| Title : Engineered alpha4beta2 nicotinic acetylcholine receptors as models for measuring agonist binding and effect at the orthosteric low-affinity alpha4-alpha4 interface - Ahring_2015_Neuropharmacol_92_135 |
| Author(s) : Ahring PK , Olsen JA , Nielsen EO , Peters D , Pedersen MH , Rohde LA , Kastrup JS , Shahsavar A , Indurthi DC , Chebib M , Gajhede M , Balle T |
| Ref : Neuropharmacology , 92 :135 , 2015 |
| Abstract : |
| PubMedSearch : Ahring_2015_Neuropharmacol_92_135 |
| PubMedID: 25595102 |
| Title : Poster: Modulation of alpha4beta2 NACHRs via an extracellular binding site: Structural studies and novel engineered receptors to aid drug discovery - |
| Author(s) : Balle T , Olsen JA , Shahsavar A , Kastrup JS , Peter D , Gajhede M , Ahring PK |
| Ref : Biochemical Pharmacology , 97 :623 , 2015 |
| PubMedID: |
| Title : Structural and functional studies of the modulator NS9283 reveal agonist-like mechanism of action at alpha4beta2 nicotinic acetylcholine receptors - Olsen_2014_J.Biol.Chem_289_24911 |
| Author(s) : Olsen JA , Ahring PK , Kastrup JS , Gajhede M , Balle T |
| Ref : Journal of Biological Chemistry , 289 :24911 , 2014 |
| Abstract : |
| PubMedSearch : Olsen_2014_J.Biol.Chem_289_24911 |
| PubMedID: 24982426 |
| Title : Molecular recognition of the neurotransmitter acetylcholine by an acetylcholine binding protein reveals determinants of binding to nicotinic acetylcholine receptors - Olsen_2014_PLoS.One_9_e91232 |
| Author(s) : Olsen JA , Balle T , Gajhede M , Ahring PK , Kastrup JS |
| Ref : PLoS ONE , 9 :e91232 , 2014 |
| Abstract : |
| PubMedSearch : Olsen_2014_PLoS.One_9_e91232 |
| PubMedID: 24637639 |
| Title : Synthesis, pharmacology, and biostructural characterization of novel alpha4beta2 nicotinic acetylcholine receptor agonists - Ussing_2013_J.Med.Chem_56_940 |
| Author(s) : Ussing CA , Hansen CP , Petersen JG , Jensen AA , Rohde LA , Ahring PK , Nielsen EO , Kastrup JS , Gajhede M , Frolund B , Balle T |
| Ref : Journal of Medicinal Chemistry , 56 :940 , 2013 |
| Abstract : |
| PubMedSearch : Ussing_2013_J.Med.Chem_56_940 |
| PubMedID: 23256554 |
| Title : Molecular determinants of subtype-selective efficacies of cytisine and the novel compound NS3861 at heteromeric nicotinic acetylcholine receptors - Harpsoe_2013_J.Biol.Chem_288_2559 |
| Author(s) : Harpsoe K , Hald H , Timmermann DB , Jensen ML , Dyhring T , Nielsen EO , Peters D , Balle T , Gajhede M , Kastrup JS , Ahring PK |
| Ref : Journal of Biological Chemistry , 288 :2559 , 2013 |
| Abstract : |
| PubMedSearch : Harpsoe_2013_J.Biol.Chem_288_2559 |
| PubMedID: 23229547 |
| Title : Two distinct allosteric binding sites at alpha4beta2 nicotinic acetylcholine receptors revealed by NS206 and NS9283 give unique insights to binding activity-associated linkage at Cys-loop receptors - Olsen_2013_J.Biol.Chem_288_35997 |
| Author(s) : Olsen JA , Kastrup JS , Peters D , Gajhede M , Balle T , Ahring PK |
| Ref : Journal of Biological Chemistry , 288 :35997 , 2013 |
| Abstract : |
| PubMedSearch : Olsen_2013_J.Biol.Chem_288_35997 |
| PubMedID: 24169695 |
| Title : Crystal structure of Lymnaea stagnalis AChBP complexed with the potent nAChR antagonist DHbetaE suggests a unique mode of antagonism - Shahsavar_2012_PLoS.One_7_e40757 |
| Author(s) : Shahsavar A , Kastrup JS , Nielsen EO , Kristensen JL , Gajhede M , Balle T |
| Ref : PLoS ONE , 7 :e40757 , 2012 |
| Abstract : |
| PubMedSearch : Shahsavar_2012_PLoS.One_7_e40757 |
| PubMedID: 22927902 |
| Title : Intersubunit bridge formation governs agonist efficacy at nicotinic acetylcholine alpha4beta2 receptors: unique role of halogen bonding revealed - Rohde_2012_J.Biol.Chem_287_4248 |
| Author(s) : Rohde LA , Ahring PK , Jensen ML , Nielsen EO , Peters D , Helgstrand C , Krintel C , Harpsoe K , Gajhede M , Kastrup JS , Balle T |
| Ref : Journal of Biological Chemistry , 287 :4248 , 2012 |
| Abstract : |
| PubMedSearch : Rohde_2012_J.Biol.Chem_287_4248 |
| PubMedID: 22170047 |