Beta-zearalenol

Zearalenol belongs to the family of Macrolides and Analogues. These are organic compounds containing a lactone ring of at least twelve members. The term 'macrolide' encompasses a diverse family of unrelated compounds with large macrolactam rings. Zearalenol derivative of zearalenone. The mycotoxin zearalenone has been contaminating maize and other grains. It can be hydrolyzed and inactivated by the lactonase ZHD. Zearalenone differs from other quorum-sensing lactones

General

Type : Mycotoxin-metabolite, Polyketide, Macrolide, Natural, Toxin

Chemical_Nomenclature : (2E,7S,11S)-7,15,17-trihydroxy-11-methyl-12-oxabicyclo[12.4.0]octadeca-1(18),2,14,16-tetraen-13-one

Canonical SMILES : CC1CCCC(CCCC=CC2=CC(=CC(=C2C(=O)O1)O)O)O

InChI : InChI=1S\/C18H24O5\/c1-12-6-5-9-14(19)8-4-2-3-7-13-10-15(20)11-16(21)17(13)18(22)23-12\/h3,7,10-12,14,19-21H,2,4-6,8-9H2,1H3\/b7-3+\/t12-,14-\/m0\/s1

InChIKey : FPQFYIAXQDXNOR-PMRAARRBSA-N

Other name(s) : CHEMBL372840  ||  CHEBI:35072  ||  Beta zearalenol  ||  beta-Zearalenol  ||  beta-ZOL


MW : 320.38

Formula : C18H24O5

CAS_number : 71030-11-0

PubChem : 6437352

UniChem : FPQFYIAXQDXNOR-PMRAARRBSA-N

Target

Structures : 5IE6, 5IE7, 6JR5, 6JRB, 6JRD

Families : Zearalenone-hydrolase

References (2)

Title : The Trp183 is essential in lactonohydrolase ZHD detoxifying zearalenone and zearalenols - Zhou_2020_Biochem.Biophys.Res.Commun_522_986
Author(s) : Zhou H , Li L , Zhan B , Wang S , Li J , Hu XJ
Ref : Biochemical & Biophysical Research Communications , 522 :986 , 2020
Abstract :
PubMedSearch : Zhou_2020_Biochem.Biophys.Res.Commun_522_986
PubMedID: 31810602
Gene_locus related to this paper: biooc-ZHD101

Title : Enhanced alpha-Zearalenol Hydrolyzing Activity of a Mycoestrogen-Detoxifying Lactonase by Structure-Based Engineering - Xu_2016_ACS.Catal_6_7657
Author(s) : Xu Z , Liu W , Chen CC , Li Q , Huang JW , Ko TP , Liu G , Peng W , Cheng YS , Chen Y , Jin J , Li H , Zheng Y , Guo RT
Ref : ACS Catal , 6 :7657 , 2016
Abstract :
PubMedSearch : Xu_2016_ACS.Catal_6_7657
PubMedID:
Gene_locus related to this paper: biooc-ZHD101