human-AADAC

Homo sapiens (Human) arylacetamide deacetylase

Comment

Arylacetamide deacetylase displays cellular triglyceride lipase activity in liver, increases the levels of intracellular fatty acids derived from the hydrolysis of newly formed triglyceride stores and plays a role in very low-density lipoprotein assembly. Displays serine esterase activity in liver. Deacetylates a variety of arylacetamide substrates, including xenobiotic compounds and procarcinogens, converting them to the primary arylamide compounds and increasing their toxicity

Relationship

Family : Arylacetamide_deacetylase

Block : H

Position in NCBI Life Tree : Homo sapiens

(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)

> cellular organisms N E > Eukaryota N E > Opisthokonta N E > Metazoa N E > Eumetazoa N E > Bilateria N E > Deuterostomia N E > Chordata N E > Craniata N E > Vertebrata N E > Gnathostomata N E > Teleostomi N E > Euteleostomi N E > Sarcopterygii N E > Dipnotetrapodomorpha N E > Tetrapoda N E > Amniota N E > Mammalia N E > Theria N E > Eutheria N E > Boreoeutheria N E > Euarchontoglires N E > Primates N E > Haplorrhini N E > Simiiformes N E > Catarrhini N E > Hominoidea N E > Hominidae N E > Homininae N E > Homo N E > Homo sapiens N E

Molecular evidence

Database

Sequence

Peptide

MGRKSLYLLI VGILIAYYIY TPLPDNVEEP WRMMWINAHL KTIQNLATFV ELHGSSIFMD SFKVVGSFDE VPPTSDENVT VTETKFNNIL VRVYVPKRKS EALRRGLFYI HGGGWCVGSA ALSGYDLLSR WTADRLDAVV VSTNYRLAPK YHFPIQFEDV YNALRWFLRK KVLAKYGVNP ERIGISGDSA GGNLAAAVTQ QLLDDPDVKI KLKIQSLIYP ALQPLDVDLP SYQENSNFLF LSKSLMVRFW SEYFTTDRSL EKAMLSRQHV PVESSHLFKF INWSSLLPER FIKGHVYNNP NYGSSELAKK YPGFLDVRAA PLLADDNKLR GLPLTYVITC QYDLLRDDGL MYVTRLRNTG VQVTHNHVED GFHGAFSFLG LKISHRLINQ YIEWLKENL

References (20)

Title : Role of carboxylesterase and arylacetamide deacetylase in drug metabolism, physiology, and pathology - Nagaoka_2024_Biochem.Pharmacol__116128
Author(s) : Nagaoka M , Sakai Y , Nakajima M , Fukami T
Ref : Biochemical Pharmacology , :116128 , 2024
PubMedID: 38492781
Gene_locus related to this paper: human-AADAC , human-CES1 , human-CES2

Title : Effect of Genetic Variations in Drug-Metabolizing Enzymes and Drug Transporters on the Pharmacokinetics of Rifamycins: A Systematic Review - Sileshi_2022_Pharmgenomics.Pers.Med_15_561
Author(s) : Sileshi T , Mekonen G , Makonnen E , Aklillu E
Ref : Pharmgenomics Pers Med , 15 :561 , 2022
PubMedID: 35693129
Gene_locus related to this paper: human-AADAC

Title : Impact of AADAC gene expression on prognosis in patients with Borrmann type III advanced gastric cancer - Wang_2022_BMC.Cancer_22_635
Author(s) : Wang Y , Fang T , Yin X , Zhang L , Zhang X , Zhang D , Zhang Y , Wang X , Wang H , Xue Y
Ref : BMC Cancer , 22 :635 , 2022
PubMedID: 35681154
Gene_locus related to this paper: human-AADAC

Title : Role of human AADAC on hydrolysis of eslicarbazepine acetate and effects of AADAC genetic polymorphisms on hydrolase activity - Hirosawa_2021_Drug.Metab.Dispos__
Author(s) : Hirosawa K , Fukami T , Tashiro K , Sakai Y , Kisui F , Nakano M , Nakajima M
Ref : Drug Metabolism & Disposition: The Biological Fate of Chemicals , : , 2021
PubMedID: 33446525
Gene_locus related to this paper: human-AADAC

Title : Allelic and genotypic frequencies of NAT2, CYP2E1, and AADAC genes in a cohort of Peruvian tuberculosis patients - Levano_2021_Mol.Genet.Genomic.Med_9_e1764
Author(s) : Levano KS , Jaramillo-Valverde L , Tarazona DD , Sanchez C , Capristano S , Vasquez-Loarte T , Solari L , Mendoza-Ticona A , Soto A , Rojas C , Zegarra-Chaponan R , Guio H
Ref : Mol Genet Genomic Med , 9 :e1764 , 2021
PubMedID: 34510815
Gene_locus related to this paper: human-AADAC

