Type : Pro-Drug || Drug || Not A\/B H target || Sulfur compound || Pyrimidine || Pyrazole
Chemical_Nomenclature : N-methyl-N-[3-[3-(thiophene-2-carbonyl)pyrazolo[1,5-a]pyrimidin-7-yl]phenyl]acetamide
Canonical SMILES : CC(=O)N(C)C1=CC=CC(=C1)C2=CC=NC3=C(C=NN23)C(=O)C4=CC=CS4
InChI : InChI=1S\/C20H16N4O2S\/c1-13(25)23(2)15-6-3-5-14(11-15)17-8-9-21-20-16(12-22-24(17)20)19(26)18-7-4-10-27-18\/h3-12H,1-2H3
InChIKey : CBIAWPMZSFFRGN-UHFFFAOYSA-N
Other name(s) : Indiplon-d3, NBI 34060, NBI-34060, SCHEMBL75094, CHEMBL262075, CHEBI:188583
Families : Arylacetamide_deacetylase
Title : Hydrolase activities of cynomolgus monkey liver microsomes and recombinant CES1, CES2, and AADAC - Honda_2021_Eur.J.Pharm.Sci__105807 |
Author(s) : Honda S , Fukami T , Tsujiguchi T , Zhang Y , Nakano M , Nakajima M |
Ref : Eur J Pharm Sci , :105807 , 2021 |
Abstract : Honda_2021_Eur.J.Pharm.Sci__105807 |
ESTHER : Honda_2021_Eur.J.Pharm.Sci__105807 |
PubMedSearch : Honda_2021_Eur.J.Pharm.Sci__105807 |
PubMedID: 33722734 |
Title : Comparison of substrate specificity among human arylacetamide deacetylase and carboxylesterases - Fukami_2015_Eur.J.Pharm.Sci_78_47 |
Author(s) : Fukami T , Kariya M , Kurokawa T , Iida A , Nakajima M |
Ref : Eur J Pharm Sci , 78 :47 , 2015 |
Abstract : Fukami_2015_Eur.J.Pharm.Sci_78_47 |
ESTHER : Fukami_2015_Eur.J.Pharm.Sci_78_47 |
PubMedSearch : Fukami_2015_Eur.J.Pharm.Sci_78_47 |
PubMedID: 26164127 |
Gene_locus related to this paper: human-AADAC , human-CES1 , human-CES2 |
Title : Indiplon is hydrolyzed by arylacetamide deacetylase in human liver - Shimizu_2014_Drug.Metab.Dispos_42_751 |
Author(s) : Shimizu M , Fukami T , Ito Y , Kurokawa T , Kariya M , Nakajima M , Yokoi T |
Ref : Drug Metabolism & Disposition: The Biological Fate of Chemicals , 42 :751 , 2014 |
Abstract : Shimizu_2014_Drug.Metab.Dispos_42_751 |
ESTHER : Shimizu_2014_Drug.Metab.Dispos_42_751 |
PubMedSearch : Shimizu_2014_Drug.Metab.Dispos_42_751 |
PubMedID: 24464802 |
Title : In vitro metabolism of indiplon and an assessment of its drug interaction potential - Madan_2007_Xenobiotica_37_736 |
Author(s) : Madan A , Fisher A , Jin L , Chapman D , Bozigian HP |
Ref : Xenobiotica , 37 :736 , 2007 |
Abstract : Madan_2007_Xenobiotica_37_736 |
ESTHER : Madan_2007_Xenobiotica_37_736 |
PubMedSearch : Madan_2007_Xenobiotica_37_736 |
PubMedID: 17620220 |