Full name : Johnson Martin Keith
First name : Martin Keith
Mail : Consultant Toxicologist, c\/o MRC Toxicology Unit, Hodgkin Building, University of Leicester, Lancaster Road, P.O. Box 138, Leicester LEI 9HN
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Country : United Kingdom
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Comment
Dr. Martin Keith Johnson, born in 1930, died in Banstead, Surrey on the 9th November 2018. Dr. Johnson was a founder member of the British Toxicology Society.In the early years of his carrier he worked in the Biochemical Mechanisms Group run by Dr Norman Aldridge. He discovered the neuropathy target esterase (NTE) as an enzyme activity, inhibited by low concentrations of the neuropathic OP, mipafox, but resistant to an AChE-directed OP, paraoxon. A paper by Ted Lock, Andrew Smith and Paul Glynn retraces his achievements Obituary
| Title : The Potential Value of beta-Amyloid Imaging for the Diagnosis and Management of Dementia: A Survey of Clinicians - Zhong_2017_Alzheimer.Dis.Assoc.Disord_31_27 |
| Author(s) : Zhong Y , Karlawish J , Johnson MK , Neumann PJ , Cohen JT |
| Ref : Alzheimer Disease & Associated Disorders , 31 :27 , 2017 |
| Abstract : |
| PubMedSearch : Zhong_2017_Alzheimer.Dis.Assoc.Disord_31_27 |
| PubMedID: 27819845 |
| Title : Toxicological assessment of isomeric pesticides: a strategy for testing of chiral organophosphorus (OP) compounds for delayed polyneuropathy in a regulatory setting - Battershill_2004_Food.Chem.Toxicol_42_1279 |
| Author(s) : Battershill JM , Edwards PM , Johnson MK |
| Ref : Food & Chemical Toxicology , 42 :1279 , 2004 |
| Abstract : |
| PubMedSearch : Battershill_2004_Food.Chem.Toxicol_42_1279 |
| PubMedID: 15207378 |
| Title : W. Norman Aldridge - Johnson_2001_Toxicol.Sci_59_3 |
| Author(s) : Johnson MK |
| Ref : Toxicol Sci , 59 :3 , 2001 |
| Abstract : |
| PubMedSearch : Johnson_2001_Toxicol.Sci_59_3 |
| PubMedID: |
| Title : Identification of acylpeptide hydrolase as a sensitive site for reaction with organophosphorus compounds and a potential target for cognitive enhancing drugs - Richards_2000_Mol.Pharmacol_58_577 |
| Author(s) : Richards PG , Johnson MK , Ray DE |
| Ref : Molecular Pharmacology , 58 :577 , 2000 |
| Abstract : |
| PubMedSearch : Richards_2000_Mol.Pharmacol_58_577 |
| PubMedID: 10953051 |
| Title : Delayed neuropathy in pigs induced by isofenphos - Shaw_1995_Vet.Rec_136_95 |
| Author(s) : Shaw IC , Parker RM , Porter S , Quick MP , Lamont MH , Patel RK , Norman IM , Johnson MK |
| Ref : Vet Rec , 136 :95 , 1995 |
| Abstract : |
| PubMedSearch : Shaw_1995_Vet.Rec_136_95 |
| PubMedID: 7740724 |
| Title : Neuropathy target esterase (NTE) and organophosphorus-induced delayed polyneuropathy (OPIDP): recent advances - Johnson_1995_Toxicol.Lett_82-83_459 |
| Author(s) : Johnson MK , Glynn P |
| Ref : Toxicol Lett , 82-83 :459 , 1995 |
| Abstract : |
| PubMedSearch : Johnson_1995_Toxicol.Lett_82-83_459 |
| PubMedID: 8597094 |
| Title : Synthesis and characterization of a biotinylated organophosphorus ester for detection and affinity purification of a brain serine esterase: neuropathy target esterase - Glynn_1994_Biochem.J_301 ( Pt 2)_551 |
| Author(s) : Glynn P , Read DJ , Guo R , Wylie S , Johnson MK |
| Ref : Biochemical Journal , 301 ( Pt 2) :551 , 1994 |
| Abstract : |
| PubMedSearch : Glynn_1994_Biochem.J_301 ( Pt 2)_551 |
| PubMedID: 8043002 |
| Title : Prophylaxis against and promotion of organophosphate-induced delayed neuropathy by phenyl di-n-pentylphosphinate - Johnson_1993_Chem.Biol.Interact_87_449 |
