Purine

Purine is a heterocyclic aromatic organic compound that consists of two rings (pyrimidine and imidazole) fused together. It is water-soluble. In nucleic acids, two types of nucleobases are purine derivatives: guanine (G) and adenine (A). Building block for many inhibitors of enzymes

Substrate	Main targeted enzyme families	Type
pRib-ADP	Plant_lipase_EDS1-like	Aminopurin Purine Ribose
pRib-AMP	Plant_lipase_EDS1-like	Aminopurin Purine
ADP-ribose	Plant_lipase_EDS1-like	Aminopurin Not AlphaBeta Hydrolase target Purine Drug Ribose
Tenofovir-alafenamide	Carboxypeptidase_S10 Carb_B_Chordata	Drug Pro-Drug Aminopurin Propionate Purine
Bemnifosbuvir	Carboxypeptidase_S10 Carb_B_Chordata	Pro-Drug Drug Not AlphaBeta Hydrolase target Propionate Purine
Mycophenolic-acid-CoA	MpaH	CoA Natural Benzofuran Aminopurin Purine
3HB-CoA	PHA_synth_I PHA_synth_III_C PHA_synth_II	CoA Aminopurin Purine
Cholyl-CoA	Acyl-CoA_Thioesterase	CoA Aminopurin Phenanthrene Purine
Coenzyme-A	6_AlphaBeta_hydrolase Carb_B_Chordata CIB-CCG1-interacting-factor-B	CoA Aminopurin Purine
Acetyl-CoA	Homoserine_transacetylase AlphaBeta_hydrolase	CoA Aminopurin Purine
Valgancyclovir	Valacyclovir-hydrolase	Purine Drug Not AlphaBeta Hydrolase target
Valacyclovir	Valacyclovir-hydrolase	Purine Drug Not AlphaBeta Hydrolase target Nucleoside
Malonyl-CoA	5_AlphaBeta_hydrolase 6_AlphaBeta_hydrolase ABHD11-Acetyl_transferase	CoA Aminopurin Purine
Palmitoyl-CoA	Acyl-CoA_Thioesterase abh_upf00227 6_AlphaBeta_hydrolase LYsophospholipase_carboxylesterase A85-EsteraseD-FGH MenH_SHCHC Palmitoyl-protein_thioesterase Carb_B_Chordata ABHD11-Acetyl_transferase	CoA Aminopurin Hexadecanoate Palmitate Purine
Oleoyl-CoA	Carboxylesterase Carb_B_Chordata	Natural CoA Aminopurin Purine
pRib-ADP	Plant_lipase_EDS1-like	Aminopurin Purine Ribose
pRib-AMP	Plant_lipase_EDS1-like	Aminopurin Purine
ADP-ribose	Plant_lipase_EDS1-like	Aminopurin Not AlphaBeta Hydrolase target Purine Drug Ribose
Tenofovir-alafenamide	Carboxypeptidase_S10 Carb_B_Chordata	Drug Pro-Drug Aminopurin Propionate Purine
Bemnifosbuvir	Carboxypeptidase_S10 Carb_B_Chordata	Pro-Drug Drug Not AlphaBeta Hydrolase target Propionate Purine
Mycophenolic-acid-CoA	MpaH	CoA Natural Benzofuran Aminopurin Purine
3HB-CoA	PHA_synth_I PHA_synth_III_C PHA_synth_II	CoA Aminopurin Purine
Cholyl-CoA	Acyl-CoA_Thioesterase	CoA Aminopurin Phenanthrene Purine
Coenzyme-A	6_AlphaBeta_hydrolase Carb_B_Chordata CIB-CCG1-interacting-factor-B	CoA Aminopurin Purine
Acetyl-CoA	Homoserine_transacetylase AlphaBeta_hydrolase	CoA Aminopurin Purine
Valgancyclovir	Valacyclovir-hydrolase	Purine Drug Not AlphaBeta Hydrolase target
Valacyclovir	Valacyclovir-hydrolase	Purine Drug Not AlphaBeta Hydrolase target Nucleoside
Malonyl-CoA	5_AlphaBeta_hydrolase 6_AlphaBeta_hydrolase ABHD11-Acetyl_transferase	CoA Aminopurin Purine
Palmitoyl-CoA	Acyl-CoA_Thioesterase abh_upf00227 6_AlphaBeta_hydrolase LYsophospholipase_carboxylesterase A85-EsteraseD-FGH MenH_SHCHC Palmitoyl-protein_thioesterase Carb_B_Chordata ABHD11-Acetyl_transferase	CoA Aminopurin Hexadecanoate Palmitate Purine
Oleoyl-CoA	Carboxylesterase Carb_B_Chordata	Natural CoA Aminopurin Purine
pRib-ADP	Plant_lipase_EDS1-like	Aminopurin Purine Ribose
pRib-AMP	Plant_lipase_EDS1-like	Aminopurin Purine
ADP-ribose	Plant_lipase_EDS1-like	Aminopurin Not AlphaBeta Hydrolase target Purine Drug Ribose
Tenofovir-alafenamide	Carboxypeptidase_S10 Carb_B_Chordata	Drug Pro-Drug Aminopurin Propionate Purine
Bemnifosbuvir	Carboxypeptidase_S10 Carb_B_Chordata	Pro-Drug Drug Not AlphaBeta Hydrolase target Propionate Purine
Mycophenolic-acid-CoA	MpaH	CoA Natural Benzofuran Aminopurin Purine
3HB-CoA	PHA_synth_I PHA_synth_III_C PHA_synth_II	CoA Aminopurin Purine
Cholyl-CoA	Acyl-CoA_Thioesterase	CoA Aminopurin Phenanthrene Purine
Coenzyme-A	6_AlphaBeta_hydrolase Carb_B_Chordata CIB-CCG1-interacting-factor-B	CoA Aminopurin Purine
Acetyl-CoA	Homoserine_transacetylase AlphaBeta_hydrolase	CoA Aminopurin Purine
Valgancyclovir	Valacyclovir-hydrolase	Purine Drug Not AlphaBeta Hydrolase target
Valacyclovir	Valacyclovir-hydrolase	Purine Drug Not AlphaBeta Hydrolase target Nucleoside
Malonyl-CoA	5_AlphaBeta_hydrolase 6_AlphaBeta_hydrolase ABHD11-Acetyl_transferase	CoA Aminopurin Purine
Palmitoyl-CoA	Acyl-CoA_Thioesterase abh_upf00227 6_AlphaBeta_hydrolase LYsophospholipase_carboxylesterase A85-EsteraseD-FGH MenH_SHCHC Palmitoyl-protein_thioesterase Carb_B_Chordata ABHD11-Acetyl_transferase	CoA Aminopurin Hexadecanoate Palmitate Purine
Oleoyl-CoA	Carboxylesterase Carb_B_Chordata	Natural CoA Aminopurin Purine