MpaH
Comment
Penicillium brevicompactum MpaH Hydrolase; part of the gene cluster that mediates the biosynthesis of mycophenolic acid (MPA), the first isolated antibiotic natural product in the world. Farnesyl-5,7-dihydroxy-4,6-dimethylphthalide(DHDMP) substrate of mpaH for transformation into demethylmycophenolic acid (DMMPA). The family is extracted from 6_AlphaBeta_hydrolase.
Database
Interpro : No interpro
PIRSF : No PIRSF
Pdoc : No Pdoc
Pfam : No Pfam
Prints : No Print
EC Number : No EC Number
Sequences
| Peptide in | Fasta |
| Nucleotide in | Fasta |
| Alignment with Multalin | Text only |
| Seed alignment with MAFFT | No colour / coloured with Mview |
| Alignment with MAFFT | No colour / coloured with Mview |
| Dendrogram | The dnd file |
| Structure | Name | Proteins |
|---|---|---|
| 7DBI | Crystal structure of the peroxisomal acyl-CoA hydrolase MpaH | penbr-mpaH |
| 7DBL | Acyl-CoA hydrolase MpaH mutant S139A in complex with MPA Mycophenolic-acid | penbr-mpaH |
| Gene_locus | Name | Species |
|---|---|---|
| 9euro-a0a017s6r6 | Aspergillus ruber CBS 135680. Putative toxin biosynthesis protein | Aspergillus ruber CBS 135680 |
| 9euro-a0a072p6g5 | Exophiala aquamarina CBS 119918. AB hydrolase-1 domain-containing protein | Exophiala aquamarina CBS 119918 |
| 9euro-a0a072p908 | Exophiala aquamarina CBS 119918. AB hydrolase-1 domain-containing protein | Exophiala aquamarina CBS 119918 |
| 9euro-a0a0d1vyt5 | Exophiala sideris. AB hydrolase-1 domain-containing protein | Exophiala sideris |
| 9euro-a0a0d1ww20 | Exophiala sideris. AB hydrolase-1 domain-containing protein | Exophiala sideris |
| 9euro-a0a0d2b2t5 | Exophiala oligosperma. AB hydrolase-1 domain-containing protein | Exophiala oligosperma |
| 9euro-a0a0d2bij7 | Exophiala spinifera. AB hydrolase-1 domain-containing protein | Exophiala spinifera |
| 9euro-a0a0d2bk11 | Exophiala xenobiotica. AB hydrolase-1 domain-containing protein | Exophiala xenobiotica |
| 9euro-a0a0d2bkr2 | Exophiala spinifera. AB hydrolase-1 domain-containing protein | Exophiala spinifera |
| 9euro-a0a0d2ckv6 | Cladophialophora immunda. AB hydrolase-1 domain-containing protein | Cladophialophora immunda |
| 9euro-a0a0d2cl05 | Exophiala xenobiotica. AB hydrolase-1 domain-containing protein | Exophiala xenobiotica |
| 9euro-a0a0d2czk8 | Cladophialophora immunda. AB hydrolase-1 domain-containing protein | Cladophialophora immunda |
| 9euro-a0a0d2dzq3 | Phialophora americana. AB hydrolase-1 domain-containing protein | Phialophora americana |
| 9euro-a0a0d2gxq5 | Fonsecaea pedrosoi CBS 271.37. Unplaced genomic scaffold supercont1.1, whole genome shotgun sequence | Fonsecaea pedrosoi CBS 271.37 |
| 9euro-a0a0d2j6i0 | Rhinocladiella mackenziei CBS 650.93. Rhinocladiella mackenziei CBS 650.93 unplaced genomic scaffold supercont1.4, whole genome shotgun sequence | Rhinocladiella mackenziei CBS 650.93 |
| 9euro-a0a0d2jmg6 | Fonsecaea multimorphosa CBS 102226. AB hydrolase-1 domain-containing protein | Fonsecaea multimorphosa CBS 102226 |
| 9euro-a0a0f8wsg7 | Aspergillus rambellii. AB hydrolase-1 domain-containing protein | Aspergillus rambellii |
| 9euro-a0a0g2egh8 | Phaeomoniella chlamydospora. Putative toxin biosynthesis | Phaeomoniella chlamydospora |
| 9euro-a0a0h1bel0 | Blastomyces silverae. AB hydrolase-1 domain-containing protein | Blastomyces silverae |
| 9euro-a0a0k8l5t8 | Aspergillus udagawae. Peroxisomal membrane protein LPX1 | Aspergillus udagawae |
| 9euro-a0a0m8pdu5 | Penicillium nordicum. AB hydrolase-1 domain-containing protein | Penicillium nordicum |
| 9euro-a0a0u5cm99 | Aspergillus calidoustus. Putative Toxin biosynthesis protein | Aspergillus calidoustus |
| 9euro-a0a101mch4 | Penicillium freii\; Penicillium polonicum. AB hydrolase-1 domain-containing protein | Penicillium freii |