Title : A Population Pharmacokinetic Analysis Shows that Arylacetamide Deacetylase (AADAC) Gene Polymorphism and HIV Infection Affect the Exposure of Rifapentine - Francis_2019_Antimicrob.Agents.Chemother_63_e01964
Author(s) : Francis J , Zvada SP , Denti P , Hatherill M , Charalambous S , Mungofa S , Dawson R , Dorman S , Gupte N , Wiesner L , Jindani A , Harrison TS , Olagunju A , Egan D , Owen A , McIlleron HM
Ref : Antimicrobial Agents & Chemotherapy , 63 : , 2019
PubMedID: 30670438
Gene_locus related to this paper: human-AADAC

Title : Comparison of substrate specificity among human arylacetamide deacetylase and carboxylesterases - Fukami_2015_Eur.J.Pharm.Sci_78_47
Author(s) : Fukami T , Kariya M , Kurokawa T , Iida A , Nakajima M
Ref : Eur J Pharm Sci , 78 :47 , 2015
PubMedID: 26164127
Gene_locus related to this paper: human-AADAC , human-CES1 , human-CES2

Title : Screening of specific inhibitors for human carboxylesterases or arylacetamide deacetylase - Shimizu_2014_Drug.Metab.Dispos_42_1103
Author(s) : Shimizu M , Fukami T , Nakajima M , Yokoi T
Ref : Drug Metabolism & Disposition: The Biological Fate of Chemicals , 42 :1103 , 2014
PubMedID: 24751575
Gene_locus related to this paper: human-AADAC , human-CES1 , human-CES2

Title : N-Glycosylation during translation is essential for human arylacetamide deacetylase enzyme activity - Muta_2014_Biochem.Pharmacol_87_352
Author(s) : Muta K , Fukami T , Nakajima M , Yokoi T
Ref : Biochemical Pharmacology , 87 :352 , 2014
PubMedID: 24125761
Gene_locus related to this paper: human-AADAC

Title : Steady-state plasma and cerebrospinal fluid pharmacokinetics and tolerability of eslicarbazepine acetate and oxcarbazepine in healthy volunteers - Nunes_2013_Epilepsia_54_108
Author(s) : Nunes T , Rocha JF , Falcao A , Almeida L , Soares-da-Silva P
Ref : Epilepsia , 54 :108 , 2013
PubMedID: 22812691
Gene_locus related to this paper: human-AADAC

Title : Arylacetamide deacetylase: a novel host factor with important roles in the lipolysis of cellular triacylglycerol stores, VLDL assembly and HCV production - Nourbakhsh_2013_J.Hepatol_59_336
Author(s) : Nourbakhsh M , Douglas DN , Pu CH , Lewis JT , Kawahara T , Lisboa LF , Wei E , Asthana S , Quiroga AD , Law LM , Chen C , Addison WR , Nelson R , Houghton M , Lehner R , Kneteman NM
Ref : Journal of Hepatology , 59 :336 , 2013
PubMedID: 23542347
Gene_locus related to this paper: human-AADAC

Title : Species differences in tissue distribution and enzyme activities of arylacetamide deacetylase in human, rat, and mouse - Kobayashi_2012_Drug.Metab.Dispos_40_671
Author(s) : Kobayashi Y , Fukami T , Nakajima A , Watanabe A , Nakajima M , Yokoi T
Ref : Drug Metabolism & Disposition: The Biological Fate of Chemicals , 40 :671 , 2012
PubMedID: 22207054
Gene_locus related to this paper: human-AADAC , mouse-aryla , ratno-aryla

Title : A novel polymorphic allele of human arylacetamide deacetylase leads to decreased enzyme activity - Shimizu_2012_Drug.Metab.Dispos_40_1183
Author(s) : Shimizu M , Fukami T , Kobayashi Y , Takamiya M , Aoki Y , Nakajima M , Yokoi T
Ref : Drug Metabolism & Disposition: The Biological Fate of Chemicals , 40 :1183 , 2012
PubMedID: 22415931
Gene_locus related to this paper: human-AADAC