| Author(s) : Johnson MK , Read DJ |
| Ref : Chemico-Biological Interactions , 87 :449 , 1993 |
| Abstract : |
| PubMedSearch : Johnson_1993_Chem.Biol.Interact_87_449 |
| PubMedID: 8344002 |
| Title : Hydrolysis of some organophosphorus dichlorophenyl esters by hen brain homogenates and rabbit serum compared with hydrolysis of paraoxon - Reiner_1993_Chem.Biol.Interact_87_127 |
| Author(s) : Reiner E , Johnson MK , Jokanovic M |
| Ref : Chemico-Biological Interactions , 87 :127 , 1993 |
| Abstract : |
| PubMedSearch : Reiner_1993_Chem.Biol.Interact_87_127 |
| PubMedID: 8393734 |
| Title : Reactivation of phosphorodiamidated acetylcholinesterase and neuropathy target esterase by treatment of inhibited enzyme with potassium fluoride - Milatovic_1993_Chem.Biol.Interact_87_425 |
| Author(s) : Milatovic D , Johnson MK |
| Ref : Chemico-Biological Interactions , 87 :425 , 1993 |
| Abstract : |
| PubMedSearch : Milatovic_1993_Chem.Biol.Interact_87_425 |
| PubMedID: 8343998 |
| Title : Interactions in vitro of some organophosphoramidates with neuropathy target esterase and acetylcholinesterase of hen brain - Jokanovic_1993_J.Biochem.Toxicol_8_19 |
| Author(s) : Jokanovic M , Johnson MK |
| Ref : Journal of Biochemical Toxicology , 8 :19 , 1993 |
| Abstract : |
| PubMedSearch : Jokanovic_1993_J.Biochem.Toxicol_8_19 |
| PubMedID: 8492300 |
| Title : Molecular characterisation of neuropathy target esterase: proteolysis of the [3H]DFP-labelled polypeptide - Glynn_1993_Chem.Biol.Interact_87_361 |
| Author(s) : Glynn P , Ruffer-Turner M , Read D , Wylie S , Johnson MK |
| Ref : Chemico-Biological Interactions , 87 :361 , 1993 |
| Abstract : |
| PubMedSearch : Glynn_1993_Chem.Biol.Interact_87_361 |
| PubMedID: 8343993 |
| Title : Symposium introduction: retrospect and prospects for neuropathy target esterase (NTE) and the delayed polyneuropathy (OPIDP) induced by some organophosphorus esters - Johnson_1993_Chem.Biol.Interact_87_339 |
| Author(s) : Johnson MK |
| Ref : Chemico-Biological Interactions , 87 :339 , 1993 |
| Abstract : |
| PubMedSearch : Johnson_1993_Chem.Biol.Interact_87_339 |
| PubMedID: 8343991 |
| Title : Screening of O-ethyl O-4-nitrophenyl phosphoramidate (ENPP) for delayed neuropathic potential - Johnson_1993_Chem.Biol.Interact_87_439 |
| Author(s) : Johnson MK , Read DJ |
| Ref : Chemico-Biological Interactions , 87 :439 , 1993 |
| Abstract : |
| PubMedSearch : Johnson_1993_Chem.Biol.Interact_87_439 |
| PubMedID: 8344000 |
| Title : Stereo-specific degradation of the R-(+) isomer of O-n-hexyl-S-methylphosphorothioamidate catalysed by rabbit serum - Johnson_1993_Chem.Biol.Interact_87_133 |
| Author(s) : Johnson MK , Read DJ |
| Ref : Chemico-Biological Interactions , 87 :133 , 1993 |
| Abstract : |
| PubMedSearch : Johnson_1993_Chem.Biol.Interact_87_133 |
| PubMedID: 8343972 |
| Title : The R-(+)isomer of O-n-hexyl S-methyl phosphorothioamidate causes delayed neuropathy in hens after generation of a form of inhibited neuropathy target esterase (NTE) which can be reactivated ex vivo - Johnson_1993_Chem.Biol.Interact_87_443 |
| Author(s) : Johnson MK , Safi JM |
| Ref : Chemico-Biological Interactions , 87 :443 , 1993 |
| Abstract : |
| PubMedSearch : Johnson_1993_Chem.Biol.Interact_87_443 |
| PubMedID: 8344001 |
| Title : Pralidoxime for organophosphorus poisoning - |
| Author(s) : Johnson MK , Vale JA , Marrs TC , Meredith TJ |
| Ref : Lancet , 340 :64 , 1992 |
| PubMedID: 1351653 |
| Title : Anomalous biochemical responses in tests of the delayed neuropathic potential of methamidophos (O,S-dimethyl phosphorothioamidate), its resolved isomers and of some higher O-alkyl homologues - Johnson_1991_Arch.Toxicol_65_618 |
