Type : Bispyridinium, Bisoxime, Oxime
Chemical_Nomenclature : oxo-[[1-[4-[2-(oxoazaniumylmethylidene)pyridin-1-yl]butyl]pyridin-2-ylidene]methyl]azanium
Canonical SMILES : C1=CC(=C[NH+]=O)N(C=C1)CCCCN2C=CC=CC2=C[NH+]=O
InChI : InChI=1S\/C16H18N4O2\/c21-17-13-15-7-1-3-9-19(15)11-5-6-12-20-10-4-2-8-16(20)14-18-22\/h1-4,7-10,13-14H,5-6,11-12H2\/p+2
InChIKey : XBWPUBVQNBIHRE-UHFFFAOYSA-P
Other name(s) : 1,4-bis(2-hydroxyiminomethylpyridinium) butane dibromide || CHEMBL1197954 || K-33 || AC1O9XJ0 || ZINC4480554 || K-033 || Oxo-[[1-[4-[2-(oxoazaniumylmethylidene)pyridin-1-yl]butyl]pyridin-2-ylidene]methyl]azanium
MW : 300.35
Formula : C16H20N4O2
CAS_number :
PubChem : 6793934
UniChem : XBWPUBVQNBIHRE-UHFFFAOYSA-P
Structure : No structure
Families : No family
Title : Mini review on blood-brain barrier penetration of pyridinium aldoximes - Kalasz_2014_J.Appl.Toxicol_2_141 |
Author(s) : Kalasz H , Nurulain SM , Veress G , Antus S , Darvas F , Adeghate E , Adem A , Hashemi F , Tekes K |
Ref : J Appl Toxicol , 2 :141 , 2014 |
Abstract : |
PubMedSearch : Kalasz_2014_J.Appl.Toxicol_2_141 |
PubMedID: 25291712 |
Title : In vitro reactivation kinetics of paraoxon- and DFP-inhibited electric eel AChE using mono- and bis-pyridinium oximes - Gupta_2014_Arch.Toxicol_88_381 |
Author(s) : Gupta B , Sharma R , Singh N , Kuca K , Acharya JR , Ghosh KK |
Ref : Archives of Toxicology , 88 :381 , 2014 |
Abstract : |
PubMedSearch : Gupta_2014_Arch.Toxicol_88_381 |
PubMedID: 24065055 |
Title : Reactivation of Tabun-inhibited Acetylcholinesterase Investigated by Two Oximes and Mutagenesis - Katalinic_2012_Croatica.Chem.Acta_85_209 |
Author(s) : Katalinic M , Kovarik Z |
Ref : Croatica Chemica Acta , 85 :209\ , 2012 |
Abstract : |
PubMedSearch : Katalinic_2012_Croatica.Chem.Acta_85_209 |
PubMedID: |
Title : In vitro and in vivo evaluation of pyridinium oximes: mode of interaction with acetylcholinesterase, effect on tabun- and soman-poisoned mice and their cytotoxicity - Calic_2006_Toxicology_219_85 |
Author(s) : Calic M , Vrdoljak AL , Radic B , Jelic D , Jun D , Kuca K , Kovarik Z |
Ref : Toxicology , 219 :85 , 2006 |
Abstract : |
PubMedSearch : Calic_2006_Toxicology_219_85 |
PubMedID: 16332406 |
Title : Five oximes (K-27, K-33, K-48, BI-6 and methoxime) in comparison with pralidoxime: in vitro reactivation of red blood cell acetylcholinesterase inhibited by paraoxon - Petroianu_2006_J.Appl.Toxicol_26_64 |
Author(s) : Petroianu GA , Arafat K , Kuca K , Kassa J |
Ref : J Appl Toxicol , 26 :64 , 2006 |
Abstract : |
PubMedSearch : Petroianu_2006_J.Appl.Toxicol_26_64 |
PubMedID: 16193529 |
Title : Five oximes (K-27, K-33, K-48, BI-6 and methoxime) in comparison with pralidoxime: survival in rats exposed to the organophosphate paraoxon - Petroianu_2006_J.Appl.Toxicol_26_262 |
Author(s) : Petroianu GA , Nurulain SM , Nagelkerke N , Al-Sultan MA , Kuca K , Kassa J |
Ref : J Appl Toxicol , 26 :262 , 2006 |
Abstract : |
PubMedSearch : Petroianu_2006_J.Appl.Toxicol_26_262 |
PubMedID: 16583462 |
Title : para- and ortho-Pyridinium aldoximes in reaction with acetylthiocholine - Sinko_2006_FEBS.Lett_580_3167 |
Author(s) : Sinko G , Calic M , Kovarik Z |
Ref : FEBS Letters , 580 :3167 , 2006 |
Abstract : |
PubMedSearch : Sinko_2006_FEBS.Lett_580_3167 |
PubMedID: 16684539 |
Title : The acute toxicity of acetylcholinesterase reactivators in mice in relation to their structure - Bartosova_2006_Neurotox.Res_9_291 |
Author(s) : Bartosova L , Kuca K , Kunesova G , Jun D |
Ref : Neurotox Res , 9 :291 , 2006 |
Abstract : |
PubMedSearch : Bartosova_2006_Neurotox.Res_9_291 |
PubMedID: 16782588 |
Title : Potency of new structurally different oximes to reactivate cyclosarin-inhibited human brain acetylcholinesterases - Kuca_2006_J.Enzyme.Inhib.Med.Chem_21_663 |
Author(s) : Kuca K , Cabal J , Jun D , Bajgar J , Hrabinova M |
Ref : J Enzyme Inhib Med Chem , 21 :663 , 2006 |
Abstract : |
PubMedSearch : Kuca_2006_J.Enzyme.Inhib.Med.Chem_21_663 |
