Jolly S

Title : Design of a potent, selective and brain penetrant inhibitor of Wnt-deactivating enzyme Notum by optimization of a crystallographic fragment hit - Willis_2022_J.Med.Chem_65_7212

Author(s) : Willis NJ , Mahy W , Sipthorp J , Zhao Y , Woodward HL , Atkinson BN , Bayle ED , Svensson F , Frew S , Jeganathan F , Monaghan A , Benvegnu S , Jolly S , Vecchia L , Ruza RR , Kjaer S , Howell SA , Snidjers AP , Bictash M , Salinas PC , Vincent JP , Jones EY , Whiting P , Fish PV

Ref : Journal of Medicinal Chemistry , 65 :7212 , 2022

Abstract :

PubMedSearch : Willis_2022_J.Med.Chem_65_7212

PubMedID: 35536179

Gene_locus related to this paper: human-NOTUM

Title : Small-molecule inhibitors of carboxylesterase Notum - Zhao_2021_Future.Med.Chem__

Author(s) : Zhao Y , Jolly S , Benvegnu S , Jones EY , Fish PV

Ref : Future Med Chem , : , 2021

Abstract :

PubMedSearch : Zhao_2021_Future.Med.Chem__

PubMedID: 33882714

Gene_locus related to this paper: human-NOTUM

Jolly S

References (2)

1. Design of a potent, selective and brain penetrant inhibitor of Wnt-deactivating enzyme Notum by optimization of a crystallographic fragment hit - Willis_2022_J.Med.Chem_65_7212

2. Small-molecule inhibitors of carboxylesterase Notum - Zhao_2021_Future.Med.Chem__