Penicillium brevicompactum MpaH Hydrolase; part of the gene cluster that mediates the biosynthesis of mycophenolic acid (MPA), the first isolated antibiotic natural product in the world. Farnesyl-5,7-dihydroxy-4,6-dimethylphthalide(DHDMP) substrate of mpaH for transformation into demethylmycophenolic acid (DMMPA). The family is extracted from 6_AlphaBeta_hydrolase.
Interpro : No interpro
PIRSF : No PIRSF
Pdoc : No Pdoc
Pfam : No Pfam
Prints : No Print
EC Number : No EC Number
Structures (2)
Genes Proteins in MpaH family (201)
Fragments of genes in MpaH family (14)
Structures in MpaH family (2)Substrates in MpaH family (2)
Inhibitors in MpaH family (1)
Title : Compartmentalized biosynthesis of mycophenolic acid - Zhang_2019_Proc.Natl.Acad.Sci.U.S.A_116_13305 |
Author(s) : Zhang W , Du L , Qu Z , Zhang X , Li F , Li Z , Qi F , Wang X , Jiang Y , Men P , Sun J , Cao S , Geng C , Wan X , Liu C , Li S |
Ref : Proc Natl Acad Sci U S A , 116 :13305 , 2019 |
Abstract : Zhang_2019_Proc.Natl.Acad.Sci.U.S.A_116_13305 |
ESTHER : Zhang_2019_Proc.Natl.Acad.Sci.U.S.A_116_13305 |
PubMedSearch : Zhang_2019_Proc.Natl.Acad.Sci.U.S.A_116_13305 |
PubMedID: 31209052 |
Gene_locus related to this paper: penbr-mpaH , penbr-mpac |