Title : Human arylacetamide deacetylase is responsible for deacetylation of rifamycins: rifampicin, rifabutin, and rifapentine - Nakajima_2011_Biochem.Pharmacol_82_1747
Author(s) : Nakajima A , Fukami T , Kobayashi Y , Watanabe A , Nakajima M , Yokoi T
Ref : Biochemical Pharmacology , 82 :1747 , 2011
PubMedID: 21856291
Gene_locus related to this paper: human-AADAC

Title : Human arylacetamide deacetylase is a principal enzyme in flutamide hydrolysis - Watanabe_2009_Drug.Metab.Dispos_37_1513
Author(s) : Watanabe A , Fukami T , Nakajima M , Takamiya M , Aoki Y , Yokoi T
Ref : Drug Metabolism & Disposition: The Biological Fate of Chemicals , 37 :1513 , 2009
PubMedID: 19339378
Gene_locus related to this paper: human-AADAC

Title : Human carboxylesterases and their role in xenobiotic and endobiotic metabolism - Ross_2007_J.Biochem.Mol.Toxicol_21_187
Author(s) : Ross MK , Crow JA
Ref : J Biochem Mol Toxicol , 21 :187 , 2007
PubMedID: 17936933
Gene_locus related to this paper: human-AADAC

Title : The DNA sequence, annotation and analysis of human chromosome 3 - Muzny_2006_Nature_440_1194
Author(s) : Muzny DM , Scherer SE , Kaul R , Wang J , Yu J , Sudbrak R , Buhay CJ , Chen R , Cree A , Ding Y , Dugan-Rocha S , Gill R , Gunaratne P , Harris RA , Hawes AC , Hernandez J , Hodgson AV , Hume J , Jackson A , Khan ZM , Kovar-Smith C , Lewis LR , Lozado RJ , Metzker ML , Milosavljevic A , Miner GR , Morgan MB , Nazareth LV , Scott G , Sodergren E , Song XZ , Steffen D , Wei S , Wheeler DA , Wright MW , Worley KC , Yuan Y , Zhang Z , Adams CQ , Ansari-Lari MA , Ayele M , Brown MJ , Chen G , Chen Z , Clendenning J , Clerc-Blankenburg KP , Davis C , Delgado O , Dinh HH , Dong W , Draper H , Ernst S , Fu G , Gonzalez-Garay ML , Garcia DK , Gillett W , Gu J , Hao B , Haugen E , Havlak P , He X , Hennig S , Hu S , Huang W , Jackson LR , Jacob LS , Kelly SH , Kube M , Levy R , Li Z , Liu B , Liu J , Liu W , Lu J , Maheshwari M , Nguyen BV , Okwuonu GO , Palmeiri A , Pasternak S , Perez LM , Phelps KA , Plopper FJ , Qiang B , Raymond C , Rodriguez R , Saenphimmachak C , Santibanez J , Shen H , Shen Y , Subramanian S , Tabor PE , Verduzco D , Waldron L , Wang Q , Williams GA , Wong GK , Yao Z , Zhang J , Zhang X , Zhao G , Zhou J , Zhou Y , Nelson D , Lehrach H , Reinhardt R , Naylor SL , Yang H , Olson M , Weinstock G , Gibbs RA
Ref : Nature , 440 :1194 , 2006
PubMedID: 16641997
Gene_locus related to this paper: human-AADAC , human-AADACL2 , human-ABHD5 , human-ABHD6 , human-ABHD10 , human-ABHD14A , human-APEH , human-BCHE , human-CIB , human-LIPH , human-MGLL , human-NLGN1 , human-PLA1A

