penbr-mpaH
Penicillium brevicompactum Mycophenolic acid synthesis protein H (peroxisomal acyl-coenzyme A (CoA) hydrolase) mpaH
Comment
Hydrolase\; part of the gene cluster that mediates the biosynthesis of mycophenolic acid (MPA), the first isolated antibiotic natural product in the world. Farnesyl-5,7-dihydroxy-4,6-dimethylphthalide(DHDMP) substrate of mpaH for transformation into demethylmycophenolic acid (DMMPA) (sequence of F1DBB4 some difference.Here the sequence from structure
Relationship
Family : MpaH
Block : X
Position in NCBI Life Tree : Penicillium brevicompactum
(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)
> cellular organisms N E > Eukaryota N E > Opisthokonta N E > Fungi N E > Dikarya N E > Ascomycota N E > saccharomyceta N E > Pezizomycotina N E > leotiomyceta N E > Eurotiomycetes N E > Eurotiomycetidae N E > Eurotiales N E > Aspergillaceae N E > Penicillium N E > Penicillium brevicompactum N EMolecular evidence
Sequence
Peptide
MSTEKFTITE HLVPGSHIRE YPGSTVNQED VLKIHVKQYT PKREGPVPDD AITFIATHGV GLPKELYEPL WDELLDQASG FHIRAIWMAD VASMNQSGIH NEDKLSMDCS WMDHARDLLL MINHFRDQMP RPLVGIGHSF GGNIITNLAY LHPRLFTTLL LLDPLIQLSP PSLGFGTDAP SAINYTLWRD DVWPSREVAI RANRAIMQGM DPRCLDRMTK HFFRDLPTPL YPDVEAIKAL FGTTADSTTT PVTLTTPKYH ELVAQIRQNF NARDPKTGRI EVPRDTHADM DPLVAYIPLY RPEPRSTFRR LETLRPSCLW VIAGATFLNI DEIREGVKIC GSGIGGSGGV PDGRVREVVL PGFGHLMPFQ EVKTVAETCI VWLQQEMDRF RQTERQWKED RDGKSHLAVE ENWYKVLKPI PSGRKKRNDK GKL
References (3)
| Title : Structural basis for substrate specificity of the peroxisomal acyl-CoA hydrolase MpaH' involved in mycophenolic acid biosynthesis - You_2021_FEBS.J_288_5768 |
| Author(s) : You C , Li F , Zhang X , Ma L , Zhang YZ , Zhang W , Li S |
| Ref : Febs J , 288 :5768 , 2021 |
| Abstract : |
| PubMedSearch : You_2021_FEBS.J_288_5768 |
| PubMedID: 33843134 |
| Gene_locus related to this paper: penbr-mpaH |
| Title : Compartmentalized biosynthesis of mycophenolic acid - Zhang_2019_Proc.Natl.Acad.Sci.U.S.A_116_13305 |
| Author(s) : Zhang W , Du L , Qu Z , Zhang X , Li F , Li Z , Qi F , Wang X , Jiang Y , Men P , Sun J , Cao S , Geng C , Wan X , Liu C , Li S |
| Ref : Proc Natl Acad Sci U S A , 116 :13305 , 2019 |
| Abstract : |
| PubMedSearch : Zhang_2019_Proc.Natl.Acad.Sci.U.S.A_116_13305 |
| PubMedID: 31209052 |
| Gene_locus related to this paper: penbr-mpaH , penbr-mpac |
| Title : Functional characterization of MpaG', the O-methyltransferase involved in the biosynthesis of mycophenolic acid - Zhang_2015_Chembiochem_16_565 |
| Author(s) : Zhang W , Cao S , Qiu L , Qi F , Li Z , Yang Y , Huang S , Bai F , Liu C , Wan X , Li S |
| Ref : Chembiochem , 16 :565 , 2015 |
| Abstract : |
| PubMedSearch : Zhang_2015_Chembiochem_16_565 |
| PubMedID: 25630520 |
| Gene_locus related to this paper: penbr-mpaH , penbr-mpac |