Valacyclovir
Valacyclovir is an ester of acyclovir a Herpes Simplex Virus Nucleoside Analog DNA Polymerase Inhibitor. Orally administered, valacyclovir is rapidly converted by Valacyclovir hydrolase a biphenyl hydrolase-like
General
Type : Purine, Drug, Not A\/B H target, Nucleoside
Chemical_Nomenclature : 2-[(2-amino-6-oxo-3H-purin-9-yl)methoxy]ethyl (2S)-2-amino-3-methylbutanoate, 2-[(2-amino-6-oxo-1H-purin-9-yl)methoxy]ethyl (2S)-2-amino-3-methylbutanoate
Canonical SMILES : CC(C)C(C(=O)OCCOCN1C=NC2=C1NC(=NC2=O)N)N || CC(C)C(C(=O)OCCOCN1C=NC2=C1N=C(NC2=O)N)N
InChI : InChI=1S\/C13H20N6O4\/c1-7(2)8(14)12(21)23-4-3-22-6-19-5-16-9-10(19)17-13(15)18-11(9)20\/h5,7-8H,3-4,6,14H2,1-2H3,(H3,15,17,18,20)\/t8-\/m0\/s1
InChIKey : HDOVUKNUBWVHOX-QMMMGPOBSA-N
Other name(s) : Valaciclovir || Valtrex || Zelitrex || ValACV
MW : 324.33
Formula : C13H20N6O4
CAS_number : 124832-26-4
UniChem : HDOVUKNUBWVHOX-QMMMGPOBSA-N
IUPHAR : 4824
Wikipedia : Valacyclovir
Target
Structures : No structure
Families : Valacyclovir-hydrolase
References (5)
| Title : Effect of biphenyl hydrolase-like (BPHL) gene disruption on the intestinal stability, permeability and absorption of valacyclovir in wildtype and Bphl knockout mice - Hu_2018_Biochem.Pharmacol_156_147 |
| Author(s) : Hu Y , Epling D , Shi J , Song F , Tsume Y , Zhu HJ , Amidon GL , Smith DE |
| Ref : Biochemical Pharmacology , 156 :147 , 2018 |
| Abstract : |
| PubMedSearch : Hu_2018_Biochem.Pharmacol_156_147 |
| PubMedID: 30121252 |
| Gene_locus related to this paper: human-BPHL |
| Title : Specificity of a prodrug-activating enzyme hVACVase: the leaving group effect - Sun_2010_Mol.Pharm_7_2362 |
| Author(s) : Sun J , Dahan A , Walls ZF , Lai L , Lee KD , Amidon GL |
| Ref : Mol Pharm , 7 :2362 , 2010 |
| Abstract : |
| PubMedSearch : Sun_2010_Mol.Pharm_7_2362 |
| PubMedID: 21028903 |
| Gene_locus related to this paper: human-BPHL |
| Title : Molecular basis of prodrug activation by human valacyclovirase, an alpha-amino acid ester hydrolase - Lai_2008_J.Biol.Chem_283_9318 |
| Author(s) : Lai L , Xu Z , Zhou J , Lee KD , Amidon GL |
| Ref : Journal of Biological Chemistry , 283 :9318 , 2008 |
| Abstract : |
| PubMedSearch : Lai_2008_J.Biol.Chem_283_9318 |
| PubMedID: 18256025 |
| Gene_locus related to this paper: human-BPHL |
| Title : A novel nucleoside prodrug-activating enzyme: substrate specificity of biphenyl hydrolase-like protein - Kim_2004_Mol.Pharm_1_117 |
| Author(s) : Kim I , Song X , Vig BS , Mittal S , Shin HC , Lorenzi PJ , Amidon GL |
| Ref : Mol Pharm , 1 :117 , 2004 |
| Abstract : |
| PubMedSearch : Kim_2004_Mol.Pharm_1_117 |
| PubMedID: 15832508 |
| Gene_locus related to this paper: human-BPHL |
| Title : Identification of a human valacyclovirase: biphenyl hydrolase-like protein as valacyclovir hydrolase - Kim_2003_J.Biol.Chem_278_25348 |
| Author(s) : Kim I , Chu XY , Kim S , Provoda CJ , Lee KD , Amidon GL |
| Ref : Journal of Biological Chemistry , 278 :25348 , 2003 |
| Abstract : |
| PubMedSearch : Kim_2003_J.Biol.Chem_278_25348 |
| PubMedID: 12732646 |
| Gene_locus related to this paper: human-BPHL |