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Substrate Report for: Eslicarbazepine-acetate

Eslicarbazepine acetate is the acetate ester of licarbazepine. An anticonvulsant, it is used as an adjunctive therapy for epilepsy by inhibiting repeated neuronal firing and stabilizing the inactivated state of voltage-gated sodium channels, thus preventing their return to the activated state during which seizure activity can occur. It is a dibenzoazepine, a carboxamide and a member of ureas.


General
Type Drug, Pro-Drug, Benzazepin, Carbamate, Acetate, Carboxamide
Chemical_Nomenclature [(5S)-11-carbamoyl-5,6-dihydrobenzo[b][1]benzazepin-5-yl] acetate
Canonical SMILES CC(=O)OC1CC2=CC=CC=C2N(C3=CC=CC=C13)C(=O)N
InChI InChI=1S/C17H16N2O3/c1-11(20)22-16-10-12-6-2-4-8-14(12)19(17(18)21)15-9-5-3-7-13(15)16/h2-9,16H,10H2,1H3,(H2,18,21)/t16-/m0/s1
InChIKey QIALRBLEEWJACW-INIZCTEOSA-N
Other name(s) Eslicarbazepine acetate ; BIA 2-093 ; Aptiom ; Zebinix
________________________________________________________________________________________________
MW|296.32
Formula|C17H16N2O3
CAS_number|236395-14-5
PubChem|179344
UniChem|QIALRBLEEWJACW-INIZCTEOSA-N
IUPHAR|
Wikipedia|

Target
Families | Eslicarbazepine-acetate ligand of proteins in family: Carb_B_Chordata, Arylacetamide_deacetylase
Protein | human-AADAC, human-CES1, human-CES2

References:
Search PubMed for references concerning: Eslicarbazepine-acetate
    Title: Role of human AADAC on hydrolysis of eslicarbazepine acetate and effects of AADAC genetic polymorphisms on hydrolase activity
    Hirosawa K, Fukami T, Tashiro K, Sakai Y, Kisui F, Nakano M, Nakajima M
    Ref: Drug Metabolism & Disposition: The Biological Fate of Chemicals, :, 2021 : PubMed

            

    Title: Steady-state plasma and cerebrospinal fluid pharmacokinetics and tolerability of eslicarbazepine acetate and oxcarbazepine in healthy volunteers
    Nunes T, Rocha JF, Falcao A, Almeida L, Soares-da-Silva P
    Ref: Epilepsia, 54:108, 2013 : PubMed

            

    Title: A novel polymorphic allele of human arylacetamide deacetylase leads to decreased enzyme activity
    Shimizu M, Fukami T, Kobayashi Y, Takamiya M, Aoki Y, Nakajima M, Yokoi T
    Ref: Drug Metabolism & Disposition: The Biological Fate of Chemicals, 40:1183, 2012 : PubMed