DHDMP
Substrate of peroxisomal acyl-coenzyme A (CoA) hydrolase MpaH. Intermediate in the biosynthetic pathway of Mycophenolic acid (MPA) from filamentous fungi is the first natural product antibiotic
General
Type : Natural, Benzofuran
Chemical_Nomenclature : (4R)-7-hydroxy-4,6-dimethyl-4-[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trienyl]-3H-2-benzofuran-1,5-dione
Canonical SMILES : CC1=C(C2=C(COC2=O)C(C1=O)(C)CC=C(C)CCC=C(C)CCC=C(C)C)O
InChI : InChI=1S\/C25H34O4\/c1-16(2)9-7-10-17(3)11-8-12-18(4)13-14-25(6)20-15-29-24(28)21(20)22(26)19(5)23(25)27\/h9,11,13,26H,7-8,10,12,14-15H2,1-6H3\/b17-11+,18-13+\/t25-\/m1\/s1
InChIKey : YRKOMSPAXUNNRG-CYIFYSEMSA-N
Other name(s) : Farnesyl-5,7-dihydroxy-4,6-dimethylphthalide
Target
Structures : No structure
Families : MpaH
References (2)
| Title : Compartmentalized biosynthesis of mycophenolic acid - Zhang_2019_Proc.Natl.Acad.Sci.U.S.A_116_13305 |
| Author(s) : Zhang W , Du L , Qu Z , Zhang X , Li F , Li Z , Qi F , Wang X , Jiang Y , Men P , Sun J , Cao S , Geng C , Wan X , Liu C , Li S |
| Ref : Proc Natl Acad Sci U S A , 116 :13305 , 2019 |
| Abstract : |
| PubMedSearch : Zhang_2019_Proc.Natl.Acad.Sci.U.S.A_116_13305 |
| PubMedID: 31209052 |
| Gene_locus related to this paper: penbr-mpaH , penbr-mpac |
| Title : Complete biosynthetic pathway of anditomin: nature's sophisticated synthetic route to a complex fungal meroterpenoid - Matsuda_2014_J.Am.Chem.Soc_136_15326 |
| Author(s) : Matsuda Y , Wakimoto T , Mori T , Awakawa T , Abe I |
| Ref : Journal of the American Chemical Society , 136 :15326 , 2014 |
| Abstract : |
| PubMedSearch : Matsuda_2014_J.Am.Chem.Soc_136_15326 |
| PubMedID: 25216349 |
| Gene_locus related to this paper: emeva-andm |