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Structure Report for: 6TR7

Name|Structure of the Wnt deacylase Notum in complex with N-[2-(5-fluoro-1H-indol-3-yl)ethyl]acetamide (6QCQ withdrawn)
Revelation date|08-Jan-2020
Family|Pectinacetylesterase-Notum: there are 695 genes in this family, 129 structure(s)
Gene_locus|human-NOTUM
PDB File|ESTHER: header of PDB entry RCSB: Full entry
Comment|
Zhao, Y., Jones, E.Y.
Ligand|Inhibitor: N-[2-(5-fluoro-1H-indol-3-yl)ethyl]acetamide Ligand in structure: Ligplot


Reference

    Title: Structural Analysis and Development of Notum Fragment Screening Hits
    Zhao Y, Mahy W, Willis NJ, Woodward HL, Steadman D, Bayle ED, Atkinson BN, Sipthorp J, Vecchia L and Jones EY <11 more author(s)>
    Ref: ACS Chem Neurosci, 13:2060, 2022 : PubMed

            

    Title: Structural characterisation of melatonin as an inhibitor of the Wnt deacylase Notum
    Zhao Y, Ren J, Hillier J, Jones M, Lu W, Jones EY
    Ref: J Pineal Res, :e12630, 2019 : PubMed

            



Representative scheme of Pectinacetylesterase-Notum structure and an image from PDBsum server

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Databases

PDB-Sum6TR7 Previously Class, Architecture, Topology and Homologous superfamily - PDB-Sum server
FSSP6TR7 Fold classification based on Structure-Structure alignment of Proteins - FSSP server
SCOP6TR7 Structural Classification Of Protein - SCOP server
PROTEOPEDIA6tr7 3D, interactive encyclopedia of proteins - PROTEOPEDIA server



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Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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