 :1267 , 2013 |
| Abstract : |
| PubMedSearch : Lorrio_2013_ACS.Chem.Neurosci_4_1267 |
| PubMedID: 23763493 |
| Title : Multipotent MAO and cholinesterase inhibitors for the treatment of Alzheimer's disease: synthesis, pharmacological analysis and molecular modeling of heterocyclic substituted alkyl and cycloalkyl propargyl amine - Samadi_2012_Eur.J.Med.Chem_52_251 |
| Author(s) : Samadi A , de los Rios C , Bolea I , Chioua M , Iriepa I , Moraleda I , Bartolini M , Andrisano V , Galvez E , Valderas C , Unzeta M , Marco-Contelles J |
| Ref : Eur Journal of Medicinal Chemistry , 52 :251 , 2012 |
| Abstract : |
| PubMedSearch : Samadi_2012_Eur.J.Med.Chem_52_251 |
| PubMedID: 22503231 |
| Title : Cholinesterase inhibitors: a patent review (2007 - 2011) - de los Rios_2012_Expert.Opin.Ther.Pat_22_853 |
| Author(s) : de los Rios C |
| Ref : Expert Opin Ther Pat , 22 :853 , 2012 |
| Abstract : |
| PubMedSearch : de los Rios_2012_Expert.Opin.Ther.Pat_22_853 |
| PubMedID: 22764681 |
| Title : Synthesis, biological assessment and molecular modeling of 14-aryl-10,11,12,14-tetrahydro-9H-benzo[5,6]chromeno[2,3-b]quinolin-13-amines - Maalej_2011_Bioorg.Med.Chem.Lett_21_2384 |
| Author(s) : Maalej E , Chabchoub F , Samadi A , de los Rios C , Perona A , Morreale A , Marco-Contelles J |
| Ref : Bioorganic & Medicinal Chemistry Lett , 21 :2384 , 2011 |
| Abstract : |
| PubMedSearch : Maalej_2011_Bioorg.Med.Chem.Lett_21_2384 |
| PubMedID: 21411323 |
| Title : Synthesis, biological assessment and molecular modeling of new dihydroquinoline-3-carboxamides and dihydroquinoline-3-carbohydrazide derivatives as cholinesterase inhibitors, and Ca channel antagonists - Tomassoli_2011_Eur.J.Med.Chem_46_1 |
| Author(s) : Tomassoli I , Ismaili L , Pudlo M , de los Rios C , Soriano E , Colmena I , Gandia L , Rivas L , Samadi A , Marco-Contelles J , Refouvelet B |
| Ref : Eur Journal of Medicinal Chemistry , 46 :1 , 2011 |
| Abstract : |
| PubMedSearch : Tomassoli_2011_Eur.J.Med.Chem_46_1 |
| PubMedID: 21111515 |
| Title : Synthesis, biological evaluation, and molecular modeling of donepezil and N-[(5-(benzyloxy)-1-methyl-1H-indol-2-yl)methyl]-N-methylprop-2-yn-1-amine hybrids as new multipotent cholinesterase\/monoamine oxidase inhibitors for the treatment of Alzheimer's disease - Bolea_2011_J.Med.Chem_54_8251 |
| Author(s) : Bolea I , Juarez-Jimenez J , de los Rios C , Chioua M , Pouplana R , Luque FJ , Unzeta M , Marco-Contelles J , Samadi A |
| Ref : Journal of Medicinal Chemistry , 54 :8251 , 2011 |
| Abstract : |
| PubMedSearch : Bolea_2011_J.Med.Chem_54_8251 |
| PubMedID: 22023459 |
| Title : Synthesis and biological assessment of diversely substituted furo[2,3-b]quinolin-4-amine and pyrrolo[2,3-b]quinolin-4-amine derivatives, as novel tacrine analogues - Martins_2011_Eur.J.Med.Chem_46_6119 |
| Author(s) : Martins C , Carreiras MC , Leon R , de los Rios C , Bartolini M , Andrisano V , Iriepa I , Moraleda I , Galvez E , Garcia M , Egea J , Samadi A , Chioua M , Marco-Contelles J |
| Ref : Eur Journal of Medicinal Chemistry , 46 :6119 , 2011 |
| Abstract : |
| PubMedSearch : Martins_2011_Eur.J.Med.Chem_46_6119 |
| PubMedID: 22000936 |