| Author(s) : Johnson MK , Vilanova E , Read DJ |
| Ref : Archives of Toxicology , 65 :618 , 1991 |
| Abstract : |
| PubMedSearch : Johnson_1991_Arch.Toxicol_65_618 |
| PubMedID: 1660708 |
| Title : Delayed neuropathy and acute toxicity studies with pirimiphos-methyl in the hen - Lock_1990_J.Appl.Toxicol_10_17 |
| Author(s) : Lock EA , Johnson MK |
| Ref : Journal of Applied Toxicology , 10 :17 , 1990 |
| Abstract : |
| PubMedSearch : Lock_1990_J.Appl.Toxicol_10_17 |
| PubMedID: 2335708 |
| Title : Biochemical and clinical tests of the delayed neuropathic potential of some O-alkyl O-dichlorophenyl phosphoramidate analogues of methamidophos (O,S-dimethyl phosphorothioamidate) - Johnson_1989_Toxicology_54_89 |
| Author(s) : Johnson MK , Vilanova E , Read DJ |
| Ref : Toxicology , 54 :89 , 1989 |
| Abstract : |
| PubMedSearch : Johnson_1989_Toxicology_54_89 |
| PubMedID: 2536970 |
| Title : Degradation by rat tissues in vitro of organophosphorus esters which inhibit cholinesterase - Pla_1989_Biochem.Pharmacol_38_1527 |
| Author(s) : Pla A , Johnson MK |
| Ref : Biochemical Pharmacology , 38 :1527 , 1989 |
| Abstract : |
| PubMedSearch : Pla_1989_Biochem.Pharmacol_38_1527 |
| PubMedID: 2719724 |
| Title : Interaction of some unsubstituted phosphoramidate analogs of methamidophos (O,S-dimethyl phosphorothioamidate) with acetylcholinesterase and neuropathy target esterase of hen brain - Vilanova_1987_Pestic.Biochem.Physiol_28_224 |
| Author(s) : Vilanova E , Johnson MK , Vicedo JL |
| Ref : Pesticide Biochemistry and Physiology , 28 :224 , 1987 |
| Abstract : |
| PubMedSearch : Vilanova_1987_Pestic.Biochem.Physiol_28_224 |
| PubMedID: |
| Title : Central-peripheral delayed neuropathy caused by diisopropyl phosphorofluoridate (DFP): segregation of peripheral nerve and spinal cord effects using biochemical, clinical, and morphological criteria - Lotti_1987_Toxicol.Appl.Pharmacol_88_87 |
| Author(s) : Lotti M , Caroldi S , Moretto A , Johnson MK , Fish CJ , Gopinath C , Roberts NL |
| Ref : Toxicol Appl Pharmacol , 88 :87 , 1987 |
| Abstract : |
| PubMedSearch : Lotti_1987_Toxicol.Appl.Pharmacol_88_87 |
| PubMedID: 3564033 |
| Title : The effect of steric factors on the interaction of some phenylphosphonates with acetylcholinesterase and neuropathy target esterase of hen brain - Johnson_1986_Pestic.Biochem.Physiol_25_133 |
| Author(s) : Johnson MK , Read DJ , Yoshikawa H |
| Ref : Pesticide Biochemistry and Physiology , 25 :133 , 1986 |
| Abstract : |
| PubMedSearch : Johnson_1986_Pestic.Biochem.Physiol_25_133 |
| PubMedID: |
| Title : Poster 73. Interaction of the resolved isomers of soman with chicken brain acetylcholinesterase and neuropathy target esterase - |
| Author(s) : Johnson MK , Read DJ , Benschop HP |
| Ref : In: Cholinesterases, fundamental and applied aspects : proceedings of the Second International Meeting on Cholinesterases , (Brzin M, Barnard EA, Sket D, Eds) De Gruyter , 1984 |
| PubMedID: |
| Title : The aging reaction of inhibited neuropathy target esterase - fundamental studies and toxicological significance - |
| Author(s) : Johnson MK |
| Ref : In: Cholinesterases, fundamental and applied aspects : proceedings of the Second International Meeting on Cholinesterases , (Brzin M, Barnard EA, Sket D, Eds) De Gruyter :463 , 1984 |
| PubMedID: |
| Title : Interaction of some trialkyl phosphorothiolates with acetylcholinesterase. Characterization of inhibition, aging and reactivation - Clothier_1981_Biochim.Biophys.Acta_660_306 |
