Delapril
Delapril is a lipophilic, non-sulfhydryl angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity. As a prodrug, delapril is converted to two active metabolites, delapril diacid and 5-hydroxy delapril diacid
General
Type : Drug, Not AlphaBeta Hydrolase target, Pro-Drug, Peptide
Chemical_Nomenclature : 2-[2,3-dihydro-1H-inden-2-yl-[(2S)-2-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]propanoyl]amino]acetic acid
Canonical SMILES : CCOC(=O)[C@H](CCC1=CC=CC=C1)N[C@@H](C)C(=O)N(CC(=O)O)C2CC3=CC=CC=C3C2
InChI : InChI=1S\/C26H32N2O5\/c1-3-33-26(32)23(14-13-19-9-5-4-6-10-19)27-18(2)25(31)28(17-24(29)30)22-15-20-11-7-8-12-21(20)16-22\/h4-12,18,22-23,27H,3,13-17H2,1-2H3,(H,29,30)\/t18-,23-\/m0\/s1
InChIKey : WOUOLAUOZXOLJQ-MBSDFSHPSA-N
Other name(s) : unk-Ala-(indan-2yl)-Gly-OH || Alindapril || W77UAL9THI || 2-[2,3-dihydro-1H-inden-2-yl-[(2S)-2-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]propanoyl]amino]acetic acid || CV-3317 || Glycine, N-(2,3-dihydro-1H-inden-2-yl)-N-(N-(1-(ethoxycarbonyl)-3-phenylpropyl)-L-alanyl)-, (S)- || SCHEMBL34120 || CHEMBL589583 || CHEBI:135735
MW : 452.5
Formula : C26H32N2O5
CAS_number : 83435-66-9
PubChem : 5362116
UniChem : WOUOLAUOZXOLJQ-MBSDFSHPSA-N
Target
Structures : No structure
Families : Carb_B_Chordata
References (1)
| Title : Hydrolytic profile for ester- or amide-linkage by carboxylesterases pI 5.3 and 4.5 from human liver - Takai_1997_Biol.Pharm.Bull_20_869 |
| Author(s) : Takai S , Matsuda A , Usami Y , Adachi T , Sugiyama T , Katagiri Y , Tatematsu M , Hirano K |
| Ref : Biol Pharm Bull , 20 :869 , 1997 |
| Abstract : |
| PubMedSearch : Takai_1997_Biol.Pharm.Bull_20_869 |
| PubMedID: 9300133 |
| Gene_locus related to this paper: human-CES1 , human-CES2 |