PubMedID: 17252938 |
Title : Reactivation of sarin-inhibited pig brain acetylcholinesterase using oxime antidotes - Kuca_2006_J.Med.Toxicol_2_141 |
Author(s) : Kuca K , Jun D |
Ref : J Med Toxicol , 2 :141 , 2006 |
Abstract : |
PubMedSearch : Kuca_2006_J.Med.Toxicol_2_141 |
PubMedID: 18072133 |
Title : Pretreatment with pyridinium oximes improves antidotal therapy against tabun poisoning - Lucic_2006_Toxicology_228_41 |
Author(s) : Lucic Vrdoljak A , Calic M , Radic B , Zunec S , Jun D , Kuca K , Kovarik Z |
Ref : Toxicology , 228 :41 , 2006 |
Abstract : |
PubMedSearch : Lucic_2006_Toxicology_228_41 |
PubMedID: 16982122 |
Title : A comparison of the potency of newly developed oximes (K005, K027, K033, K048) and currently used oximes (pralidoxime, obidoxime, HI-6) to reactivate sarin-inhibited rat brain acetylcholinesterase by in vitro methods - Kuca_2005_J.Toxicol.Environ.Health.A_68_677 |
Author(s) : Kuca K , Cabal J , Kassa J |
Ref : J Toxicol Environ Health A , 68 :677 , 2005 |
Abstract : |
PubMedSearch : Kuca_2005_J.Toxicol.Environ.Health.A_68_677 |
PubMedID: 15901095 |
Title : New quaternary pyridine aldoximes as casual antidotes against nerve agents intoxications - Kuca_2005_Biomed.Pap.Med.Fac.Univ.Palacky.Olomouc.Czech.Repub_149_75 |
Author(s) : Kuca K , Bartosova L , Jun D , Patocka J , Cabal J , Kassa J , Kunesova G |
Ref : Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub , 149 :75 , 2005 |
Abstract : |
PubMedSearch : Kuca_2005_Biomed.Pap.Med.Fac.Univ.Palacky.Olomouc.Czech.Repub_149_75 |
PubMedID: 16170392 |
Title : Antidotal treatment of GF-agent intoxication in mice with bispyridinium oximes - Sevelova_2005_Toxicology_207_1 |
Author(s) : Sevelova L , Kuca K , Krejcova-Kunesova G |
Ref : Toxicology , 207 :1 , 2005 |
Abstract : |
PubMedSearch : Sevelova_2005_Toxicology_207_1 |
PubMedID: 15590116 |
Title : Comparison of ability of some oximes to reactivate sarin-inhibited brain acetylcholinesterase from different species - Jun_2005_Chem.Biol.Interact_157-158_385 |
Author(s) : Jun D , Kuca K , Cabal J , Bartosova L , Kunesova G , Kassa J |
Ref : Chemico-Biological Interactions , 157-158 :385 , 2005 |
Abstract : |
PubMedSearch : Jun_2005_Chem.Biol.Interact_157-158_385 |
PubMedID: 16429518 |
Title : In vitro reactivation of tabun-inhibited acetylcholinesterase using new oximes--K027, K005, K033 and K048 - Kuca_2004_Cent.Eur.J.Public.Health_12 Suppl_S59 |
Author(s) : Kuca K , Cabal J |
Ref : Central European Journal of Public Health , 12 Suppl :S59 , 2004 |
Abstract : |
PubMedSearch : Kuca_2004_Cent.Eur.J.Public.Health_12 Suppl_S59 |
PubMedID: 15141981 |
Title : A comparison of the efficacy of a bispyridinium oxime--1,4-bis-(2-hydroxyiminomethylpyridinium) butane dibromide and currently used oximes to reactivate sarin, tabun or cyclosarin-inhibited acetylcholinesterase by in vitro methods - Kuca_2004_Pharmazie_59_795 |
Author(s) : Kuca K , Cabal J , Kassa J |
Ref : Pharmazie , 59 :795 , 2004 |
Abstract : |
PubMedSearch : Kuca_2004_Pharmazie_59_795 |
PubMedID: 15544060 |
Title : In vitro reactivation of acetylcholinesterase inhibited by cyclosarin using bisquaternary pyridinium aldoximes K005, K033, K027 AND K048 - Kuca_2004_Acta.Medica.(Hradec.Kralove)_47_107 |
Author(s) : Kuca K , Sevelova-Bartosova L , Krejcova-Kunesova G |
Ref : Acta Medica (Hradec Kralove) , 47 :107 , 2004 |
Abstract : |
PubMedSearch : Kuca_2004_Acta.Medica.(Hradec.Kralove)_47_107 |
PubMedID: 15446359 |
Title : A comparison of the ability of a new bispyridinium oxime--1-(4-hydroxyiminomethylpyridinium)-4-(4-carbamoylpyridinium)butane dibromide and currently used oximes to reactivate nerve agent-inhibited rat brain acetylcholinesterase by in vitro methods - Kuca_2003_J.Enzyme.Inhib.Med.Chem_18_529 |
Author(s) : Kuca K , Kassa J |
Ref : J Enzyme Inhib Med Chem , 18 :529 , 2003 |
Abstract : |
PubMedSearch : Kuca_2003_J.Enzyme.Inhib.Med.Chem_18_529 |
PubMedID: 15008517 |