| 9euro-a0a178zmk2 | Fonsecaea erecta. AB hydrolase-1 domain-containing protein | Fonsecaea erecta |
| 9euro-a0a1b7p8j2 | Emmonsia sp. CAC-2015a. AB hydrolase-1 domain-containing protein | Emmonsia sp. CAC-2015a |
| 9euro-a0a1c1cu93 | Cladophialophora carrionii. Toxin biosynthesis protein | Cladophialophora carrionii |
| 9euro-a0a1e3bp23 | Aspergillus cristatus. AB hydrolase-1 domain-containing protein | Aspergillus cristatus |
| 9euro-a0a1f7zmz7 | Aspergillus bombycis. AB hydrolase-1 domain-containing protein | Aspergillus bombycis |
| 9euro-a0a1f7zzn8 | Aspergillus bombycis. Toxin biosynthesis protein | Aspergillus bombycis |
| 9euro-a0a1j9plr9 | Emergomyces pasteurianus Ep9510. AB hydrolase-1 domain-containing protein | Emergomyces pasteurianus Ep9510 |
| 9euro-a0a1j9prh8 | Blastomyces percursus. AB hydrolase-1 domain-containing protein | Blastomyces percursus |
| 9euro-a0a1l9tdh3 | Aspergillus sydowii CBS 593.65. AB hydrolase-1 domain-containing protein | Aspergillus sydowii CBS 593.65 |
| 9euro-a0a1q5uk24 | Penicillium subrubescens. AB hydrolase-1 domain-containing protein | Penicillium subrubescens |
| 9euro-a0a1v6q4p2 | Penicillium antarcticum. AB hydrolase-1 domain-containing protein | Penicillium antarcticum |
| 9euro-a0a1v6qfp3 | Penicillium antarcticum. AB hydrolase-1 domain-containing protein | Penicillium antarcticum |
| 9euro-a0a1v6r0e0 | Penicillium solitum. AB hydrolase-1 domain-containing protein | Penicillium solitum |
| 9euro-a0a1v6td81 | Penicillium steckii. AB hydrolase-1 domain-containing protein | Penicillium steckii |
| 9euro-a0a1v6tn69 | Penicillium steckii. AB hydrolase-1 domain-containing protein | Penicillium steckii |
| 9euro-a0a232m127 | Elaphomyces granulatus. AB hydrolase-1 domain-containing protein | Elaphomyces granulatus |
| 9euro-a0a2b7wzy9 | Blastomyces parvus. AB hydrolase-1 domain-containing protein | Blastomyces parvus |
| 9euro-a0a2b7xtu8 | Polytolypa hystricis UAMH7299. AB hydrolase-1 domain-containing protein | Polytolypa hystricis UAMH7299 |
| 9euro-a0a2b7xu13 | Helicocarpus griseus UAMH5409. AB hydrolase-1 domain-containing protein | Helicocarpus griseus UAMH5409 |
| 9euro-a0a2b7z8d4 | Emmonsia crescens. AB hydrolase-1 domain-containing protein | Emmonsia crescens |
| 9euro-a0a2g7fy60 | Aspergillus arachidicola\; Aspergillus parasiticus\; Aspergillus novoparasiticu. Toxin biosynthesis protein | Aspergillus arachidicola |
| 9euro-a0a2i2fpe7 | Aspergillus candidus. Toxin biosynthesis protein | Aspergillus candidus |
| 9euro-a0a2i2g1i9 | Aspergillus steynii IBT 23096. Putative toxin biosynthesis protein | Aspergillus steynii IBT 23096 |
| 9euro-a0a2i2g626 | Aspergillus steynii IBT 23096. Putative hydrolase | Aspergillus steynii IBT 23096 |
| 9euro-a0a2i2ger9 | Aspergillus steynii IBT 23096. Putative toxin biosynthesis protein | Aspergillus steynii IBT 23096 |
| 9euro-a0a2i2gqd5 | Aspergillus steynii IBT 23096. Alpha\/beta-hydrolase | Aspergillus steynii IBT 23096 |
| 9euro-a0a317uwf2 | Aspergillus heteromorphus CBS 117.55. AB hydrolase-1 domain-containing protein | Aspergillus heteromorphus CBS 117.55 |
| 9euro-a0a317wnh1 | Aspergillus heteromorphus CBS 117.55. AB hydrolase-1 domain-containing protein | Aspergillus heteromorphus CBS 117.55 |
| 9euro-a0a317x900 | Aspergillus sclerotioniger CBS 115572. Toxin biosynthesis protein | Aspergillus sclerotioniger CBS 115572 |
| 9euro-a0a317xbx9 | Aspergillus sclerotioniger CBS 115572. Alpha\/beta-hydrolase | Aspergillus sclerotioniger CBS 115572 |
| 9euro-a0a319d4z4 | Aspergillus ellipticus CBS 707.79. Host-specific AK-toxin Akt2 | Aspergillus ellipticus CBS 707.79 |
| 9euro-a0a319dbf1 | Aspergillus ellipticus CBS 707.79. AB hydrolase-1 domain-containing protein | Aspergillus ellipticus CBS 707.79 |