| Title : Synthesis, biological assessment and molecular modeling of new multipotent MAO and cholinesterase inhibitors as potential drugs for the treatment of Alzheimer's disease - Samadi_2011_Eur.J.Med.Chem_46_4665 |
| Author(s) : Samadi A , Chioua M , Bolea I , de los Rios C , Iriepa I , Moraleda I , Bastida A , Esteban G , Unzeta M , Galvez E , Marco-Contelles J |
| Ref : Eur Journal of Medicinal Chemistry , 46 :4665 , 2011 |
| Abstract : |
| PubMedSearch : Samadi_2011_Eur.J.Med.Chem_46_4665 |
| PubMedID: 21669479 |
| Title : Effects of novel tacripyrines ITH12117 and ITH12118 on rat vas deferens contractions, calcium transients and cholinesterase activity - Pereira_2011_Eur.J.Pharmacol_660_411 |
| Author(s) : Pereira JD , Caricati-Neto A , Miranda-Ferreira R , Smaili SS , Godinho RO , de los Rios C , Leon R , Villaroya M , Samadi A , Marco-Contelles J , Jurkiewicz NH , Garcia AG , Jurkiewicz A |
| Ref : European Journal of Pharmacology , 660 :411 , 2011 |
| Abstract : |
| PubMedSearch : Pereira_2011_Eur.J.Pharmacol_660_411 |
| PubMedID: 21497158 |
| Title : 1,8-Naphthyridine derivatives as cholinesterases inhibitors and cell Ca2+ regulators, a multitarget strategy for Alzheimer's disease - Egea_2011_Curr.Top.Med.Chem_11_2807 |
| Author(s) : Egea J , de los Rios C |
| Ref : Curr Top Med Chem , 11 :2807 , 2011 |
| Abstract : |
| PubMedSearch : Egea_2011_Curr.Top.Med.Chem_11_2807 |
| PubMedID: 22039881 |
| Title : Molecular modelling, synthesis and acetylcholinesterase inhibition of ethyl 5-amino-2-methyl-6,7,8,9-tetrahydrobenzo[b][1,8]naphthyridine-3-carboxylate - Soriano_2010_Bioorg.Med.Chem.Lett_20_2950 |
| Author(s) : Soriano E , Samadi A , Chioua M , de los Rios C , Marco-Contelles J |
| Ref : Bioorganic & Medicinal Chemistry Lett , 20 :2950 , 2010 |
| Abstract : |
| PubMedSearch : Soriano_2010_Bioorg.Med.Chem.Lett_20_2950 |
| PubMedID: 20350807 |
| Title : Synthesis, inhibitory activity of cholinesterases, and neuroprotective profile of novel 1,8-naphthyridine derivatives - de Los Rios_2010_J.Med.Chem_53_5129 |
| Author(s) : de los Rios C , Egea J , Marco-Contelles J , Leon R , Samadi A , Iriepa I , Moraleda I , Galvez E , Garcia AG , Lopez MG , Villarroya M , Romero A |
| Ref : Journal of Medicinal Chemistry , 53 :5129 , 2010 |
| Abstract : |
| PubMedSearch : de Los Rios_2010_J.Med.Chem_53_5129 |
| PubMedID: 20575555 |
| Title : Tacripyrines, the first tacrine-dihydropyridine hybrids, as multitarget-directed ligands for the treatment of Alzheimer's disease - Marco-Contelles_2009_J.Med.Chem_52_2724 |
| Author(s) : Marco-Contelles J , Leon R , de los Rios C , Samadi A , Bartolini M , Andrisano V , Huertas O , Barril X , Luque FJ , Rodriguez-Franco MI , Lopez B , Lopez MG , Garcia AG , Carreiras Mdo C , Villarroya M |
| Ref : Journal of Medicinal Chemistry , 52 :2724 , 2009 |
| Abstract : |
| PubMedSearch : Marco-Contelles_2009_J.Med.Chem_52_2724 |
| PubMedID: 19374444 |
| Title : New tacrine-dihydropyridine hybrids that inhibit acetylcholinesterase, calcium entry, and exhibit neuroprotection properties - Leon_2008_Bioorg.Med.Chem_16_7759 |
