Mycophenolate-mofetil
2-morpholinoethyl ester of MPA (mycophenolic acid) In the liver, it is metabolised to mycophenolic acid, an immunosuppressant for which it is a prodrug. It is widely used to prevent tissue rejection following organ transplants as well as for the treatment of certain autoimmune diseases. reversible inhibitor of inosine monophosphate dehydrogenase (IMPDH), an enzyme involved in the de novo synthesis of guanine nucleotides
General
Type : Pro-Drug, Drug, Not A\/B H target, Morpholine, Benzofuran
Chemical_Nomenclature : 2-morpholin-4-ylethyl (E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1H-2-benzofuran-5-yl)-4-methylhex-4-enoate
Canonical SMILES : CC1=C2COC(=O)C2=C(C(=C1OC)CC=C(C)CCC(=O)OCCN3CCOCC3)O
InChI : InChI=1S\/C23H31NO7\/c1-15(5-7-19(25)30-13-10-24-8-11-29-12-9-24)4-6-17-21(26)20-18(14-31-23(20)27)16(2)22(17)28-3\/h4,26H,5-14H2,1-3H3\/b15-4+
InChIKey : RTGDFNSFWBGLEC-SYZQJQIISA-N
Other name(s) : mycophenolate mofetil || CellCept || 115007-34-6 || Myfenax || MMF || CHEBI:8764 || SCHEMBL4195 || CHEMBL1456 || SCHEMBL218782 || CHEBI:93612
MW : 433.5
Formula : C23H31NO7
CAS_number : 128794-94-5
PubChem : 5281078
UniChem : RTGDFNSFWBGLEC-SYZQJQIISA-N
Target
Structures : No structure
Families : Carb_B_Chordata
References (2)
| Title : Difference in substrate specificity of carboxylesterase and arylacetamide deacetylase between dogs and humans - Yoshida_2018_Eur.J.Pharm.Sci_111_167 |
| Author(s) : Yoshida T , Fukami T , Kurokawa T , Gotoh S , Oda A , Nakajima M |
| Ref : Eur J Pharm Sci , 111 :167 , 2018 |
| Abstract : |
| PubMedSearch : Yoshida_2018_Eur.J.Pharm.Sci_111_167 |
| PubMedID: 28966098 |
| Gene_locus related to this paper: canfa-CESDD1 , canfa-f1p6w8 , canlf-e2r2h2 |
| Title : Involvement of carboxylesterase 1 and 2 in the hydrolysis of mycophenolate mofetil - Fujiyama_2010_Drug.Metab.Dispos_38_2210 |
| Author(s) : Fujiyama N , Miura M , Kato S , Sone T , Isobe M , Satoh S |
| Ref : Drug Metabolism & Disposition: The Biological Fate of Chemicals , 38 :2210 , 2010 |
| Abstract : |
| PubMedSearch : Fujiyama_2010_Drug.Metab.Dispos_38_2210 |
| PubMedID: 20823294 |