Name : Torpedo californica acetylcholinesterase complexed with alkylene- linked bis-tacrine dimer (7 carbon linker)

Revelation date : 04-Sep-2006

Family : ACHE

Gene_locus : torca-ACHE

PDB file : ESTHER: header of PDB entry RCSB: Full entry

Brumshtein, B., Greenblatt, H.M., Wong, D.M., Pang, Y.P., Silman, I., Sussman, J.L.

Ligand : Inhibitor Bis7-tacrine Ligand in structure: Ligplot

References (1)

Title : Complexes of alkylene-linked tacrine dimers with Torpedo californica acetylcholinesterase: Binding of Bis5-tacrine produces a dramatic rearrangement in the active-site gorge - Rydberg_2006_J.Med.Chem_49_5491
Author(s) : Rydberg EH , Brumshtein B , Greenblatt HM , Wong DM , Shaya D , Williams LD , Carlier PR , Pang YP , Silman I , Sussman JL
Ref : Journal of Medicinal Chemistry , 49 :5491 , 2006
Abstract :
PubMedSearch : Rydberg_2006_J.Med.Chem_49_5491
PubMedID: 16942022
Gene_locus related to this paper: torca-ACHE

Representative scheme of Prolylcarboxypeptidase structure and an image from PDBsum server


PDB-Sum : 2CKM Previously Class, Architecture, Topology and Homologous superfamily - PDB-Sum server

FSSP : 2CKM Fold classification based on Structure-Structure alignment of Proteins - FSSP server

SCOP : 2CKM Structural Classification Of Protein - SCOP server

PROTEOPEDIA : 2CKM 3D, interactive encyclopedia of proteins - PROTEOPEDIA server