| 9euro-a0a319dk02 | Aspergillus ellipticus CBS 707.79. AB hydrolase-1 domain-containing protein | Aspergillus ellipticus CBS 707.79 |
| 9euro-a0a319dna0 | Aspergillus ellipticus CBS 707.79. Toxin biosynthesis protein | Aspergillus ellipticus CBS 707.79 |
| 9euro-a0a364lde5 | Talaromyces amestolkiae. AB hydrolase-1 domain-containing protein | Talaromyces amestolkiae |
| 9euro-a0a395gpl4 | Aspergillus ibericus CBS 121593. Alpha\/beta-hydrolase | Aspergillus ibericus CBS 121593 |
| 9euro-a0a395gvf0 | Aspergillus ibericus CBS 121593. Toxin biosynthesis protein-like protein | Aspergillus ibericus CBS 121593 |
| 9euro-a0a395gzj5 | Aspergillus ibericus CBS 121593. Toxin biosynthesis protein | Aspergillus ibericus CBS 121593 |
| 9euro-a0a3a2zq35 | Aspergillus sclerotialis. Toxin biosynthesis protein | Aspergillus sclerotialis |
| 9euro-a0a4s3j441 | Aspergillus tanneri. AB hydrolase-1 domain-containing protein | Aspergillus tanneri |
| 9euro-a0a5n5wiu2 | Aspergillus leporis. Alpha\/Beta hydrolase protein | Aspergillus leporis |
| 9euro-a0a5n6emp3 | Aspergillus novoparasiticus. AB hydrolase-1 domain-containing protein | Aspergillus novoparasiticus |
| 9euro-a0a5n6u0l8 | Aspergillus avenaceus. Toxin biosynthesis protein | Aspergillus avenaceus |
| 9euro-a0a5n6usq8 | Aspergillus tamarii. Alpha\/Beta hydrolase protein | Aspergillus tamarii |
| 9euro-a0a5n6z7p7 | Aspergillus coremiiformis. Alpha\/beta hydrolase family-domain-containing protein | Aspergillus coremiiformis |
| 9euro-a0a5n6zw35 | Aspergillus caelatus. Alpha\/Beta hydrolase protein | Aspergillus caelatus |
| 9euro-a0a5n7b7k9 | Aspergillus bertholletius. Alpha\/Beta hydrolase protein | Aspergillus bertholletius |
| 9euro-a0a5n7d2z0 | Aspergillus pseudonomius. Alpha\/Beta hydrolase protein | Aspergillus pseudonomius |
| 9euro-w9wkp8 | Cladophialophora yegresii CBS 114405. AB hydrolase-1 domain-containing protein | Cladophialophora yegresii CBS 114405 |
| 9euro-w9x469 | Cladophialophora psammophila CBS 110553. AB hydrolase-1 domain-containing protein | Cladophialophora psammophila CBS 110553 |
| 9euro-w9y5x4 | Capronia epimyces CBS 606.96. AB hydrolase-1 domain-containing protein | Capronia epimyces CBS 606.96 |
| 9euro-w9y9n2 | Capronia coronata CBS 617.96. AB hydrolase-1 domain-containing protein | Capronia coronata CBS 617.96 |
| 9helo-a0a194xka3 | Phialocephala scopiformis. Alpha\/beta-hydrolase | Phialocephala scopiformis |
| 9helo-a0a1e1jvp0 | Rhynchosporium commune. Related to host-specific AK-toxin Akt2 | Rhynchosporium commune |
| 9helo-a0a2v1cbn2 | Cadophora sp. DSE1049. AB hydrolase-1 domain-containing protein | Cadophora sp. DSE1049 |
| 9helo-a0a370u2s4 | Venustampulla echinocandica. AB hydrolase-1 domain-containing protein | Venustampulla echinocandica |
| 9hypo-a0a0f7zy10 | Hirsutella minnesotensis 3608. AB hydrolase-1 domain-containing protein | Hirsutella minnesotensis 3608 |
| 9hypo-a0a2a9pdz6 | Ophiocordyceps unilateralis. AB hydrolase-1 domain-containing protein | Ophiocordyceps unilateralis |
| 9hypo-a0a369gi77 | Ophiocordyceps sp. 'camponoti-leonardi'. AB hydrolase-1 domain-containing protein | Ophiocordyceps sp. 'camponoti-leonardi' |
| 9hypo-a0a369hde7 | Ophiocordyceps sp. 'camponoti-saundersi'. AB hydrolase-1 domain-containing protein | Ophiocordyceps sp. 'camponoti-saundersi' |
| 9pezi-a0a093xfs5 | Pseudogymnoascus sp.. AB hydrolase-1 domain-containing protein | Pseudogymnoascus sp. VKM F-3557 |
| 9pezi-a0a094bm62 | Pseudogymnoascus sp. VKM F-4513 (FW-928). AB hydrolase-1 domain-containing protein | Pseudogymnoascus sp. VKM F-4513 (FW-928) |
| 9pezi-a0a094deg8 | Pseudogymnoascus sp. VKM F-4515 (FW-2607). AB hydrolase-1 domain-containing protein | Pseudogymnoascus sp. VKM F-4515 (FW-2607) |
