Full name : Ahring Philip K
First name : Philip K
Mail : Faculty of Pharmacy, The University of Sydney, NSW 2006, Australia\; Saniona AB, 2750 Ballerup
Zip Code :
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Country : Denmark
Email : pka@aniona.com
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Comment
| Title : Heterologous expression of concatenated nicotinic ACh receptors: Pros and cons of subunit concatenation and recommendations for construct designs - Liao_2020_Br.J.Pharmacol_177_4275 |
| Author(s) : Liao VWY , Kusay AS , Balle T , Ahring PK |
| Ref : British Journal of Pharmacology , 177 :4275 , 2020 |
| Abstract : |
| PubMedSearch : Liao_2020_Br.J.Pharmacol_177_4275 |
| PubMedID: 32627170 |
| Title : Structure-Based Discovery of Dual-Target Hits for Acetylcholinesterase and the alpha7 Nicotinic Acetylcholine Receptors: In Silico Studies and In Vitro Confirmation - Oddsson_2020_Molecules_25_ |
| Author(s) : Oddsson S , Kowal NM , Ahring PK , Olafsdottir ES , Balle T |
| Ref : Molecules , 25 : , 2020 |
| Abstract : |
| PubMedSearch : Oddsson_2020_Molecules_25_ |
| PubMedID: 32580406 |
| Title : Novel Approach for the Search for Chemical Scaffolds with Dual Activity with Acetylcholinesterase and the alpha7 Nicotinic Acetylcholine Receptor-A Perspective for the Treatment of Neurodegenerative Disorders - Kowal_2019_Molecules_24_ |
| Author(s) : Kowal NM , Indurthi DC , Ahring PK , Chebib M , Olafsdottir ES , Balle T |
| Ref : Molecules , 24 : , 2019 |
| Abstract : |
| PubMedSearch : Kowal_2019_Molecules_24_ |
| PubMedID: 30691196 |
| Title : Galantamine is not a positive allosteric modulator of human alpha4beta2 or alpha7 nicotinic acetylcholine receptors - Kowal_2018_Br.J.Pharmacol_175_2911 |
| Author(s) : Kowal NM , Ahring PK , Liao VWY , Indurti DC , Harvey BS , O'Connor SM , Chebib M , Olafsdottir ES , Balle T |
| Ref : British Journal of Pharmacology , 175 :2911 , 2018 |
| Abstract : |
| PubMedSearch : Kowal_2018_Br.J.Pharmacol_175_2911 |
| PubMedID: 29669164 |
| Title : Engineered alpha4beta2 nicotinic acetylcholine receptors as models for measuring agonist binding and effect at the orthosteric low-affinity alpha4-alpha4 interface - Ahring_2015_Neuropharmacol_92_135 |
| Author(s) : Ahring PK , Olsen JA , Nielsen EO , Peters D , Pedersen MH , Rohde LA , Kastrup JS , Shahsavar A , Indurthi DC , Chebib M , Gajhede M , Balle T |
| Ref : Neuropharmacology , 92 :135 , 2015 |
| Abstract : |
| PubMedSearch : Ahring_2015_Neuropharmacol_92_135 |
| PubMedID: 25595102 |
| Title : Poster: Exploring the structure activity relationships of halogen containing N-(pyridin-3-yl)-piperazines and homopiperazines at alpha4beta2 nAChRs - |
| Author(s) : Rudner-Varga V , Ahring PK , Indurthi D , Peters D , Orton H , Kanizaj N , McLeod MD , Chebib M , Balle T |
| Ref : Biochemical Pharmacology , 97 :623 , 2015 |
| PubMedID: |
| Title : Poster: Modulation of alpha4beta2 NACHRs via an extracellular binding site: Structural studies and novel engineered receptors to aid drug discovery - |
| Author(s) : Balle T , Olsen JA , Shahsavar A , Kastrup JS , Peter D , Gajhede M , Ahring PK |
