Eslicarbazepine-acetate
Eslicarbazepine acetate is the acetate ester of licarbazepine. An anticonvulsant, it is used as an adjunctive therapy for epilepsy by inhibiting repeated neuronal firing and stabilizing the inactivated state of voltage-gated sodium channels, thus preventing their return to the activated state during which seizure activity can occur. It is a dibenzoazepine, a carboxamide and a member of ureas.
General
Type : Drug, Pro-Drug, Benzazepin, Carbamate, Acetate, Carboxamide, Azepane
Chemical_Nomenclature : [(5S)-11-carbamoyl-5,6-dihydrobenzo[b][1]benzazepin-5-yl] acetate
Canonical SMILES : CC(=O)OC1CC2=CC=CC=C2N(C3=CC=CC=C13)C(=O)N
InChI : InChI=1S\/C17H16N2O3\/c1-11(20)22-16-10-12-6-2-4-8-14(12)19(17(18)21)15-9-5-3-7-13(15)16\/h2-9,16H,10H2,1H3,(H2,18,21)\/t16-\/m0\/s1
InChIKey : QIALRBLEEWJACW-INIZCTEOSA-N
Other name(s) : Eslicarbazepine acetate || BIA 2-093 || Aptiom || Zebinix
MW : 296.32
Formula : C17H16N2O3
CAS_number : 236395-14-5
PubChem : 179344
UniChem : QIALRBLEEWJACW-INIZCTEOSA-N
Target
Structures : No structure
Families : Carb_B_Chordata, Arylacetamide_deacetylase
References (3)
| Title : Role of human AADAC on hydrolysis of eslicarbazepine acetate and effects of AADAC genetic polymorphisms on hydrolase activity - Hirosawa_2021_Drug.Metab.Dispos__ |
| Author(s) : Hirosawa K , Fukami T , Tashiro K , Sakai Y , Kisui F , Nakano M , Nakajima M |
| Ref : Drug Metabolism & Disposition: The Biological Fate of Chemicals , : , 2021 |
| Abstract : |
| PubMedSearch : Hirosawa_2021_Drug.Metab.Dispos__ |
| PubMedID: 33446525 |
| Gene_locus related to this paper: human-AADAC |
| Title : Steady-state plasma and cerebrospinal fluid pharmacokinetics and tolerability of eslicarbazepine acetate and oxcarbazepine in healthy volunteers - Nunes_2013_Epilepsia_54_108 |
| Author(s) : Nunes T , Rocha JF , Falcao A , Almeida L , Soares-da-Silva P |
| Ref : Epilepsia , 54 :108 , 2013 |
| Abstract : |
| PubMedSearch : Nunes_2013_Epilepsia_54_108 |
| PubMedID: 22812691 |
| Gene_locus related to this paper: human-AADAC |
| Title : A novel polymorphic allele of human arylacetamide deacetylase leads to decreased enzyme activity - Shimizu_2012_Drug.Metab.Dispos_40_1183 |
| Author(s) : Shimizu M , Fukami T , Kobayashi Y , Takamiya M , Aoki Y , Nakajima M , Yokoi T |
| Ref : Drug Metabolism & Disposition: The Biological Fate of Chemicals , 40 :1183 , 2012 |
| Abstract : |
| PubMedSearch : Shimizu_2012_Drug.Metab.Dispos_40_1183 |
| PubMedID: 22415931 |
| Gene_locus related to this paper: human-AADAC |