| 9pezi-a0a094hb62 | Pseudogymnoascus sp. VKM F-4519 (FW-2642). AB hydrolase-1 domain-containing protein | Pseudogymnoascus sp. VKM F-4519 (FW-2642) |
| 9pezi-a0a094i599 | Pseudogymnoascus sp. AB hydrolase-1 domain-containing protein | Pseudogymnoascus sp. VKM F-4520 (FW-2644) |
| 9pezi-a0a0c3csx4 | Oidiodendron maius Zn. AB hydrolase-1 domain-containing protein | Oidiodendron maius Zn |
| 9pezi-a0a0d2aie8 | Verruconis gallopava. AB hydrolase-1 domain-containing protein | Verruconis gallopava |
| 9pezi-a0a0g2fkn7 | Diaporthe ampelina. Putative toxin biosynthesis protein | Diaporthe ampelina |
| 9pezi-a0a139gy99 | Pseudocercospora eumusae. AB hydrolase-1 domain-containing protein | Pseudocercospora eumusae |
| 9pezi-a0a139i8i6 | Pseudocercospora musae. AB hydrolase-1 domain-containing protein | Pseudocercospora musae |
| 9pezi-a0a194umu7 | Valsa mali var. pyri. Peroxisomal membrane protein LPX1 | Valsa mali var. pyri |
| 9pezi-a0a1b8c046 | Pseudogymnoascus sp. WSF 3629. AB hydrolase-1 domain-containing protein | Pseudogymnoascus sp. WSF 3629 |
| 9pezi-a0a1b8elz6 | Pseudogymnoascus sp. 05NY08. AB hydrolase-1 domain-containing protein | Pseudogymnoascus sp. 05NY08 |
| 9pezi-a0a1j9sdn6 | Diplodia corticola. Toxin biosynthesis protein | Diplodia corticola |
| 9pezi-a0a1s8blf0 | Diplodia seriata. Peroxisomal membrane protein LPX1 | Diplodia seriata |
| 9pezi-a0a1v8v2r2 | Rachicladosporium sp. CCFEE 5018. AB hydrolase-1 domain-containing protein | Rachicladosporium sp. CCFEE 5018 |
| 9pezi-a0a1y2wzb7 | Daldinia sp. EC12. AB hydrolase-1 domain-containing protein | Daldinia sp. EC12 |
| 9pezi-a0a2d3va52 | Ramularia collo-cygni. Related to host-specific AK-toxin Akt2 | Ramularia collo-cygni |
| 9pezi-a0a2k1qy12 | Sphaceloma murrayae. Peroxisomal membrane protein LPX1 | Sphaceloma murrayae |
| 9pezi-a0a2p2sws4 | Pseudogymnoascus verrucosus\; Pseudogymnoascus sp. AB hydrolase-1 domain-containing protein | Pseudogymnoascus verrucosus |
| 9pezi-a0a2p5i745 | Diaporthe helianthi. Toxin biosynthesis protein | Diaporthe helianthi |
| 9pezi-a0a423vc34 | Valsa sordida. AB hydrolase-1 domain-containing protein | Valsa sordida |
| 9pezi-a0a423vzy9 | Cytospora leucostoma. AB hydrolase-1 domain-containing protein | Cytospora leucostoma |
| 9pezi-a0a423wy34 | Valsa malicola. AB hydrolase-1 domain-containing protein | Valsa malicola |
| 9pezi-a0a4q4sud3 | Monosporascus ibericus\; Monosporascus sp. AB hydrolase-1 domain-containing protein | Monosporascus ibericus |
| 9pezi-a0a4u0u1x5 | Hortaea thailandica. AB hydrolase-1 domain-containing protein | Hortaea thailandica |
| 9pezi-a0a4u0uw20 | Friedmanniomyces endolithicus. AB hydrolase-1 domain-containing protein | Friedmanniomyces endolithicus |
| 9pezi-a0a4u0uz49 | Friedmanniomyces endolithicus. AB hydrolase-1 domain-containing protein | Friedmanniomyces endolithicus |
| 9pezi-a0a4u0x1b5 | Cryomyces minteri. AB hydrolase-1 domain-containing protein | Cryomyces minteri |
| 9pezi-a0a4u0xpm5 | Friedmanniomyces simplex. AB hydrolase-1 domain-containing protein | Friedmanniomyces simplex |
| 9pezi-a0a4v5nhk2 | Friedmanniomyces simplex. AB hydrolase-1 domain-containing protein | Friedmanniomyces simplex |
| 9pezi-a0a507au16 | Phialemoniopsis curvata. AB hydrolase-1 domain-containing protein | Phialemoniopsis curvata |
| 9pezi-a0a553i2c5 | Xylaria flabelliformis. AB hydrolase-1 domain-containing protein | Xylaria flabelliformis |
| 9pezi-a0a5n5di12 | Lasiodiplodia theobromae. Abhydrolase domain-containing protein mpaH | Lasiodiplodia theobromae |
| 9pleo-a0a178ame1 | Stagonospora sp. SRC1lsM3a. Alpha\/beta-hydrolase | Stagonospora sp. SRC1lsM3a |
| 9pleo-a0a178e538 | Pyrenochaeta sp. DS3sAY3a. Alpha\/beta-hydrolase | Pyrenochaeta sp. DS3sAY3a |
| 9pleo-a0a1y1zzb2 | Clohesyomyces aquaticus. Alpha\/beta hydrolase family-domain-containing protein | Clohesyomyces aquaticus |