| Ref : Biochemical Pharmacology , 97 :623 , 2015 |
| PubMedID: |
| Title : Poster: Exploiting ligand selectivity to understand allosteric receptor opening - |
| Author(s) : Indurthi DC , Balle T , Ahring PK , Chebib M , Lewis TM , Absalom NL |
| Ref : Biochemical Pharmacology , 97 :624 , 2015 |
| PubMedID: |
| Title : Biophysical and pharmacological characterization of alpha6-containing nicotinic acetylcholine receptors expressed in HEK293 cells - Rasmussen_2014_Brain.Res_1542_1 |
| Author(s) : Rasmussen AH , Strobaek D , Dyhring T , Jensen ML , Peters D , Grunnet M , Timmermann DB , Ahring PK |
| Ref : Brain Research , 1542 :1 , 2014 |
| Abstract : |
| PubMedSearch : Rasmussen_2014_Brain.Res_1542_1 |
| PubMedID: 24157862 |
| Title : Structural and functional studies of the modulator NS9283 reveal agonist-like mechanism of action at alpha4beta2 nicotinic acetylcholine receptors - Olsen_2014_J.Biol.Chem_289_24911 |
| Author(s) : Olsen JA , Ahring PK , Kastrup JS , Gajhede M , Balle T |
| Ref : Journal of Biological Chemistry , 289 :24911 , 2014 |
| Abstract : |
| PubMedSearch : Olsen_2014_J.Biol.Chem_289_24911 |
| PubMedID: 24982426 |
| Title : Molecular recognition of the neurotransmitter acetylcholine by an acetylcholine binding protein reveals determinants of binding to nicotinic acetylcholine receptors - Olsen_2014_PLoS.One_9_e91232 |
| Author(s) : Olsen JA , Balle T , Gajhede M , Ahring PK , Kastrup JS |
| Ref : PLoS ONE , 9 :e91232 , 2014 |
| Abstract : |
| PubMedSearch : Olsen_2014_PLoS.One_9_e91232 |
| PubMedID: 24637639 |
| Title : Synthesis, pharmacology, and biostructural characterization of novel alpha4beta2 nicotinic acetylcholine receptor agonists - Ussing_2013_J.Med.Chem_56_940 |
| Author(s) : Ussing CA , Hansen CP , Petersen JG , Jensen AA , Rohde LA , Ahring PK , Nielsen EO , Kastrup JS , Gajhede M , Frolund B , Balle T |
| Ref : Journal of Medicinal Chemistry , 56 :940 , 2013 |
| Abstract : |
| PubMedSearch : Ussing_2013_J.Med.Chem_56_940 |
| PubMedID: 23256554 |
| Title : Molecular determinants of subtype-selective efficacies of cytisine and the novel compound NS3861 at heteromeric nicotinic acetylcholine receptors - Harpsoe_2013_J.Biol.Chem_288_2559 |
| Author(s) : Harpsoe K , Hald H , Timmermann DB , Jensen ML , Dyhring T , Nielsen EO , Peters D , Balle T , Gajhede M , Kastrup JS , Ahring PK |
| Ref : Journal of Biological Chemistry , 288 :2559 , 2013 |
| Abstract : |
| PubMedSearch : Harpsoe_2013_J.Biol.Chem_288_2559 |
| PubMedID: 23229547 |
| Title : Two distinct allosteric binding sites at alpha4beta2 nicotinic acetylcholine receptors revealed by NS206 and NS9283 give unique insights to binding activity-associated linkage at Cys-loop receptors - Olsen_2013_J.Biol.Chem_288_35997 |
| Author(s) : Olsen JA , Kastrup JS , Peters D , Gajhede M , Balle T , Ahring PK |
| Ref : Journal of Biological Chemistry , 288 :35997 , 2013 |
| Abstract : |
| PubMedSearch : Olsen_2013_J.Biol.Chem_288_35997 |
| PubMedID: 24169695 |
| Title : Intersubunit bridge formation governs agonist efficacy at nicotinic acetylcholine alpha4beta2 receptors: unique role of halogen bonding revealed - Rohde_2012_J.Biol.Chem_287_4248 |
