Valgancyclovir
This is a prodrug of ganciclovir related to valacyclovir
General
Type : Purine, Drug, Not AlphaBeta Hydrolase target
Chemical_Nomenclature : [2-[(2-amino-6-oxo-3H-purin-9-yl)methoxy]-3-hydroxypropyl] (2S)-2-amino-3-methylbutanoate
Canonical SMILES : CC(C)C(C(=O)OCC(CO)OCN1C=NC2=C1NC(=NC2=O)N)N
InChI : InChI=1S\/C14H22N6O5\/c1-7(2)9(15)13(23)24-4-8(3-21)25-6-20-5-17-10-11(20)18-14(16)19-12(10)22\/h5,7-9,21H,3-4,6,15H2,1-2H3,(H3,16,18,19,22)\/t8?,9-\/m0\/s1
InChIKey : WPVFJKSGQUFQAP-GKAPJAKFSA-N
Other name(s) : Cymeval || Valganciclovir [INN:BAN] || Valcyt || Valcyte || UNII-GCU97FKN3R
MW : 354.36
Formula : C14H22N6O5
CAS_number : 175865-60-8
PubChem : 64147
UniChem : WPVFJKSGQUFQAP-GKAPJAKFSA-N
IUPHAR : 4716
Wikipedia : Valgancyclovir
Target
Structures : No structure
Families : Valacyclovir-hydrolase
References (4)
| Title : Effect of biphenyl hydrolase-like (BPHL) gene disruption on the intestinal stability, permeability and absorption of valacyclovir in wildtype and Bphl knockout mice - Hu_2018_Biochem.Pharmacol_156_147 |
| Author(s) : Hu Y , Epling D , Shi J , Song F , Tsume Y , Zhu HJ , Amidon GL , Smith DE |
| Ref : Biochemical Pharmacology , 156 :147 , 2018 |
| Abstract : |
| PubMedSearch : Hu_2018_Biochem.Pharmacol_156_147 |
| PubMedID: 30121252 |
| Gene_locus related to this paper: human-BPHL |
| Title : Specificity of a prodrug-activating enzyme hVACVase: the leaving group effect - Sun_2010_Mol.Pharm_7_2362 |
| Author(s) : Sun J , Dahan A , Walls ZF , Lai L , Lee KD , Amidon GL |
| Ref : Mol Pharm , 7 :2362 , 2010 |
| Abstract : |
| PubMedSearch : Sun_2010_Mol.Pharm_7_2362 |
| PubMedID: 21028903 |
| Gene_locus related to this paper: human-BPHL |
| Title : Molecular basis of prodrug activation by human valacyclovirase, an alpha-amino acid ester hydrolase - Lai_2008_J.Biol.Chem_283_9318 |
| Author(s) : Lai L , Xu Z , Zhou J , Lee KD , Amidon GL |
| Ref : Journal of Biological Chemistry , 283 :9318 , 2008 |
| Abstract : |
| PubMedSearch : Lai_2008_J.Biol.Chem_283_9318 |
| PubMedID: 18256025 |
| Gene_locus related to this paper: human-BPHL |
| Title : A novel nucleoside prodrug-activating enzyme: substrate specificity of biphenyl hydrolase-like protein - Kim_2004_Mol.Pharm_1_117 |
| Author(s) : Kim I , Song X , Vig BS , Mittal S , Shin HC , Lorenzi PJ , Amidon GL |
| Ref : Mol Pharm , 1 :117 , 2004 |
| Abstract : |
| PubMedSearch : Kim_2004_Mol.Pharm_1_117 |
| PubMedID: 15832508 |
| Gene_locus related to this paper: human-BPHL |