| 9pleo-a0a2v1ee64 | Periconia macrospinosa. AB hydrolase-1 domain-containing protein | Periconia macrospinosa |
| 9pleo-a0a364mxp4 | Stemphylium lycopersici. Toxin biosynthesis protein | Stemphylium lycopersici |
| 9pleo-a0a3m7m3e7 | Pyrenophora seminiperda CCB06. Toxin biosynthesis | Pyrenophora seminiperda CCB06 |
| ajecg-c0nmt9 | Ajellomyces capsulatus (Darling's disease fungus) (Histoplasma capsulatum). AB hydrolase-1 domain-containing protein | Ajellomyces capsulatus |
| altal-a0a177drs1 | Alternaria alternata (Alternaria rot fungus) (Torula alternata). Alpha\/beta-hydrolase | Alternaria alternata |
| altal-actt2 | Alternaria alternata (Alternaria rot fungus) (Torula alternata). ACT-toxin biosynthesis protein 2 | Alternaria alternata |
| amore-a0a2t3ay04 | Amorphotheca resinae ATCC 22711. AB hydrolase-1 domain-containing protein | Amorphotheca resinae ATCC 22711 |
| aspaw-a0a401kcz4 | Aspergillus awamori (Black koji mold)\; Aspergillus welwitschiae\; Aspergillus niger. Peroxisomal membrane protein LPX1 | Aspergillus awamori |
| aspaw-a0a401kpx5 | Aspergillus awamori (Black koji mold)\; Aspergillus welwitschiae\; Aspergillus niger . Peroxisomal membrane protein LPX1 | Aspergillus awamori |
| aspaw-a0a401l4n0 | Aspergillus awamori (Black koji mold). Peroxisomal membrane protein LPX1 | Aspergillus awamori |
| aspbc-a0a1l9u2l4 | Aspergillus brasiliensis (strain CBS 101740 \/ IMI 381727 \/ IBT 21946). AB hydrolase-1 domain-containing protein | Aspergillus brasiliensis |
| aspbc-a0a1l9u6h4 | Aspergillus brasiliensis (strain CBS 101740 \/ IMI 381727 \/ IBT 21946). AB hydrolase-1 domain-containing protein | Aspergillus brasiliensis |
| aspc5-a0a1r3rmn9 | Aspergillus carbonarius (strain ITEM 5010). AB hydrolase-1 domain-containing protein | Aspergillus carbonarius |
| aspcl-a1cif4 | Aspergillus clavatus toxin biosynthesis protein, putative | Aspergillus clavatus |
| aspgl-a0a1l9ve90 | Aspergillus glaucus CBS 516.65. AB hydrolase-1 domain-containing protein | Aspergillus glaucus CBS 516.65 |
| asphc-a0a395i3h1 | Aspergillus homomorphus (strain CBS 101889). AB hydrolase-1 domain-containing protein | Aspergillus homomorphus |
| aspkw-g7xq95 | Aspergillus kawachii (White koji mold) (Aspergillus awamori var. kawachi)\; Aspergillus tubingensis\; Aspergillus niger. Similar to toxin biosynthesis protein | Aspergillus kawachii |
| aspkw-g7xzf8 | Aspergillus kawachii (strain NBRC 4308) (White koji mold) (Aspergillus awamori var. kawachi). Toxin biosynthesis protein | Aspergillus kawachii |
| aspnc-a2qw57 | Aspergillus niger\; Aspergillus awamori (Black koji mold)\; Aspergillus welwitschiae. Aspergillus niger contig An11c0150, genomic contig | Aspergillus niger |
| aspng-a0a100iew6 | Aspergillus niger. Toxin biosynthesis protein | Aspergillus niger |
| aspno-a0a0l1isw6 | Aspergillus nomiae NRRL 13137. AB hydrolase-1 domain-containing protein | Aspergillus nomiae NRRL 13137 |
| aspno-a0a0l1j4h1 | Aspergillus nomiae NRRL 13137. Toxin biosynthesis protein | Aspergillus nomiae NRRL 13137 |
| aspor-q2u822 | Aspergillus oryzae predicted protein | Aspergillus oryzae |
| aspoz-a0a1s9d9g3 | Aspergillus oryzae (Yellow koji mold)\; Aspergillus parasiticus\; Aspergillus arachidicola\; Aspergillus novoparasiticus\; Aspergillus flavus. AB hydrolase-1 domain-containing protein | Aspergillus oryzae |
| asppa-a0a5n6d5y2 | Aspergillus parasiticus. Alpha\/beta-hydrolase | Aspergillus parasiticus |
| aspps-a0a5n6sls1 | Aspergillus pseudotamarii\; Aspergillus tamarii. Toxin biosynthesis protein | Aspergillus pseudotamarii |
| aspps-a0a5n6t244 | Aspergillus pseudotamarii. Alpha\/Beta hydrolase protein | Aspergillus pseudotamarii |