| Author(s) : Rohde LA , Ahring PK , Jensen ML , Nielsen EO , Peters D , Helgstrand C , Krintel C , Harpsoe K , Gajhede M , Kastrup JS , Balle T |
| Ref : Journal of Biological Chemistry , 287 :4248 , 2012 |
| Abstract : |
| PubMedSearch : Rohde_2012_J.Biol.Chem_287_4248 |
| PubMedID: 22170047 |
| Title : Augmentation of cognitive function by NS9283, a stoichiometry-dependent positive allosteric modulator of alpha2- and alpha4-containing nicotinic acetylcholine receptors - Timmermann_2012_Br.J.Pharmacol_167_164 |
| Author(s) : Timmermann DB , Sandager-Nielsen K , Dyhring T , Smith M , Jacobsen AM , Nielsen EO , Grunnet M , Christensen JK , Peters D , Kohlhaas KL , Olsen GM , Ahring PK |
| Ref : British Journal of Pharmacology , 167 :164 , 2012 |
| Abstract : |
| PubMedSearch : Timmermann_2012_Br.J.Pharmacol_167_164 |
| PubMedID: 22506660 |
| Title : Discovery of a novel allosteric modulator of 5-HT3 receptors: inhibition and potentiation of Cys-loop receptor signaling through a conserved transmembrane intersubunit site - Trattnig_2012_J.Biol.Chem_287_25241 |
| Author(s) : Trattnig SM , Harpsoe K , Thygesen SB , Rahr LM , Ahring PK , Balle T , Jensen AA |
| Ref : Journal of Biological Chemistry , 287 :25241 , 2012 |
| Abstract : |
| PubMedSearch : Trattnig_2012_J.Biol.Chem_287_25241 |
| PubMedID: 22589534 |
| Title : Poster: Differential allosteric modulation of high- and low-sensitivity forms of the alpha4\/beta2 nAChR: Evidence for distinct modulator binding sites - |
| Author(s) : Timmermann DB , Grunnet M , Peters D , Ahring PK |
| Ref : Biochemical Pharmacology , 82 :1031 , 2011 |
| PubMedID: |
| Title : Unraveling the high- and low-sensitivity agonist responses of nicotinic acetylcholine receptors - Harpsoe_2011_J.Neurosci_31_10759 |
| Author(s) : Harpsoe K , Ahring PK , Christensen JK , Jensen ML , Peters D , Balle T |
| Ref : Journal of Neuroscience , 31 :10759 , 2011 |
| Abstract : |
| PubMedSearch : Harpsoe_2011_J.Neurosci_31_10759 |
| PubMedID: 21795528 |
| Title : Poster: The (alpha4)3(\/beta2)2 nAChR has a benzodiazepine-like modulatory binding site in the alphaalpha-subunit interface as revealed by studies with NS9283 - |
| Author(s) : Ahring PK , Peters D , Christensen JK , Jensen ML , Harpsoe K , Balle T |
| Ref : Biochemical Pharmacology , 82 :1029 , 2011 |
| PubMedID: |
| Title : Poster: Electrophysiological characterization of NS9283, a novel positive allosteric modulator of alpha4\/beta2 nicotinic receptors - |
| Author(s) : Grupe M , Grunnet M , Christensen JK , Jensen AA , Ahring PK |
| Ref : Biochemical Pharmacology , 82 :1030 , 2011 |
| PubMedID: |
| Title : In vitro pharmacological characterization of a novel selective alpha7 neuronal nicotinic acetylcholine receptor agonist ABT-107 - Malysz_2010_J.Pharmacol.Exp.Ther_334_863 |
| Author(s) : Malysz J , Anderson DJ , Gronlien JH , Ji J , Bunnelle WH , Hakerud M , Thorin-Hagene K , Ween H , Helfrich R , Hu M , Gubbins E , Gopalakrishnan S , Puttfarcken PS , Briggs CA , Li J , Meyer MD , Dyhring T , Ahring PK , Nielsen EO , Peters D , Timmermann DB , Gopalakrishnan M |
