Cyclooxygenase-2 (COX-2) inhibitors are nonsteroidal anti-inflammatory drugs (NSAIDs) the treduce pain and inflammation with fewer stomach issues than traditional NSAIDs, but carry risks for heart attack and stroke. They work by stopping the production of prostaglandins that cause inflammation but spare COX-1, which protects the stomach lining. Used as building blocks of Multi-target drug ligand MTDL