| aspsb-a0a319dz77 | Aspergillus sclerotiicarbonarius (strain CBS 121057 \/ IBT 28362). AB hydrolase-1 domain-containing protein | Aspergillus sclerotiicarbonarius |
| aspsb-a0a319enl3 | Aspergillus sclerotiicarbonarius (strain CBS 121057 \/ IBT 28362). Alpha\/beta-hydrolase | Aspergillus sclerotiicarbonarius |
| aspsb-a0a319eq64 | Aspergillus sclerotiicarbonarius (strain CBS 121057 \/ IBT 28362). AB hydrolase-1 domain-containing protein | Aspergillus sclerotiicarbonarius |
| aspsb-a0a319ewh7 | Aspergillus sclerotiicarbonarius (strain CBS 121057 \/ IBT 28362). Toxin biosynthesis protein | Aspergillus sclerotiicarbonarius |
| asptc-a0a1l9mx83 | Aspergillus tubingensis (strain CBS 134.48). AB hydrolase-1 domain-containing protein | Aspergillus tubingensis |
| asptc-a0a1l9nby7 | Aspergillus tubingensis\; Aspergillus kawachii (White koji mold) (Aspergillus awamori\; Aspergillus niger. AB hydrolase-1 domain-containing protein | Aspergillus tubingensis |
| asptn-q0ct68 | Aspergillus terreus (strain NIH 2624 \/ FGSC A1156). AB hydrolase-1 domain-containing protein | Aspergillus terreus |
| aspve-a0a1l9pvz9 | Aspergillus versicolor CBS 583.65. AB hydrolase-1 domain-containing protein | Aspergillus versicolor CBS 583.65 |
| aspwe-a0a1l9rlq2 | Aspergillus wentii DTO 134E9. AB hydrolase-1 domain-containing protein | Aspergillus wentii DTO 134E9 |
| aurpu-a0a074y000 | Aureobasidium pullulans EXF-150. Toxin biosynthesis protein-like protein | Aureobasidium pullulans EXF-150 |
| aurse-a0a074yt75 | Aureobasidium subglaciale (strain EXF-2481) (Aureobasidium pullulans var. subglaciale). AB hydrolase-1 domain-containing protein | Aureobasidium subglaciale |
| baupa-m2nq79 | Baudoinia panamericana (strain UAMH 10762) (Angels' share fungus) (Baudoinia compniacensis (strain UAMH 10762)). AB hydrolase-1 domain-containing protein | Baudoinia panamericana |
| blags-a0a179udh1 | Blastomyces gilchristii (Blastomyces dermatitidis)\; Ajellomyces dermatitidis. Toxin biosynthesis protein | Blastomyces gilchristii |
| botf1-m7tg61 | Botryotinia fuckeliana (strain BcDW1) (Noble rot fungus) (Botrytis cinerea). Putative toxin biosynthesis protein | Botryotinia fuckeliana |
| byssn-v5gek1 | Byssochlamys spectabilis (strain No. 5 \/ NBRC 109023) (Paecilomyces variotii). Toxin biosynthesis protein, putative | Byssochlamys spectabilis |
| byssp-a0a443i5x3 | Byssochlamys spectabilis (Paecilomyces variotii). Putative toxin biosynthesis protein | Byssochlamys spectabilis |
| cocca-w6y1v2 | Bipolaris zeicola\; Cochliobolus sativus(Common root rot and spot blotch fungus) (Bipolaris sorokiniana). AB hydrolase-1 domain-containing protein | Bipolaris zeicola 26-R-13 |
| coch5-m2uul8 | Cochliobolus heterostrophus (strain C5 \/ ATCC 48332 \/ race O) (Southern corn leaf blight fungus) (Bipolaris maydis). AB hydrolase-1 domain-containing protein | Cochliobolus heterostrophus |
| cona1-r7yhf6 | Coniosporium apollinis (strain CBS 100218) (Rock-inhabiting black yeast). AB hydrolase-1 domain-containing protein | Coniosporium apollinis |
| corcc-a0a2t2p617 | Corynespora cassiicola Philippines. Alpha\/beta-hydrolase | Corynespora cassiicola Philippines |
| didra-a0a163cx35 | Didymella rabiei (Chickpea ascochyta blight fungus) (Mycosphaerella rabiei). AB hydrolase-1 domain-containing protein | Didymella rabiei |
| dotsn-n1q415 | Dothistroma septosporum (strain NZE10 \/ CBS 128990) (Red band needle blight fungus) (Mycosphaerella pini). AB hydrolase-1 domain-containing protein | Dothistroma septosporum |
| emeni-q5auk5 | Emericella nidulans (Aspergillus nidulans) hypothetical protein | Aspergillus nidulans FGSC A4 |
| emeni-q5b719 | Emericella nidulans (strain FGSC A4 \/ ATCC 38163 \/ CBS 112.46 \/ NRRL 194 \/ M139) (Aspergillus nidulans). Toxin biosynthesis protein, putative (AFU_orthologue AFUA_4G12320) | Emericella nidulans |