| Ref : Journal of Pharmacology & Experimental Therapeutics , 334 :863 , 2010 |
| Abstract : |
| PubMedSearch : Malysz_2010_J.Pharmacol.Exp.Ther_334_863 |
| PubMedID: 20504915 |
| Title : Poster: In vitro pharmacological profile of a novel alpha4\/beta2 positive allosteric modulator NS9283 (A-969933) - |
| Author(s) : Malysz J , Dyhring T , Ahring PK , Olsen GM , Peters D , Gronlien JH , Wetterstrand C , Ween H , Haakerud M , Thorin-Hagene K , Andersen E , Anderson DJ , Hu M , Kroeger PE , Lee CHL , Gopalakrishnan M , Timmermann DB |
| Ref : Biochemical Pharmacology , 78 :919 , 2009 |
| PubMedID: |
| Title : Complementary three-dimensional quantitative structure-activity relationship modeling of binding affinity and functional potency: a study on alpha4beta2 nicotinic ligands - Tosco_2009_J.Med.Chem_52_2311 |
| Author(s) : Tosco P , Ahring PK , Dyhring T , Peters D , Harpsoe K , Liljefors T , Balle T |
| Ref : Journal of Medicinal Chemistry , 52 :2311 , 2009 |
| Abstract : |
| PubMedSearch : Tosco_2009_J.Med.Chem_52_2311 |
| PubMedID: 19301898 |
| Title : Evaluation of alpha7 nicotinic acetylcholine receptor agonists and positive allosteric modulators using the parallel oocyte electrophysiology test station - Malysz_2009_Assay.Drug.Dev.Technol_7_374 |
| Author(s) : Malysz J , Gronlien JH , Timmermann DB , Hakerud M , Thorin-Hagene K , Ween H , Trumbull JD , Xiong Y , Briggs CA , Ahring PK , Dyhring T , Gopalakrishnan M |
| Ref : Assay Drug Dev Technol , 7 :374 , 2009 |
| Abstract : |
| PubMedSearch : Malysz_2009_Assay.Drug.Dev.Technol_7_374 |
| PubMedID: 19689206 |
| Title : A-366833: a novel nicotinonitrile-substituted 3,6-diazabicyclo[3.2.0]-heptane alpha4beta2 nicotinic acetylcholine receptor selective agonist: Synthesis, analgesic efficacy and tolerability profile in animal models - Ji_2007_Biochem.Pharmacol_74(8)_1253 |
| Author(s) : Ji J , Bunnelle WH , Anderson DJ , Faltynek C , Dyhring T , Ahring PK , Rueter LE , Curzon P , Buckley MJ , Marsh KC , Kempf-Grote A , Meyer MD |
| Ref : Biochemical Pharmacology , 74 :1253 , 2007 |
| Abstract : |
| PubMedSearch : Ji_2007_Biochem.Pharmacol_74(8)_1253 |
| PubMedID: 17854775 |
| Title : An allosteric modulator of the alpha7 nicotinic acetylcholine receptor possessing cognition-enhancing properties in vivo - Timmermann_2007_J.Pharmacol.Exp.Ther_323_294 |
| Author(s) : Timmermann DB , Gronlien JH , Kohlhaas KL , Nielsen EO , Dam E , Jorgensen TD , Ahring PK , Peters D , Holst D , Christensen JK , Malysz J , Briggs CA , Gopalakrishnan M , Olsen GM |
| Ref : Journal of Pharmacology & Experimental Therapeutics , 323 :294 , 2007 |
| Abstract : |
| PubMedSearch : Timmermann_2007_J.Pharmacol.Exp.Ther_323_294 |
| PubMedID: 17625074 |
| Title : The beta subunit determines the ion selectivity of the GABAA receptor - Jensen_2002_J.Biol.Chem_277_41438 |
| Author(s) : Jensen ML , Timmermann DB , Johansen TH , Schousboe A , Varming T , Ahring PK |
| Ref : Journal of Biological Chemistry , 277 :41438 , 2002 |
| Abstract : |
| PubMedSearch : Jensen_2002_J.Biol.Chem_277_41438 |
| PubMedID: 12177063 |