Beclomethasone-dipropionate
Beclomethasone dipropionate is a second-generation synthetic corticosteroid agent and a diester of beclomethasone, which is structurally similar to [dexamethasone]. It is a prodrug of an active metabolite beclomethasone 17-monopropionate (17-BMP) which acts on the glucocorticoid receptor. anti-inflammatory drug, an anti-asthmatic drug, a prodrug and an anti-arrhythmia drug. Subbstrate of Arylacyl amidase but not of carboxylesterases and cholinesterases. During absorption, beclomethasone dipropionate is undergoes rapid and extensive hydrolysis mediated by esterases CYP3A to form beclomethasone-17-monopropionate (17-BMP)
General
Type : Drug, Pro-Drug, Not AlphaBeta Hydrolase target, Steroid, Propionate, Phenanthrene
Chemical_Nomenclature : [2-[(8S,9R,10S,11S,13S,14S,16S,17R)-9-chloro-11-hydroxy-10,13,16-trimethyl-3-oxo-17-propanoyloxy-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl]-2-oxoethyl] propanoate
Canonical SMILES : CCC(=O)OCC(=O)C1(C(CC2C1(CC(C3(C2CCC4=CC(=O)C=CC43C)Cl)O)C)C)OC(=O)CC
InChI : InChI=1S\/C28H37ClO7\/c1-6-23(33)35-15-22(32)28(36-24(34)7-2)16(3)12-20-19-9-8-17-13-18(30)10-11-25(17,4)27(19,29)21(31)14-26(20,28)5\/h10-11,13,16,19-21,31H,6-9,12,14-15H2,1-5H3\/t16-,19-,20-,21-,25-,26-,27-,28-\/m0\/s1
InChIKey : KUVIULQEHSCUHY-XYWKZLDCSA-N
Other name(s) : Beclometasone dipropionate || 5534-09-8 || Beclovent || Beconase
Target
Structures : No structure
Families : Arylacetamide_deacetylase
References (1)
| Title : Involvement of esterases in the pulmonary metabolism of beclomethasone dipropionate and the potential influence of cannabis use - Qian_2022_Chem.Biol.Interact__110228 |
| Author(s) : Qian Y , Melchert PW , Markowitz JS |
| Ref : Chemico-Biological Interactions , :110228 , 2022 |
| Abstract : |
| PubMedSearch : Qian_2022_Chem.Biol.Interact__110228 |
| PubMedID: 36283465 |