| eping-a0a1y2lpa3 | Epicoccum nigrum (Soil fungus) (Epicoccum purpurascens). AB hydrolase-1 domain-containing protein | Epicoccum nigrum |
| eutla-m7t4a9 | Eutypa lata (strain UCR-EL1) (Grapevine dieback disease fungus) (Eutypa armeniacae). Putative toxin biosynthesis protein | Eutypa lata |
| exodn-h6btr2 | Exophiala dermatitidis (strain ATCC 34100 \/ CBS 525.76 \/ NIH\/UT8656) (Black yeast) (Wangiella dermatitidis). AB hydrolase-1 domain-containing protein | Exophiala dermatitidis |
| exome-a0a0d1xkv7 | Exophiala mesophila (Black yeast). AB hydrolase-1 domain-containing protein | Exophiala mesophila |
| gaet3-j3p061 | Gaeumannomyces tritici (strain R3-111a-1) (Wheat and barley take-all root rot fungus) (Gaeumannomyces graminis var. tritici). AB hydrolase-1 domain-containing protein | Gaeumannomyces tritici |
| gibze-q4i207 | Gibberella zeae (Fusarium graminearum) hypothetical protein | Gibberella zeae |
| glal2-s3dk02 | Glarea lozoyensis (strain ATCC 20868 \/ MF5171). Alpha\/beta-Hydrolase | Glarea lozoyensis |
| grocl-f0xfy2 | Grosmannia clavigera (strain kw1407 \/ UAMH 11150) (Blue stain fungus) (Graphiocladiella clavigera). Toxin biosynthesis protein | Grosmannia clavigera |
| horwe-a0a1z5tqe1 | Hortaea werneckii EXF-2000. AB hydrolase-1 domain-containing protein | Hortaea werneckii EXF-2000 |
| macph-k2r9q4 | Macrophomina phaseolina (strain MS6) (Charcoal rot fungus). AB hydrolase-1 domain-containing protein | Macrophomina phaseolina |
| metrr-a0a166ygn0 | Metarhizium rileyi (strain RCEF 4871) (Nomuraea rileyi). Toxin biosynthesis protein | Metarhizium rileyi |
| neofi-a1cwa6 | Neosartorya fischeri \; Neosartorya fumigata (Aspergillus fumigatus)\; Aspergillus novofumigatus\; Aspergillus lentulus\; Aspergillus turcosus\; Aspergillus thermomutatus\; toxin biosynthesis protein, putative | Neosartorya fischeri |
| neucr-B23L21.350 | Neurospora crassa related to host-specific ak-toxin akt2 | Neurospora crassa |
| penbi-a0a0f7vih7 | Penicillium brasilianum. Putative Toxin biosynthesis protein | Penicillium brasilianum |
| penbr-mpaH |  Penicillium brevicompactum Mycophenolic acid synthesis protein H (peroxisomal acyl-coenzyme A (CoA) hydrolase) mpaH |
Penicillium brevicompactum |
| penen-a0a0a2jay5 | Penicillium expansum (Blue mold rot fungus). AB hydrolase-1 domain-containing protein | Penicillium expansum |
| penit-a0a0a2lf25 | Penicillium italicum (Blue mold). AB hydrolase-1 domain-containing protein | Penicillium italicum |
| peno1-s7zxp5 | Penicillium oxalicum (strain 114-2 \/ CGMCC 5302) (Penicillium decumbens). AB hydrolase-1 domain-containing protein | Penicillium oxalicum |
| penrf-mpah | Penicillium roqueforti (strain FM164). Mycophenolic acid biosynthesis cluster protein H | Penicillium roqueforti |
| penrw-b6huu8 | Penicillium rubens (Penicillium chrysogenum)\; Penicillium flavigenum. Pc22g05640 protein | Penicillium rubens |
| petaa-a0a5n6g1g1 | Petromyces alliaceus (Aspergillus alliaceus). Alpha\/beta-hydrolase | Petromyces alliaceus |
| psed2-l8g569 | Pseudogymnoascus destructans (strain ATCC MYA-4855 \/ 20631-21) (Bat white-nose syndrome fungus) (Geomyces destructans). AB hydrolase-1 domain-containing protein | Pseudogymnoascus destructans |
| psefd-n1qcy3 | Pseudocercospora fijiensis (strain CIRAD86) (Black leaf streak disease fungus) (Mycosphaerella fijiensis). Hydrolase_4 domain-containing protein | Pseudocercospora fijiensis |
| pyrtr-b2vu22 | Pyrenophora tritici-repentis (strain Pt-1C-BFP) (Wheat tan spot fungus) (Drechslera tritici-repentis). AB hydrolase-1 domain-containing protein | Pyrenophora tritici-repentis |
| pyrtt-e3rqw7 | Pyrenophora teres f. teres (strain 0-1) (Barley net blotch fungus) (Drechslera teres f. teres). AB hydrolase-1 domain-containing protein | Pyrenophora teres f. teres |
