Zearalenol belongs to the family of Macrolides and Analogues. These are organic compounds containing a lactone ring of at least twelve members. The term 'macrolide' encompasses a diverse family of unrelated compounds with large macrolactam rings. Zearalenol derivative of zearalenone. The mycotoxin zearalenone has been contaminating maize and other grains. It can be hydrolyzed and inactivated by the lactonase ZHD. Zearalenone differs from other quorum-sensing lactones
Type : Mycotoxin-metabolite, Polyketide, Macrolide, Natural, Toxin
Chemical_Nomenclature : (2E,7S,11S)-7,15,17-trihydroxy-11-methyl-12-oxabicyclo[12.4.0]octadeca-1(18),2,14,16-tetraen-13-one
Canonical SMILES : CC1CCCC(CCCC=CC2=CC(=CC(=C2C(=O)O1)O)O)O
InChI : InChI=1S\/C18H24O5\/c1-12-6-5-9-14(19)8-4-2-3-7-13-10-15(20)11-16(21)17(13)18(22)23-12\/h3,7,10-12,14,19-21H,2,4-6,8-9H2,1H3\/b7-3+\/t12-,14-\/m0\/s1
InChIKey : FPQFYIAXQDXNOR-PMRAARRBSA-N
Other name(s) : CHEMBL372840 || CHEBI:35072 || Beta zearalenol || beta-Zearalenol || beta-ZOL
MW : 320.38
Formula : C18H24O5
CAS_number : 71030-11-0
PubChem : 6437352
UniChem : FPQFYIAXQDXNOR-PMRAARRBSA-N
Title : The Trp183 is essential in lactonohydrolase ZHD detoxifying zearalenone and zearalenols - Zhou_2020_Biochem.Biophys.Res.Commun_522_986 |
Author(s) : Zhou H , Li L , Zhan B , Wang S , Li J , Hu XJ |
Ref : Biochemical & Biophysical Research Communications , 522 :986 , 2020 |
Abstract : |
PubMedSearch : Zhou_2020_Biochem.Biophys.Res.Commun_522_986 |
PubMedID: 31810602 |
Gene_locus related to this paper: biooc-ZHD101 |
Title : Enhanced alpha-Zearalenol Hydrolyzing Activity of a Mycoestrogen-Detoxifying Lactonase by Structure-Based Engineering - Xu_2016_ACS.Catal_6_7657 |
Author(s) : Xu Z , Liu W , Chen CC , Li Q , Huang JW , Ko TP , Liu G , Peng W , Cheng YS , Chen Y , Jin J , Li H , Zheng Y , Guo RT |
Ref : ACS Catal , 6 :7657 , 2016 |
Abstract : |
PubMedSearch : Xu_2016_ACS.Catal_6_7657 |
PubMedID: |
Gene_locus related to this paper: biooc-ZHD101 |