Valacyclovir-hydrolase

Relationship

Family: Valacyclovir-hydrolase

Block: X

Parent Family: Abhydrolase_6

Comment

Biphenyl hydrolase-like; BPHL, Valacyclovirase, Mucin-associated antigen, MCNAA, Breast epithelial Mucin-associated antigen. Alpha-amino acid ester hydrolase that prefers small, hydrophobic, and aromatic side chains and does not have a stringent requirement for the leaving group other than preferring a primary alcohol. Valacyclovir (VACV) is the 5-prime valyl ester prodrug of acyclovir, an effective antiherpetic drug. VACV is relatively stable in gut lumen while very susceptible to intracellular enzymatic hydrolysis.

Database

Interpro : No interpro

PIRSF : No PIRSF

Pdoc : No Pdoc

Pfam : PF12697 Abhydrolase_6

Prints : No Print

EC Number : No EC Number

Sequences

Peptide in Fasta
Nucleotide in Fasta
Alignment with Multalin Text only
Seed alignment with MAFFT No colour
Alignment with MAFFT No colour
Dendrogram The dnd file

Structures (4)

Genes Proteins in Valacyclovir-hydrolase family (99)

Fragments of genes in Valacyclovir-hydrolase family (9)

Structures in Valacyclovir-hydrolase family (4)

Substrates in Valacyclovir-hydrolase family (2)

Inhibitors in Valacyclovir-hydrolase family (1)

References (8)

Title : Effect of biphenyl hydrolase-like (BPHL) gene disruption on the intestinal stability, permeability and absorption of valacyclovir in wildtype and Bphl knockout mice - Hu_2018_Biochem.Pharmacol_156_147
Author(s) : Hu Y , Epling D , Shi J , Song F , Tsume Y , Zhu HJ , Amidon GL , Smith DE
Ref : Biochemical Pharmacology , 156 :147 , 2018
PubMedID: 30121252
Gene_locus related to this paper: human-BPHL

Title : Specificity of a prodrug-activating enzyme hVACVase: the leaving group effect - Sun_2010_Mol.Pharm_7_2362
Author(s) : Sun J , Dahan A , Walls ZF , Lai L , Lee KD , Amidon GL
Ref : Mol Pharm , 7 :2362 , 2010
PubMedID: 21028903
Gene_locus related to this paper: human-BPHL

Title : Molecular basis of prodrug activation by human valacyclovirase, an alpha-amino acid ester hydrolase - Lai_2008_J.Biol.Chem_283_9318
Author(s) : Lai L , Xu Z , Zhou J , Lee KD , Amidon GL
Ref : Journal of Biological Chemistry , 283 :9318 , 2008
PubMedID: 18256025
Gene_locus related to this paper: human-BPHL

Title : A novel nucleoside prodrug-activating enzyme: substrate specificity of biphenyl hydrolase-like protein - Kim_2004_Mol.Pharm_1_117
Author(s) : Kim I , Song X , Vig BS , Mittal S , Shin HC , Lorenzi PJ , Amidon GL
Ref : Mol Pharm , 1 :117 , 2004
PubMedID: 15832508
Gene_locus related to this paper: human-BPHL

Title : Identification of a human valacyclovirase: biphenyl hydrolase-like protein as valacyclovir hydrolase - Kim_2003_J.Biol.Chem_278_25348
Author(s) : Kim I , Chu XY , Kim S , Provoda CJ , Lee KD , Amidon GL
Ref : Journal of Biological Chemistry , 278 :25348 , 2003
PubMedID: 12732646
Gene_locus related to this paper: human-BPHL

Title : Structural characterization and chromosomal localization of the gene encoding human biphenyl hydrolase-related protein (BPHL) - Puente_1998_Genomics_51_459
Author(s) : Puente XS , Pendas AM , Lopez-Otin C
Ref : Genomics , 51 :459 , 1998
PubMedID: 9721218
Gene_locus related to this paper: human-BPHL

Title : Cloning and expression analysis of a novel human serine hydrolase with sequence similarity to prokaryotic enzymes involved in the degradation of aromatic compounds - Puente_1995_J.Biol.Chem_270_12926
Author(s) : Puente XS , Lopez-Otin C
Ref : Journal of Biological Chemistry , 270 :12926 , 1995
PubMedID: 7759552
Gene_locus related to this paper: human-BPHL

Title : Cloning and sequencing of a complementary DNA encoding a Mr 70,000 human breast epithelial mucin-associated antigen - Larocca_1990_Cancer.Res_50_5925
Author(s) : Larocca D , Peterson JA , Walkup G , Urrea R , Ceriani RL
Ref : Cancer Research , 50 :5925 , 1990
PubMedID: 2393862
Gene_locus related to this paper: human-BPHL