| Author(s) : Leon R , de los Rios C , Marco-Contelles J , Huertas O , Barril X , Luque FJ , Lopez MG , Garcia AG , Villarroya M |
| Ref : Bioorganic & Medicinal Chemistry , 16 :7759 , 2008 |
| Abstract : |
| PubMedSearch : Leon_2008_Bioorg.Med.Chem_16_7759 |
| PubMedID: 18640842 |
| Title : Novel multipotent tacrine-dihydropyridine hybrids with improved acetylcholinesterase inhibitory and neuroprotective activities as potential drugs for the treatment of Alzheimer's disease - Marco-Contelles_2006_J.Med.Chem_49_7607 |
| Author(s) : Marco-Contelles J , Leon R , de los Rios C , Guglietta A , Terencio J , Lopez MG , Garcia AG , Villarroya M |
| Ref : Journal of Medicinal Chemistry , 49 :7607 , 2006 |
| Abstract : |
| PubMedSearch : Marco-Contelles_2006_J.Med.Chem_49_7607 |
| PubMedID: 17181144 |
| Title : ITH4012 (ethyl 5-amino-6,7,8,9-tetrahydro-2-methyl-4-phenylbenzol[1,8]naphthyridine-3-carboxylat e), a novel acetylcholinesterase inhibitor with calcium promotor and neuroprotective properties - Orozco_2004_J.Pharmacol.Exp.Ther_310_987 |
| Author(s) : Orozco C , de los Rios C , Arias E , Leon R , Garcia AG , Marco JL , Villarroya M , Lopez MG |
| Ref : Journal of Pharmacology & Experimental Therapeutics , 310 :987 , 2004 |
| Abstract : |
| PubMedSearch : Orozco_2004_J.Pharmacol.Exp.Ther_310_987 |
| PubMedID: 15111641 |
| Title : Synthesis, biological evaluation and molecular modelling of diversely functionalized heterocyclic derivatives as inhibitors of acetylcholinesterase\/butyrylcholinesterase and modulators of Ca2+ channels and nicotinic receptors - Marco_2004_Bioorg.Med.Chem_12_2199 |
| Author(s) : Marco JL , de los Rios C , Garcia AG , Villarroya M , Carreiras MC , Martins C , Eleuterio A , Morreale A , Orozco M , Luque FJ |
| Ref : Bioorganic & Medicinal Chemistry , 12 :2199 , 2004 |
| Abstract : |
| PubMedSearch : Marco_2004_Bioorg.Med.Chem_12_2199 |
| PubMedID: 15080920 |
| Title : Synthesis and Acetylcholinesterase\/Butyrylcholinesterase Inhibition Activity of 4-Amino-2, 3-diaryl-5, 6, 7, 8-tetrahydrofuro(and thieno)[2, 3-b]-quinolines, and 4-Amino-5, 6, 7, 8, 9-pentahydro-2, 3-diphenylcyclohepta[e]furo(and thieno)-[2, 3-b]pyridines - Marco_2002_Arch.Pharm.(Weinheim)_335_347 |
| Author(s) : Marco JL , de los Rios C , Carreiras MC , Banos JE , Badia A , Vivas NM |
| Ref : Arch Pharm (Weinheim) , 335 :347 , 2002 |
| Abstract : |
| PubMedSearch : Marco_2002_Arch.Pharm.(Weinheim)_335_347 |
| PubMedID: 12207285 |
| Title : Novel tacrine derivatives that block neuronal calcium channels - de los Rios_2002_Bioorg.Med.Chem_10_2077 |
| Author(s) : de los Rios C , Marco JL , Carreiras MD , Chinchon PM , Garcia AG , Villarroya M |
| Ref : Bioorganic & Medicinal Chemistry , 10 :2077 , 2002 |
| Abstract : |
| PubMedSearch : de los Rios_2002_Bioorg.Med.Chem_10_2077 |
| PubMedID: 11937366 |
| Title : Synthesis and acetylcholinesterase\/butyrylcholinesterase inhibition activity of new tacrine-like analogues - Marco_2001_Bioorg.Med.Chem_9_727 |
| Author(s) : Marco JL , de los Rios C , Carreiras MC , Banos JE , Badia A , Vivas NM |
| Ref : Bioorganic & Medicinal Chemistry , 9 :727 , 2001 |
| Abstract : |
| PubMedSearch : Marco_2001_Bioorg.Med.Chem_9_727 |
| PubMedID: 11310608 |