Hegele RA

References (28)

Title : Phenotype in Individuals with Heterozygous Rare Variants in LIPC Encoding Hepatic Lipase - Jacob_2024_Int.J.Mol.Sci_25_11445
Author(s) : Jacob EO , Wang J , McIntyre AD , Hegele RA
Ref : Int J Mol Sci , 25 :11445 , 2024
Abstract :
PubMedSearch : Jacob_2024_Int.J.Mol.Sci_25_11445
PubMedID: 39518997
Gene_locus related to this paper: human-LIPC

Title : Soluble Epoxide Hydrolase Derived Linoleic Acid Oxylipins, Small Vessel Disease Markers, and Neurodegeneration in Stroke - Yu_2023_J.Am.Heart.Assoc_12_e026901
Author(s) : Yu D , Liang N , Zebarth J , Shen Q , Ozzoude M , Goubran M , Rabin JS , Ramirez J , Scott CJM , Gao F , Bartha R , Symons S , Haddad SMH , Berezuk C , Tan B , Kwan D , Hegele RA , Dilliott AA , Nanayakkara ND , Binns MA , Beaton D , Arnott SR , Lawrence-Dewar JM , Hassan A , Dowlatshahi D , Mandzia J , Sahlas D , Casaubon L , Saposnik G , Otoki Y , Lanctot KL , Masellis M , Black SE , Swartz RH , Taha AY , Swardfager W
Ref : J Am Heart Assoc , 12 :e026901 , 2023
Abstract :
PubMedSearch : Yu_2023_J.Am.Heart.Assoc_12_e026901
PubMedID: 36583428

Title : The longitudinal triglyceride phenotype in heterozygotes with LPL pathogenic variants - Perera_2022_J.Clin.Lipidol__
Author(s) : Perera SD , Wang J , McIntyre AD , Dron JS , Hegele RA
Ref : J Clin Lipidol , : , 2022
Abstract :
PubMedSearch : Perera_2022_J.Clin.Lipidol__
PubMedID: 36476373

Title : Volanesorsen for treatment of familial chylomicronemia syndrome - Lazarte_2021_Expert.Rev.Cardiovasc.Ther_19_685
Author(s) : Lazarte J , Hegele RA
Ref : Expert Rev Cardiovasc Ther , 19 :685 , 2021
Abstract :
PubMedSearch : Lazarte_2021_Expert.Rev.Cardiovasc.Ther_19_685
PubMedID: 34261380

Title : Novel therapeutics in hypertriglyceridemia - Gryn_2015_Curr.Opin.Lipidol_26_484
Author(s) : Gryn SE , Hegele RA
Ref : Curr Opin Lipidol , 26 :484 , 2015
Abstract :
PubMedSearch : Gryn_2015_Curr.Opin.Lipidol_26_484
PubMedID: 26780002

Title : Severe Hypertriglyceridemia due to a novel p.Q240H mutation in the Lipoprotein Lipase gene - Soto_2015_Lipids.Health.Dis_14_102
Author(s) : Soto AG , McIntyre A , Agrawal S , Bialo SR , Hegele RA , Boney CM
Ref : Lipids Health Dis , 14 :102 , 2015
Abstract :
PubMedSearch : Soto_2015_Lipids.Health.Dis_14_102
PubMedID: 26337181
Gene_locus related to this paper: human-LPL

Title : Partial lipodystrophy associated with muscular dystrophy of unknown genetic origin -
Author(s) : Carboni N , Brancati F , Cocco E , Solla E , D'Apice MR , Mateddu A , McIntyre A , Fadda E , Mura M , Lattanzi G , Piras R , Maioli MA , Marrosu G , Novelli G , Marrosu MG , Hegele RA
Ref : Muscle & Nerve , 49 :928 , 2014
PubMedID: 24375490
Gene_locus related to this paper: human-LIPE

Title : A novel LIPE nonsense mutation found using exome sequencing in siblings with late-onset familial partial lipodystrophy - Farhan_2014_Can.J.Cardiol_30_1649
Author(s) : Farhan SM , Robinson JF , McIntyre AD , Marrosu MG , Ticca AF , Loddo S , Carboni N , Brancati F , Hegele RA
Ref : Can J Cardiol , 30 :1649 , 2014
Abstract :
PubMedSearch : Farhan_2014_Can.J.Cardiol_30_1649
PubMedID: 25475467
Gene_locus related to this paper: human-LIPE