| Author(s) : Clothier B , Johnson MK , Reiner E |
| Ref : Biochimica & Biophysica Acta , 660 :306 , 1981 |
| Abstract : |
| PubMedSearch : Clothier_1981_Biochim.Biophys.Acta_660_306 |
| PubMedID: 7284405 |
| Title : Initiation of organophosphate neurotoxicity [letter] - |
| Author(s) : Johnson MK |
| Ref : Toxicol Appl Pharmacol , 61 :480 , 1981 |
| PubMedID: 7330886 |
| Title : Repeated small doses of a neurotoxic organophosphate. Monitoring of neurotoxic esterase in brain and spinal cord - Lotti_1980_Arch.Toxicol_45_263 |
| Author(s) : Lotti M , Johnson MK |
| Ref : Archives of Toxicology , 45 :263 , 1980 |
| Abstract : |
| PubMedSearch : Lotti_1980_Arch.Toxicol_45_263 |
| PubMedID: 7447700 |
| Title : Delayed neurotoxicity caused by chronic feeding of organophosphates requires a high-point of inhibition of neurotoxic esterase - Johnson_1980_Toxicol.Lett_5_99 |
| Author(s) : Johnson MK , Lotti M |
| Ref : Toxicol Lett , 5 :99 , 1980 |
| Abstract : |
| PubMedSearch : Johnson_1980_Toxicol.Lett_5_99 |
| PubMedID: 7376206 |
| Title : Biochemical events in delayed neurotoxicity: is aging of chymotrypsin inhibited by saligenin cyclic phosphates a model for aging of neurotoxic esterase? - Johnson_1980_Toxicol.Lett_5_95 |
| Author(s) : Johnson MK , Clothier B |
| Ref : Toxicol Lett , 5 :95 , 1980 |
| Abstract : |
| PubMedSearch : Johnson_1980_Toxicol.Lett_5_95 |
| PubMedID: 7376205 |
| Title : Neurotoxic esterase in human nervous tissue - |
| Author(s) : Lotti M , Johnson MK |
| Ref : Journal of Neurochemistry , 34 :747 , 1980 |
| PubMedID: 7354348 |
| Title : Neurotoxicity of organophosphorus pesticides: predictions can be based on in vitro studies with hen and human enzymes - Lotti_1978_Arch.Toxicol_41_215 |
| Author(s) : Lotti M , Johnson MK |
| Ref : Archives of Toxicology , 41 :215 , 1978 |
| Abstract : |
| PubMedSearch : Lotti_1978_Arch.Toxicol_41_215 |
| PubMedID: 736792 |
| Title : Clinical and toxicological investigations of a case of delayed neuropathy in man after acute poisoning by an organophosphorus pesticide - Hierons_1978_Arch.Toxicol_40_279 |
| Author(s) : Hierons R , Johnson MK |
| Ref : Archives of Toxicology , 40 :279 , 1978 |
| Abstract : |
| PubMedSearch : Hierons_1978_Arch.Toxicol_40_279 |
| PubMedID: 358947 |
| Title : The anomalous behaviour of dimethyl phosphates in the biochemical test for delayed neurotoxicity - Johnson_1978_Arch.Toxicol_41_107 |
| Author(s) : Johnson MK |
| Ref : Archives of Toxicology , 41 :107 , 1978 |
| Abstract : |
| PubMedSearch : Johnson_1978_Arch.Toxicol_41_107 |
| PubMedID: 718419 |
| Title : Improved assay of neurotoxic esterase for screening organophosphates for delayed neurotoxicity potential - Johnson_1977_Arch.Toxicol_37_113 |
| Author(s) : Johnson MK |
| Ref : Archives of Toxicology , 37 :113 , 1977 |
| Abstract : |
| PubMedSearch : Johnson_1977_Arch.Toxicol_37_113 |
| PubMedID: 577680 |
| Title : Side effects of organophosphorus compounds: delayed neurotoxicity - |
| Author(s) : Aldridge WN , Johnson MK |
| Ref : Bulletin of the World Health Organization , 44 :259 , 1971 |
| PubMedID: 5315346 |
| Title : Studies on delayed neurotoxicity produced by some organophosphorus compounds - |
| Author(s) : Aldridge WN , Barnes JM , Johnson MK |
| Ref : Annals of the New York Academy of Sciences , 160 :314 , 1969 |
| PubMedID: 4896090 |
| Title : Cholinesterase, succinic dehydrogenase, nucleic acids, esterase and glutathione reductase in sub-cellular fractions from rat brain - |
| Author(s) : Aldridge WN , Johnson MK |
| Ref : Biochemical Journal , 73 :270 , 1959 |
| PubMedID: 13792488 |