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Structure Report for: 7AYQ

Name|Crystal structure of DPP8 in complex with a 4-oxo-b-lactam based inhibitor, B114 (replaces 6T6T withdrawn)
Revelation date|30-Jun-2021
Family|DPP4N_Peptidase_S9: there are 829 genes in this family, 182 structure(s)
PDB File|ESTHER: header of PDB entry RCSB: Full entry
Fehr, L., Carvalho, L.A.R., Ross, B.H., Lum, K., Vieira, A.C., Kiefersauer, R., Geiss-Friedlander, R., Kaiser, M., Rodrigues, T., Lucas, S.D., Cravatt, B.F., Huber, R., Moreira, R.
Ligand|Inhibitor: 4-Oxo-beta-Lactam-B114 Ligand in structure: Ligplot Inhibitor: 4-Oxo-beta-Lactam-B114-closed Ligand in structure: Ligplot


    Title: Chemoproteomics-Enabled Identification of 4-Oxo-beta-Lactams as Inhibitors of Dipeptidyl Peptidases 8 and 9
    Carvalho LAR, Ross B, Fehr L, Bolgi O, Wohrle S, Lum KM, Podlesainski D, Vieira AC, Kiefersauer R and Moreira R <8 more author(s)>
    Ref: Angew Chem Int Ed Engl, :, 2022 : PubMed


Representative scheme of DPP4N_Peptidase_S9 structure and an image from PDBsum server

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PDB-Sum7AYQ Previously Class, Architecture, Topology and Homologous superfamily - PDB-Sum server
FSSP7AYQ Fold classification based on Structure-Structure alignment of Proteins - FSSP server
SCOP7AYQ Structural Classification Of Protein - SCOP server
PROTEOPEDIA7ayq 3D, interactive encyclopedia of proteins - PROTEOPEDIA server

Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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