Howell SA

Title : Design of a potent, selective and brain penetrant inhibitor of Wnt-deactivating enzyme Notum by optimization of a crystallographic fragment hit - Willis_2022_J.Med.Chem_65_7212

Author(s) : Willis NJ , Mahy W , Sipthorp J , Zhao Y , Woodward HL , Atkinson BN , Bayle ED , Svensson F , Frew S , Jeganathan F , Monaghan A , Benvegnu S , Jolly S , Vecchia L , Ruza RR , Kjaer S , Howell SA , Snidjers AP , Bictash M , Salinas PC , Vincent JP , Jones EY , Whiting P , Fish PV

Ref : Journal of Medicinal Chemistry , 65 :7212 , 2022

Abstract :

PubMedSearch : Willis_2022_J.Med.Chem_65_7212

PubMedID: 35536179

Gene_locus related to this paper: human-NOTUM

Title : Notum deacylates Wnt proteins to suppress signalling activity - Kakugawa_2015_Nature_519_187

Author(s) : Kakugawa S , Langton PF , Zebisch M , Howell SA , Chang TH , Liu Y , Feizi T , Bineva G , O'Reilly N , Snijders AP , Jones EY , Vincent JP

Ref : Nature , 519 :187 , 2015

Abstract :

PubMedSearch : Kakugawa_2015_Nature_519_187

PubMedID: 25731175

Gene_locus related to this paper: drome-q9vux3 , human-NOTUM

Howell SA

References (2)

1. Design of a potent, selective and brain penetrant inhibitor of Wnt-deactivating enzyme Notum by optimization of a crystallographic fragment hit - Willis_2022_J.Med.Chem_65_7212

2. Notum deacylates Wnt proteins to suppress signalling activity - Kakugawa_2015_Nature_519_187