| sett2-r0i9k2 | Setosphaeria turcica (strain 28A) (Northern leaf blight fungus) (Exserohilum turcicum). AB hydrolase-1 domain-containing protein | Setosphaeria turcica |
| spos1-u7q332 | Sporothrix schenckii (strain ATCC 58251 \/ de Perez 2211183) (Rose-picker's disease fungus). AB hydrolase-1 domain-containing protein | Sporothrix schenckii |
| togmi-r8bkm8 | Togninia minima (strain UCR-PA7) (Esca disease fungus) (Phaeoacremonium aleophilum). Putative toxin biosynthesis protein | Togninia minima |
| xylht-a0a165jir4 | Xylona heveae (strain CBS 132557 \/ TC161). Putative toxin biosynthesis protein | Xylona heveae |
| zymtr-a0a1x7rhi5 | Zymoseptoria tritici (Speckled leaf blotch fungus) (Septoria tritici)\; Zymoseptoria brevis. AB hydrolase-1 domain-containing protein | Zymoseptoria tritici ST99CH_3D7 |
| Gene_locus_frgt | Name | Species |
|---|---|---|
| 9euro-a0a2g7ffj9 | Aspergillus arachidicola. AB hydrolase-1 domain-containing protein | Aspergillus arachidicola |
| 9euro-a0a317x6v5 | Aspergillus sclerotioniger CBS 115572. AB hydrolase-1 domain-containing protein | Aspergillus sclerotioniger CBS 115572 |
| 9euro-a0a319cyn6 | Aspergillus ellipticus CBS 707.79. Uncharacterized protein | Aspergillus ellipticus CBS 707.79 |
| 9euro-a0a395gmd3 | Aspergillus ibericus CBS 121593. Uncharacterized protein | Aspergillus ibericus CBS 121593 |
| 9helo-a0a2s7np25 | Rutstroemia sp. NJR-2017a BBW. Toxin biosynthesis protein | Rutstroemia sp. NJR-2017a BBW |
| altal-act22 | Alternaria alternata (Alternaria rot fungus) (Torula alternata). ACT-toxin biosynthesis protein 2-1 and protein 2-2 | Alternaria alternata |
| altal-aft21 | Alternaria alternata (Alternaria rot fungus) (Torula alternata). AF-toxin biosynthesis protein 2-1 | Alternaria alternata |
| aspc5-a0a1r3rkk0 | Aspergillus carbonarius (strain ITEM 5010). AB hydrolase-1 domain-containing protein | Aspergillus carbonarius |
| aspnc-a2qky7 | Aspergillus niger (strain CBS 513.88 \/ FGSC A1513). Aspergillus niger contig An05c0050, genomic contig | Aspergillus niger |
| aspno-a0a0l1jh60 | Aspergillus nomiae NRRL 13137. AB hydrolase-1 domain-containing protein | Aspergillus nomiae NRRL 13137 |
| aspor-q2txp5 | Aspergillus oryzae predicted protein | Aspergillus oryzae |
| aspoz-a0a1s9d463 | Aspergillus oryzae (Yellow koji mold). Uncharacterized protein | Aspergillus oryzae |
| aspve-a0a1l9pwk1 | Aspergillus versicolor CBS 583.65. Uncharacterized protein | Aspergillus versicolor CBS 583.65 |
| horwe-a0a1z5tce7 | Hortaea werneckii EXF-2000. AB hydrolase-1 domain-containing protein | Hortaea werneckii EXF-2000 |
| Substrate | Chemical Nomenclature | Proteins |
|---|---|---|
| DHDMP | (4R)-7-hydroxy-4,6-dimethyl-4-[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trienyl]-3H-2-benzofuran-1,5-dione | penbr-mpaH |
| Mycophenolic-acid-CoA | S-[2-[3-[[4-[[[5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-2-hydroxy-3,3-dimethylbutanoyl]amino]propanoylamino]ethyl] (E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1H-2-benzofuran-5-yl)-4-methylhex-4-enethioate | penbr-mpaH |
| Inhibitor | Chemical Nomenclature | Proteins |
|---|---|---|
| Mycophenolic-acid | (E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1H-2-benzofuran-5-yl)-4-methylhex-4-enoic acid | penbr-mpaH |
References (1)
| Title : Compartmentalized biosynthesis of mycophenolic acid - Zhang_2019_Proc.Natl.Acad.Sci.U.S.A_116_13305 |
| Author(s) : Zhang W , Du L , Qu Z , Zhang X , Li F , Li Z , Qi F , Wang X , Jiang Y , Men P , Sun J , Cao S , Geng C , Wan X , Liu C , Li S |
| Ref : Proc Natl Acad Sci U S A , 116 :13305 , 2019 |
| Abstract : |
| PubMedSearch : Zhang_2019_Proc.Natl.Acad.Sci.U.S.A_116_13305 |
| PubMedID: 31209052 |
| Gene_locus related to this paper: penbr-mpaH , penbr-mpac |