Quinapril
Quinapril is a prodrug and non-sulfhydryl angiotensin converting enzyme (ACE) inhibitor with antihypertensive activity. Quinapril is hydrolized by carboxylesterases, into its active form quinaprilat, which binds to and inhibits ACE, thereby blocking the conversion of angiotensin I to angiotensin II. This abolishes the potent vasoconstrictive actions of angiotensin II and leads to vasodilatation. Quinapril also causes a decrease in angiotensin II-induced aldosterone secretion by the adrenal cortex, thereby promoting diuresis and natriuresis, and increases bradykinin levels.
General
Type : Isoquinoline, Not A\/B H target, Drug, Pro-Drug, Angiotensin-converting enzyme inhibitor
Chemical_Nomenclature : (3S)-2-[(2S)-2-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]propanoyl]-3,4-dihydro-1H-isoquinoline-3-carboxylic acid
Canonical SMILES : CCOC(=O)C(CCC1=CC=CC=C1)NC(C)C(=O)N2CC3=CC=CC=C3CC2C(=O)O
InChI : InChI=1S\/C25H30N2O5\/c1-3-32-25(31)21(14-13-18-9-5-4-6-10-18)26-17(2)23(28)27-16-20-12-8-7-11-19(20)15-22(27)24(29)30\/h4-12,17,21-22,26H,3,13-16H2,1-2H3,(H,29,30)\/t17-,21-,22-\/m0\/s1
InChIKey : JSDRRTOADPPCHY-HSQYWUDLSA-N
Other name(s) : Quinaprilum || Quinaprilum [Latin] || Quinazil || CHEBI:8713 || CHEMBL1592
MW : 438.51
Formula : C25H30N2O5
CAS_number : 85441-61-8
PubChem : 54892
UniChem : JSDRRTOADPPCHY-HSQYWUDLSA-N
Wikipedia : Quinapril
Target
Structures : No structure
Families : Carb_B_Chordata
References (2)
| Title : Effect of carboxylesterase 1 c.428G >\; A single nucleotide variation on the pharmacokinetics of quinapril and enalapril - Tarkiainen_2015_Br.J.Clin.Pharmacol_80_1131 |
| Author(s) : Tarkiainen EK , Tornio A , Holmberg MT , Launiainen T , Neuvonen PJ , Backman JT , Niemi M |
| Ref : British Journal of Clinical Pharmacology , 80 :1131 , 2015 |
| Abstract : |
| PubMedSearch : Tarkiainen_2015_Br.J.Clin.Pharmacol_80_1131 |
| PubMedID: 25919042 |
| Gene_locus related to this paper: human-CES1 |
| Title : Hydrolytic profile for ester- or amide-linkage by carboxylesterases pI 5.3 and 4.5 from human liver - Takai_1997_Biol.Pharm.Bull_20_869 |
| Author(s) : Takai S , Matsuda A , Usami Y , Adachi T , Sugiyama T , Katagiri Y , Tatematsu M , Hirano K |
| Ref : Biol Pharm Bull , 20 :869 , 1997 |
| Abstract : |
| PubMedSearch : Takai_1997_Biol.Pharm.Bull_20_869 |
| PubMedID: 9300133 |
| Gene_locus related to this paper: human-CES1 , human-CES2 |