human-LIPI

Homo sapiens (Human) membrane-associated phosphatidic acid-selective phospholipase a1 beta mPA-PLA1 beta (LPD lipase) Cancer/testis antigen 17 CT17

Comment

Wen et al. (2003) identified 2 Caucasian hypertriglyceridemic individuals who were heterozygous for a G-to-A transition at nucleotide 164 of the LIPI gene, resulting in cys55-to-tyr (C55Y\; 609252.0001) substitution. They identified 2 other coding SNPs that were associated with variation in plasma HDL cholesterol in independent normolipidemic populations

Relationship

Family : Phospholipase

Block : L

Position in NCBI Life Tree : Homo sapiens

(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)

> cellular organisms N E > Eukaryota N E > Opisthokonta N E > Metazoa N E > Eumetazoa N E > Bilateria N E > Deuterostomia N E > Chordata N E > Craniata N E > Vertebrata N E > Gnathostomata N E > Teleostomi N E > Euteleostomi N E > Sarcopterygii N E > Dipnotetrapodomorpha N E > Tetrapoda N E > Amniota N E > Mammalia N E > Theria N E > Eutheria N E > Boreoeutheria N E > Euarchontoglires N E > Primates N E > Haplorrhini N E > Simiiformes N E > Catarrhini N E > Hominoidea N E > Hominidae N E > Homininae N E > Homo N E > Homo sapiens N E

Molecular evidence

No mutation

No structure

No kinetic

No substrate

No inhibitor

Sequence

Peptide

MRVYIFLCLM CWVRSDNKRP CLEFSQLSVK DSFRDLFIPR IETILMMYTR NNLNCAEPLF EQNNSLNVNF NTQKKTVWLI HGYRPVGSIP LWLQNFVRIL LNEEDMNVIV VDWSRGATTF IYNRAVKNTR KVAVSLSVHI KNLLKHGASL DNFHFIGVSL GAHISGFVGK IFHGQLGRIT GLDPAGPRFS RKPPYSRLDY TDAKFVDVIH SDSNGLGIQE PLGHIDFYPN GGNKQPGCPK SIFSGIQFIK CNHQRAVHLF MASLETNCNF ISFPCRSYKD YKTSLCVDCD CFKEKSCPRL GYQAKLFKGV LKERMEGRPL RTTVFLDTSG TYPFCTYYFV LSIIVPDKTM MDGSFSFKLL NQLGMIEEPR LYEKNKPFYK LQEVKILAQF YNDFVNISSI GLTYFQSSNL QCSTCTYKIQ RLMLKSLTYP ERPPLCRYNI VLKDREEVFL NPNTCTPKNT

References (4)

Title : DNA microarrays reveal relationship of Ewing family tumors to both endothelial and fetal neural crest-derived cells and define novel targets - Staege_2004_Cancer.Res_64_8213
Author(s) : Staege MS , Hutter C , Neumann I , Foja S , Hattenhorst UE , Hansen G , Afar D , Burdach SE
Ref : Cancer Research , 64 :8213 , 2004
PubMedID: 15548687
Gene_locus related to this paper: human-LIPI

Title : Biochemical and molecular characterization of two phosphatidic acid-selective phospholipase A1s, mPA-PLA1alpha and mPA-PLA1beta - Hiramatsu_2003_J.Biol.Chem_278_49438
Author(s) : Hiramatsu T , Sonoda H , Takanezawa Y , Morikawa R , Ishida M , Kasahara K , Sanai Y , Taguchi R , Aoki J , Arai H
Ref : Journal of Biological Chemistry , 278 :49438 , 2003
PubMedID: 12963729
Gene_locus related to this paper: human-LIPI

Title : Identification of a novel lipase gene mutated in lpd mice with hypertriglyceridemia and associated with dyslipidemia in humans - Wen_2003_Hum.Mol.Genet_12_1131
Author(s) : Wen XY , Hegele RA , Wang J , Wang DY , Cheung J , Wilson M , Yahyapour M , Bai Y , Zhuang L , Skaug J , Young TK , Connelly PW , Koop BF , Tsui LC , Stewart AK
Ref : Hum Mol Genet , 12 :1131 , 2003
PubMedID: 12719377
Gene_locus related to this paper: human-LIPI