Title : Mutations in LPL, APOC2, APOA5, GPIHBP1 and LMF1 in patients with severe hypertriglyceridaemia - Surendran_2012_J.Intern.Med_272_185
Author(s) : Surendran RP , Visser ME , Heemelaar S , Wang J , Peter J , Defesche JC , Kuivenhoven JA , Hosseini M , Peterfy M , Kastelein JJ , Johansen CT , Hegele RA , Stroes ES , Dallinga-Thie GM
Ref : J Intern Med , 272 :185 , 2012
Abstract :
PubMedSearch : Surendran_2012_J.Intern.Med_272_185
PubMedID: 22239554
Gene_locus related to this paper: human-LPL

Title : Loss-of-function variants in endothelial lipase are a cause of elevated HDL cholesterol in humans - Edmondson_2009_J.Clin.Invest_119_1042
Author(s) : Edmondson AC , Brown RJ , Kathiresan S , Cupples LA , Demissie S , Manning AK , Jensen MK , Rimm EB , Wang J , Rodrigues A , Bamba V , Khetarpal SA , Wolfe ML , Derohannessian S , Li M , Reilly MP , Aberle J , Evans D , Hegele RA , Rader DJ
Ref : J Clinical Investigation , 119 :1042 , 2009
Abstract :
PubMedSearch : Edmondson_2009_J.Clin.Invest_119_1042
PubMedID: 19287092
Gene_locus related to this paper: human-LIPG

Title : Novel LPL mutations associated with lipoprotein lipase deficiency: two case reports and a literature review - Rahalkar_2009_Can.J.Physiol.Pharmacol_87_151
Author(s) : Rahalkar AR , Giffen F , Har B , Ho J , Morrison KM , Hill J , Wang J , Hegele RA , Joy T
Ref : Canadian Journal of Physiology & Pharmacology , 87 :151 , 2009
Abstract :
PubMedSearch : Rahalkar_2009_Can.J.Physiol.Pharmacol_87_151
PubMedID: 19295657
Gene_locus related to this paper: human-LPL

Title : Stability of lipids on peritoneal dialysis in a patient with familial LCAT deficiency -
Author(s) : Weber CL , Frohlich J , Wang J , Hegele RA , Chan-Yan C
Ref : Nephrol Dial Transplant , 22 :2084 , 2007
PubMedID: 17452402

Title : Resequencing genomic DNA of patients with severe hypertriglyceridemia (MIM 144650) - Wang_2007_Arterioscler.Thromb.Vasc.Biol_27_2450
Author(s) : Wang J , Cao H , Ban MR , Kennedy BA , Zhu S , Anand S , Yusuf S , Pollex RL , Hegele RA
Ref : Arterioscler Thromb Vasc Biol , 27 :2450 , 2007
Abstract :
PubMedSearch : Wang_2007_Arterioscler.Thromb.Vasc.Biol_27_2450
PubMedID: 17717288
Gene_locus related to this paper: human-LPL

Title : Gene therapy with lipoprotein lipase variant S447X -
Author(s) : Hegele RA
Ref : Arterioscler Thromb Vasc Biol , 26 :e25\; author reply e25 , 2006
PubMedID: 16484602

Title : Treatment of dyslipidemia with lovastatin and ezetimibe in an adolescent with cholesterol ester storage disease - Tadiboyina_2005_Lipids.Health.Dis_4_26
Author(s) : Tadiboyina VT , Liu DM , Miskie BA , Wang J , Hegele RA
Ref : Lipids Health Dis , 4 :26 , 2005
Abstract :
PubMedSearch : Tadiboyina_2005_Lipids.Health.Dis_4_26
PubMedID: 16255772

Title : Identification of a novel lipase gene mutated in lpd mice with hypertriglyceridemia and associated with dyslipidemia in humans - Wen_2003_Hum.Mol.Genet_12_1131
Author(s) : Wen XY , Hegele RA , Wang J , Wang DY , Cheung J , Wilson M , Yahyapour M , Bai Y , Zhuang L , Skaug J , Young TK , Connelly PW , Koop BF , Tsui LC , Stewart AK
Ref : Hum Mol Genet , 12 :1131 , 2003
Abstract :
PubMedSearch : Wen_2003_Hum.Mol.Genet_12_1131
PubMedID: 12719377
Gene_locus related to this paper: human-LIPI

Title : DNA polymorphisms of lipase related genes - Cao_2003_J.Hum.Genet_48_443
Author(s) : Cao H , Hegele RA
Ref : J Hum Genet , 48 :443 , 2003
Abstract :
PubMedSearch : Cao_2003_J.Hum.Genet_48_443
PubMedID: 12898288

Title : Characterization of a novel mutation causing hepatic lipase deficiency among French Canadians - Ruel_2003_J.Lipid.Res_44_1508
Author(s) : Ruel IL , Couture P , Gagne C , Deshaies Y , Simard J , Hegele RA , Lamarche B
Ref : J Lipid Res , 44 :1508 , 2003
Abstract :
PubMedSearch : Ruel_2003_J.Lipid.Res_44_1508
PubMedID: 12777476
Gene_locus related to this paper: human-LIPC

