| Title : Structure-Based Optimization of Coumestan Derivatives as Polyketide Synthase 13-Thioesterase(Pks13-TE) Inhibitors with Improved hERG Profiles for Mycobacterium tuberculosis Treatment - Zhang_2022_J.Med.Chem_65_13240 |
| Author(s) : Zhang W , Lun S , Wang SS , Cai YP , Yang F , Tang J , Bishai WR , Yu LF |
| Ref : Journal of Medicinal Chemistry , 65 :13240 , 2022 |
| Abstract : |
| PubMedSearch : Zhang_2022_J.Med.Chem_65_13240 |
| PubMedID: 36174223 |
| Gene_locus related to this paper: myctu-PKS13 |
| Title : Design and synthesis of mycobacterial pks13 inhibitors: Conformationally rigid tetracyclic molecules - Zhang_2021_Eur.J.Med.Chem_213_113202 |
| Author(s) : Zhang W , Liu LL , Lun S , Wang SS , Xiao S , Gunosewoyo H , Yang F , Tang J , Bishai WR , Yu LF |
| Ref : Eur Journal of Medicinal Chemistry , 213 :113202 , 2021 |
| Abstract : |
| PubMedSearch : Zhang_2021_Eur.J.Med.Chem_213_113202 |
| PubMedID: 33516983 |
| Gene_locus related to this paper: myctu-PKS13 |
| Title : Identification of Novel Coumestan Derivatives as Polyketide Synthase 13 Inhibitors against Mycobacterium tuberculosis. Part II - Zhang_2019_J.Med.Chem_62_3575 |
| Author(s) : Zhang W , Lun S , Liu LL , Xiao S , Duan G , Gunosewoyo H , Yang F , Tang J , Bishai WR , Yu LF |
| Ref : Journal of Medicinal Chemistry , 62 :3575 , 2019 |
| Abstract : |
| PubMedSearch : Zhang_2019_J.Med.Chem_62_3575 |
| PubMedID: 30875203 |
| Gene_locus related to this paper: myctu-PKS13 |
| Title : Identification of Novel Coumestan Derivatives as Polyketide Synthase 13 Inhibitors against Mycobacterium tuberculosis - Zhang_2018_J.Med.Chem_61_791 |
| Author(s) : Zhang W , Lun S , Wang SH , Jiang XW , Yang F , Tang J , Manson AL , Earl AM , Gunosewoyo H , Bishai WR , Yu LF |
| Ref : Journal of Medicinal Chemistry , 61 :791 , 2018 |
| Abstract : |
| PubMedSearch : Zhang_2018_J.Med.Chem_61_791 |
| PubMedID: 29328655 |
| Gene_locus related to this paper: myctu-PKS13 |
| Title : Synthesis and biological evaluation of novel hybrids of highly potent and selective alpha4beta2-Nicotinic acetylcholine receptor (nAChR) partial agonists - Zhang_2016_Eur.J.Med.Chem_124_689 |
| Author(s) : Zhang HK , Eaton JB , Fedolak A , Gunosewoyo H , Onajole OK , Brunner D , Lukas RJ , Yu LF , Kozikowski AP |
| Ref : Eur Journal of Medicinal Chemistry , 124 :689 , 2016 |
| Abstract : |
| PubMedSearch : Zhang_2016_Eur.J.Med.Chem_124_689 |
| PubMedID: 27639361 |
| Title : Chemistry and behavioral studies identify chiral cyclopropanes as selective alpha4beta2-nicotinic acetylcholine receptor partial agonists exhibiting an antidepressant profile - Zhang_2012_J.Med.Chem_55_717 |
| Author(s) : Zhang H , Tuckmantel W , Eaton JB , Yuen PW , Yu LF , Bajjuri KM , Fedolak A , Wang D , Ghavami A , Caldarone B , Paterson NE , Lowe DA , Brunner D , Lukas RJ , Kozikowski AP |
| Ref : Journal of Medicinal Chemistry , 55 :717 , 2012 |
| Abstract : |
| PubMedSearch : Zhang_2012_J.Med.Chem_55_717 |
| PubMedID: 22171543 |
| Title : Discovery of isoxazole analogues of sazetidine-A as selective alpha4beta2-nicotinic acetylcholine receptor partial agonists for the treatment of depression - Liu_2011_J.Med.Chem_54_7280 |
| Author(s) : Liu J , Yu LF , Eaton JB , Caldarone B , Cavino K , Ruiz C , Terry M , Fedolak A , Wang D , Ghavami A , Lowe DA , Brunner D , Lukas RJ , Kozikowski AP |
| Ref : Journal of Medicinal Chemistry , 54 :7280 , 2011 |
| Abstract : |
| PubMedSearch : Liu_2011_J.Med.Chem_54_7280 |
| PubMedID: 21905669 |