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Substrate Report for: Monoacetyldapsone

Dapsone is an antimalarial, leprostatic drug, antiinfective agent and an anti-inflammatory drug. It inhibits of folic acid synthesis in mycobacterium leprae


General
Type Acetate, Sulfonyl, Sulfur compound, Acetanilide
Chemical_Nomenclature N-[4-(4-aminophenyl)sulfonylphenyl]acetamide
Canonical SMILES CC(=O)NC1=CC=C(C=C1)S(=O)(=O)C2=CC=C(C=C2)N
InChI InChI=1S/C14H14N2O3S/c1-10(17)16-12-4-8-14(9-5-12)20(18,19)13-6-2-11(15)3-7-13/h2-9H,15H2,1H3,(H,16,17)
InChIKey WDOCBIHNYYQINH-UHFFFAOYSA-N
Other name(s) N-Acetyl Dapsone ; N-Acetyldapsone ; MADDS
________________________________________________________________________________________________
MW|290.34
Formula|C14H14N2O3S
CAS_number|565-20-8
PubChem|11257
UniChem|WDOCBIHNYYQINH-UHFFFAOYSA-N
IUPHAR|
Wikipedia|

Target
Families | Monoacetyldapsone ligand of proteins in family: Arylacetamide_deacetylase, Carb_B_Chordata
Protein | human-AADAC, human-CES2

References:
Search PubMed for references concerning: Monoacetyldapsone
    Title: Comparison of substrate specificity among human arylacetamide deacetylase and carboxylesterases
    Fukami T, Kariya M, Kurokawa T, Iida A, Nakajima M
    Ref: Eur J Pharm Sci, 78:47, 2015 : PubMed

            

    Title: Arylacetamide deacetylase activity towards monoacetyldapsone. Species comparison, factors that influence activity, and comparison with 2-acetylaminofluorene and p-nitrophenyl acetate hydrolysis
    Preuss CV, Svensson CK
    Ref: Biochemical Pharmacology, 51:1661, 1996 : PubMed