Title : Polymorphisms in the gene encoding phosphatidylserine-specific phospholipase A1 ( PSPLA1) - Wang_2002_J.Hum.Genet_47_611
Author(s) : Wang J , Wen XY , Stewart AK , Hegele RA
Ref : J Hum Genet , 47 :611 , 2002
Abstract :
PubMedSearch : Wang_2002_J.Hum.Genet_47_611
PubMedID: 12436198

Title : Polymorphisms in PNLIP, encoding pancreatic lipase, and associations with metabolic traits - Hegele_2001_J.Hum.Genet_46_320
Author(s) : Hegele RA , Ramdath DD , Ban MR , Carruthers MN , Carrington CV , Cao H
Ref : J Hum Genet , 46 :320 , 2001
Abstract :
PubMedSearch : Hegele_2001_J.Hum.Genet_46_320
PubMedID: 11393534

Title : Absence of association between genetic variation in the LIPC gene promoter and plasma lipoproteins in three Canadian populations - Hegele_1999_Atherosclerosis_146_153
Author(s) : Hegele RA , Harris SB , Brunt JH , Young TK , Hanley AJ , Zinman B , Connelly PW
Ref : Atherosclerosis , 146 :153 , 1999
Abstract :
PubMedSearch : Hegele_1999_Atherosclerosis_146_153
PubMedID: 10487498

Title : Atorvastatin in the management of an index patient with complete hepatic lipase deficiency -
Author(s) : Hegele RA , Little JA , Connelly PW
Ref : Atherosclerosis , 143 :219 , 1999
PubMedID: 10208500

Title : Elevated LDL triglyceride concentrations in subjects heterozygous for the hepatic lipase S267F variant - Hegele_1998_Arterioscler.Thromb.Vasc.Biol_18_1212
Author(s) : Hegele RA , Breckenridge WC , Cox DW , Maguire GF , Little JA , Connelly PW
Ref : Arterioscler Thromb Vasc Biol , 18 :1212 , 1998
Abstract :
PubMedSearch : Hegele_1998_Arterioscler.Thromb.Vasc.Biol_18_1212
PubMedID: 9714127

Title : Beta-VLDL in hepatic lipase deficiency induces apoE-mediated cholesterol ester accumulation in macrophages - Huff_1993_Arterioscler.Thromb_13_1282
Author(s) : Huff MW , Sawyez CG , Connelly PW , Maguire GF , Little JA , Hegele RA
Ref : Arterioscler Thromb , 13 :1282 , 1993
Abstract :
PubMedSearch : Huff_1993_Arterioscler.Thromb_13_1282
PubMedID: 8364012

Title : Hepatic lipase deficiency. Clinical, biochemical, and molecular genetic characteristics - Hegele_1993_Arterioscler.Thromb_13_720
Author(s) : Hegele RA , Little JA , Vezina C , Maguire GF , Tu L , Wolever TS , Jenkins DJ , Connelly PW
Ref : Arterioscler Thromb , 13 :720 , 1993
Abstract :
PubMedSearch : Hegele_1993_Arterioscler.Thromb_13_720
PubMedID: 8485124

Title : Human hepatic lipase mutations and polymorphisms - Hegele_1992_Hum.Mutat_1_320
Author(s) : Hegele RA , Tu L , Connelly PW
Ref : Hum Mutat , 1 :320 , 1992
Abstract :
PubMedSearch : Hegele_1992_Hum.Mutat_1_320
PubMedID: 1301939

Title : Compound heterozygosity for mutant hepatic lipase in familial hepatic lipase deficiency - Hegele_1991_Biochem.Biophys.Res.Commun_179_78
Author(s) : Hegele RA , Little JA , Connelly PW
Ref : Biochemical & Biophysical Research Communications , 179 :78 , 1991
Abstract :
PubMedSearch : Hegele_1991_Biochem.Biophys.Res.Commun_179_78
PubMedID: 1883393

Title : A hepatic lipase gene mutation associated with heritable lipolytic deficiency - Hegele_1991_J.Clin.Endocrinol.Metab_72_730
Author(s) : Hegele RA , Vezina C , Moorjani S , Lupien PJ , Gagne C , Brun LD , Little JA , Connelly PW
Ref : J Clinical Endocrinology Metab , 72 :730 , 1991
Abstract :
PubMedSearch : Hegele_1991_J.Clin.Endocrinol.Metab_72_730
PubMedID: 1671786