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Substrate Report for: Tween-80

Model substrate for lipases or phospholipase. but also used as excipient, surface-active agent (detergent, emulsifier).



General
Type: Polysorbate, Detergent
Chemical_Nomenclature: 2-[2-[3,4-bis(2-hydroxyethoxy)oxolan-2-yl]-2-(2-hydroxyethoxy)ethoxy]ethyl (E)-octadec-9-enoate
Canonical SMILES: CCCCCCCCC=CCCCCCCCC(=O)OCCOCC(C1C(C(CO1)OCCO)OCCO)OCCO
InChI: InChI=1S/C32H60O10/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-30(36)40-25-24-37-26-28(38-21-18-33)32-31(41-23-20-35)29(27-42-32)39-22-19-34/h9-10,28-29,31-35H,2-8,11-27H2,1H3/b10-9+
InChIKey: HDTIFOGXOGLRCB-MDZDMXLPSA-N
Other name(s): Tween 80 ; Glycol (polysorbate 80) ; Polysorbate-81 ; Polyoxyethylene sorbitan oleate ; Polyethylene oxide sorbitan mono-oleate ; Polyoxyethylene (20) sorbitan monooleate ; AC1NQZCF
MW: 604.82
Formula: C32H60O10
CAS_number:
PubChem: 5281955, 5284448
IUPHAR:
Wikipedia:

Target families
Tween-80 ligand of proteins in family: Carb_B_Chordata, PAF-Acetylhydrolase
No structure

Protein target

References
Search PubMed for references concerning: Tween-80
    Title: Profiling Active Enzymes for Polysorbate Degradation in Biotherapeutics by Activity-Based Protein Profiling
    Li X, Chandra D, Letarte S, Adam GC, Welch J, Yang RS, Rivera S, Bodea S, Dow A and Richardson DD <2 more author(s)>
    Ref: Analytical Chemistry, 93:8161, 2021 : PubMed

            

    Title: Rapid Polysorbate 80 Degradation by Liver Carboxylesterase in a Monoclonal Antibody Formulated Drug Substance at Early Stage Development
    Zhang S, Xiao H, Molden R, Qiu H, Li N
    Ref: J Pharm Sci, 109:3300, 2020 : PubMed

            

    Title: Hydrolysis of Polysorbate 20 and 80 by a Range of Carboxylester Hydrolases
    McShan AC, Kei P, Ji JA, Kim DC, Wang YJ
    Ref: PDA J Pharm Sci Technol, 70:332, 2016 : PubMed