2CMF

Name : Torpedo californica acetylcholinesterase complexed with alkylene- linked bis-tacrine dimer (5 carbon linker)

Revelation date : 04-Sep-2006

Family : ACHE

PDB file : ESTHER: header of PDB entry RCSB: Full entry

Comment
Rydberg, E.H., Greenblatt, H.M., Wong, D.M., Pang, Y.P., Silman, I., Sussman, J.L

Ligand : Inhibitor Bis5-tacrine Ligand in structure: Ligplot

References (1)

Title : Complexes of alkylene-linked tacrine dimers with Torpedo californica acetylcholinesterase: Binding of Bis5-tacrine produces a dramatic rearrangement in the active-site gorge - Rydberg_2006_J.Med.Chem_49_5491

Author(s) : Rydberg EH , Brumshtein B , Greenblatt HM , Wong DM , Shaya D , Williams LD , Carlier PR , Pang YP , Silman I , Sussman JL

Ref : Journal of Medicinal Chemistry , 49 :5491 , 2006

Abstract :

PubMedSearch : Rydberg_2006_J.Med.Chem_49_5491

PubMedID: 16942022

Gene_locus related to this paper: torca-ACHE

Representative scheme of Prolylcarboxypeptidase structure and an image from PDBsum server

Databases

PDB-Sum : 2CMF Previously Class, Architecture, Topology and Homologous superfamily - PDB-Sum server

FSSP : 2CMF Fold classification based on Structure-Structure alignment of Proteins - FSSP server

SCOP : 2CMF Structural Classification Of Protein - SCOP server

PROTEOPEDIA : 2CMF 3D, interactive encyclopedia of proteins - PROTEOPEDIA server

2CMF

References (1)

1. Complexes of alkylene-linked tacrine dimers with Torpedo californica acetylcholinesterase: Binding of Bis5-tacrine produces a dramatic rearrangement in the active-site gorge - Rydberg_2006_J.Med.Chem_49_5491

Representative scheme of Prolylcarboxypeptidase structure and an image from PDBsum server

Databases