P2s~contrathion
General
Type : Oxime
Chemical_Nomenclature : pralidoxime methanesulphonate\; 2-hydroxyiminomethyl-N-methyl pyridinium methanesulphonate
Canonical SMILES : CN1C=CC=CC1=C[NH+]=O.CS(=O)(=O)[O-]
InChI : InChI=1S\/C7H8N2O.CH4O3S\/c1-9-5-3-2-4-7(9)6-8-10\;1-5(2,3)4\/h2-6H,1H3\;1H3,(H,2,3,4)\/b7-6+\;
InChIKey : WWZYJJGFUIAWNW-UHDJGPCESA-N
Other name(s) : Protopam || Contrathion || Pralidoxime mesylate || 2-Pam methanesulfonate || Pralidoxime methosulfate
Target
Structure : No structure
Families : No family
References (10)
| Title : Combined effect of organophosphorus hydrolase and oxime on the reactivation rate of diethylphosphoryl-acetylcholinesterase conjugates - Ashani_1998_Biochem.Pharmacol_55_159 |
| Author(s) : Ashani Y , Leader H , Rothschild N , Dosoretz C |
| Ref : Biochemical Pharmacology , 55 :159 , 1998 |
| Abstract : |
| PubMedSearch : Ashani_1998_Biochem.Pharmacol_55_159 |
| PubMedID: 9448738 |
| Title : Amino acid residues controlling reactivation of organophosphonyl conjugates of acetylcholinesterase by mono- and bisquaternary oximes - Ashani_1995_J.Biol.Chem_270_6370 |
| Author(s) : Ashani Y , Radic Z , Tsigelny I , Vellom DC , Pickering NA , Quinn DM , Doctor BP , Taylor P |
| Ref : Journal of Biological Chemistry , 270 :6370 , 1995 |
| Abstract : |
| PubMedSearch : Ashani_1995_J.Biol.Chem_270_6370 |
| PubMedID: 7890775 |
| Title : Cholinesterase reactivation in organophosphorus poisoned patients depends on the plasma concentrations of the oxime pralidoxime methylsulphate and of the organophosphate - Willems_1993_Arch.Toxicol_67_79 |
| Author(s) : Willems JL , De Bisschop HC , Verstraete AG , Declerck C , Christiaens Y , Vanscheeuwyck P , Buylaert WA , Vogelaers D , Colardyn F |
| Ref : Archives of Toxicology , 67 :79 , 1993 |
| Abstract : |
| PubMedSearch : Willems_1993_Arch.Toxicol_67_79 |
| PubMedID: 8481105 |
| Title : Long-term effects of the anticholinesterases sarin and soman on latencies of muscle action potentials in mouse diaphragm muscle - Smith_1993_J.Pharm.Pharmacol_45_176 |
| Author(s) : Smith AP |
| Ref : J Pharm Pharmacol , 45 :176 , 1993 |
| Abstract : |
| PubMedSearch : Smith_1993_J.Pharm.Pharmacol_45_176 |
| PubMedID: 8097774 |
| Title : Plasma concentrations of pralidoxime methylsulphate in organophosphorus poisoned patients - Willems_1992_Arch.Toxicol_66_260 |
| Author(s) : Willems JL , Langenberg JP , Verstraete AG , De Loose M , Vanhaesebroeck B , Goethals G , Belpaire FM , Buylaert WA , Vogelaers D , Colardyn F |
| Ref : Archives of Toxicology , 66 :260 , 1992 |
| Abstract : |
| PubMedSearch : Willems_1992_Arch.Toxicol_66_260 |
| PubMedID: 1514924 |
| Title : Side effects of therapeutic drugs against organophosphate poisoning - Wolthuis_1989_Neurotoxicol.Teratol_11_221 |
| Author(s) : Wolthuis OL , Philippens IH , Vanwersch RA |
| Ref : Neurotoxicology & Teratology , 11 :221 , 1989 |
| Abstract : |
| PubMedSearch : Wolthuis_1989_Neurotoxicol.Teratol_11_221 |
| PubMedID: 2666846 |
| Title : In vitro studies on the reactivation by oximes of phosphylated acetylcholinesterase--I. On the reactions of P2S with various organophosphates and the properties of the resultant phosphylated oximes - Harvey_1986_Biochem.Pharmacol_35_737 |
| Author(s) : Harvey B , Scott RP , Sellers DJ , Watts P |
| Ref : Biochemical Pharmacology , 35 :737 , 1986 |
| Abstract : |
| PubMedSearch : Harvey_1986_Biochem.Pharmacol_35_737 |
| PubMedID: 3954783 |
| Title : In vitro studies on the reactivation by oximes of phosphylated acetylcholinesterase--II. On the formation of O,O-diethyl phosphorylated AChE and O-ethyl methylphosphonylated AChE and their reactivation by PS2 - Harvey_1986_Biochem.Pharmacol_35_745 |
| Author(s) : Harvey B , Scott RP , Sellers DJ , Watts P |
| Ref : Biochemical Pharmacology , 35 :745 , 1986 |
| Abstract : |
| PubMedSearch : Harvey_1986_Biochem.Pharmacol_35_745 |
| PubMedID: 3954784 |
| Title : Profenofos insecticide bioactivation in relation to antidote action and the stereospecificity of acetylcholinesterase inhibition, reactivation, and aging - Glickman_1984_Toxicol.Appl.Pharmacol_73_16 |
| Author(s) : Glickman AH , Wing KD , Casida JE |
| Ref : Toxicology & Applied Pharmacology , 73 :16 , 1984 |
| Abstract : |
| PubMedSearch : Glickman_1984_Toxicol.Appl.Pharmacol_73_16 |
| PubMedID: 6710513 |
| Title : Behavioral toxicological assessment of oral pralidoxime methanesulfonate in the rat - Liu_1984_Neurobehavioral.Toxicology.&.Teratology_6_121 |
| Author(s) : Liu WF , Hu NW , Beaton JM |
| Ref : Neurobehav Toxicol Teratol , 6 :121 , 1984 |
| Abstract : |
| PubMedSearch : Liu_1984_Neurobehavioral.Toxicology.&.Teratology_6_121 |
| PubMedID: 6472556 |