Title : The sequence of the human genome - Venter_2001_Science_291_1304
Author(s) : Venter JC , Adams MD , Myers EW , Li PW , Mural RJ , Sutton GG , Smith HO , Yandell M , Evans CA , Holt RA , Gocayne JD , Amanatides P , Ballew RM , Huson DH , Wortman JR , Zhang Q , Kodira CD , Zheng XH , Chen L , Skupski M , Subramanian G , Thomas PD , Zhang J , Gabor Miklos GL , Nelson C , Broder S , Clark AG , Nadeau J , McKusick VA , Zinder N , Levine AJ , Roberts RJ , Simon M , Slayman C , Hunkapiller M , Bolanos R , Delcher A , Dew I , Fasulo D , Flanigan M , Florea L , Halpern A , Hannenhalli S , Kravitz S , Levy S , Mobarry C , Reinert K , Remington K , Abu-Threideh J , Beasley E , Biddick K , Bonazzi V , Brandon R , Cargill M , Chandramouliswaran I , Charlab R , Chaturvedi K , Deng Z , Di Francesco V , Dunn P , Eilbeck K , Evangelista C , Gabrielian AE , Gan W , Ge W , Gong F , Gu Z , Guan P , Heiman TJ , Higgins ME , Ji RR , Ke Z , Ketchum KA , Lai Z , Lei Y , Li Z , Li J , Liang Y , Lin X , Lu F , Merkulov GV , Milshina N , Moore HM , Naik AK , Narayan VA , Neelam B , Nusskern D , Rusch DB , Salzberg S , Shao W , Shue B , Sun J , Wang Z , Wang A , Wang X , Wang J , Wei M , Wides R , Xiao C , Yan C , Yao A , Ye J , Zhan M , Zhang W , Zhang H , Zhao Q , Zheng L , Zhong F , Zhong W , Zhu S , Zhao S , Gilbert D , Baumhueter S , Spier G , Carter C , Cravchik A , Woodage T , Ali F , An H , Awe A , Baldwin D , Baden H , Barnstead M , Barrow I , Beeson K , Busam D , Carver A , Center A , Cheng ML , Curry L , Danaher S , Davenport L , Desilets R , Dietz S , Dodson K , Doup L , Ferriera S , Garg N , Gluecksmann A , Hart B , Haynes J , Haynes C , Heiner C , Hladun S , Hostin D , Houck J , Howland T , Ibegwam C , Johnson J , Kalush F , Kline L , Koduru S , Love A , Mann F , May D , McCawley S , McIntosh T , McMullen I , Moy M , Moy L , Murphy B , Nelson K , Pfannkoch C , Pratts E , Puri V , Qureshi H , Reardon M , Rodriguez R , Rogers YH , Romblad D , Ruhfel B , Scott R , Sitter C , Smallwood M , Stewart E , Strong R , Suh E , Thomas R , Tint NN , Tse S , Vech C , Wang G , Wetter J , Williams S , Williams M , Windsor S , Winn-Deen E , Wolfe K , Zaveri J , Zaveri K , Abril JF , Guigo R , Campbell MJ , Sjolander KV , Karlak B , Kejariwal A , Mi H , Lazareva B , Hatton T , Narechania A , Diemer K , Muruganujan A , Guo N , Sato S , Bafna V , Istrail S , Lippert R , Schwartz R , Walenz B , Yooseph S , Allen D , Basu A , Baxendale J , Blick L , Caminha M , Carnes-Stine J , Caulk P , Chiang YH , Coyne M , Dahlke C , Mays A , Dombroski M , Donnelly M , Ely D , Esparham S , Fosler C , Gire H , Glanowski S , Glasser K , Glodek A , Gorokhov M , Graham K , Gropman B , Harris M , Heil J , Henderson S , Hoover J , Jennings D , Jordan C , Jordan J , Kasha J , Kagan L , Kraft C , Levitsky A , Lewis M , Liu X , Lopez J , Ma D , Majoros W , McDaniel J , Murphy S , Newman M , Nguyen T , Nguyen N , Nodell M , Pan S , Peck J , Peterson M , Rowe W , Sanders R , Scott J , Simpson M , Smith T , Sprague A , Stockwell T , Turner R , Venter E , Wang M , Wen M , Wu D , Wu M , Xia A , Zandieh A , Zhu X
Ref : Science , 291 :1304 , 2001
PubMedID: 11181995
Gene_locus related to this paper: human-AADAC , human-ABHD1 , human-ABHD10 , human-ABHD11 , human-ACHE , human-BCHE , human-LDAH , human-ABHD18 , human-CMBL , human-ABHD17A , human-KANSL3 , human-LIPA , human-LYPLAL1 , human-NDRG2 , human-NLGN3 , human-NLGN4X , human-NLGN4Y , human-PAFAH2 , human-PREPL , human-RBBP9 , human-SPG21

Title : Human liver arylacetamide deacetylase: Molecular cloning of a novel esterase involved in the metabolic activation of arylamine carcinogens with high sequence similarity to hormone sensitive lipase - Probst_1994_J.Biol.Chem_269_21650
Author(s) : Probst MR , Beer M , Beer D , Jenoe P , Meyer UA , Gasser R
Ref : Journal of Biological Chemistry , 34 :21650 , 1994
PubMedID: 8063807
Gene_locus related to this paper: human-AADAC

Title : Purification and characterization of a human liver arylacetamide deacetylase - Probst_1991_Biochem.Biophys.Res.Commun_177_453
Author(s) : Probst MR , Jeno P , Meyer UA
Ref : Biochemical & Biophysical Research Communications , 177 :453 , 1991
PubMedID: 2043131
Gene_locus related to this paper: human-AADAC