Full name : Zhang Hai Yan
First name : Hai Yan
Mail : China State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences
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Country : China
Email : hzhang@simm.ac.cn
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| Title : EPRCN exerts neuroprotective function by regulating gut microbiota and restoring gut immune homeostasis in Alzheimer's disease model mice - Li_2025_J.Alzheimers.Dis__13872877251339762 |
| Author(s) : Li MJ , Lan MN , Du YX , Liu Y , Zhang HY , Guo M , Liu SW , Xia HY , Wu ZJ , Zheng HJ |
| Ref : J Alzheimers Dis , :13872877251339762 , 2025 |
| Abstract : |
| PubMedSearch : Li_2025_J.Alzheimers.Dis__13872877251339762 |
| PubMedID: 40325871 |
| Title : Lycofargesiines A-F, further Lycopodium alkaloids from the club moss Huperzia fargesii - Xiong_2019_Phytochemistry_162_183 |
| Author(s) : Xiong J , Meng WJ , Zhang HY , Zou Y , Wang WX , Wang XY , Yang QL , Osman EEA , Hu JF |
| Ref : Phytochemistry , 162 :183 , 2019 |
| Abstract : |
| PubMedSearch : Xiong_2019_Phytochemistry_162_183 |
| PubMedID: 30928888 |
| Title : Annotinolide F and lycoannotines A-I, further Lycopodium alkaloids from Lycopodium annotinum - Tang_2017_Phytochemistry_143_1 |
| Author(s) : Tang Y , Xiong J , Zou Y , Wang W , Huang C , Zhang HY , Hu JF |
| Ref : Phytochemistry , 143 :1 , 2017 |
| Abstract : |
| PubMedSearch : Tang_2017_Phytochemistry_143_1 |
| PubMedID: 28738241 |
| Title : Acetylcholinesterase-independent protective effects of huperzine A against iron overload-induced oxidative damage and aberrant iron metabolism signaling in rat cortical neurons - Tao_2016_Acta.Pharmacol.Sin_37_1391 |
| Author(s) : Tao LX , Huang XT , Chen YT , Tang XC , Zhang HY |
| Ref : Acta Pharmacol Sin , 37 :1391 , 2016 |
| Abstract : |
| PubMedSearch : Tao_2016_Acta.Pharmacol.Sin_37_1391 |
| PubMedID: 27498774 |
| Title : Carboxylesterase-mediated insecticide resistance: Quantitative increase induces broader metabolic resistance than qualitative change - Cui_2015_Pestic.Biochem.Physiol_121_88 |
| Author(s) : Cui F , Li MX , Chang HJ , Mao Y , Zhang HY , Lu LX , Yan SG , Lang ML , Liu L , Qiao CL |
| Ref : Pestic Biochem Physiol , 121 :88 , 2015 |
| Abstract : |
| PubMedSearch : Cui_2015_Pestic.Biochem.Physiol_121_88 |
| PubMedID: 26047115 |
| Title : Donepezil attenuates Abeta-associated mitochondrial dysfunction and reduces mitochondrial Abeta accumulation in vivo and in vitro - Ye_2015_Neuropharmacol_95_29 |
| Author(s) : Ye CY , Lei Y , Tang XC , Zhang HY |
| Ref : Neuropharmacology , 95 :29 , 2015 |
| Abstract : |
| PubMedSearch : Ye_2015_Neuropharmacol_95_29 |
| PubMedID: 25744714 |
| Title : Reducing iron in the brain: a novel pharmacologic mechanism of huperzine A in the treatment of Alzheimer's disease - Huang_2014_Neurobiol.Aging_35_1045 |
| Author(s) : Huang XT , Qian ZM , He X , Gong Q , Wu KC , Jiang LR , Lu LN , Zhu ZJ , Zhang HY , Yung WH , Ke Y |
| Ref : Neurobiology of Aging , 35 :1045 , 2014 |
| Abstract : |
| PubMedSearch : Huang_2014_Neurobiol.Aging_35_1045 |
| PubMedID: 24332448 |
| Title : Casuarinines A-J, Lycodine-Type Alkaloids from Lycopodiastrum casuarinoides - Tang_2013_J.Nat.Prod_76_1475 |
| Author(s) : Tang Y , Fu Y , Xiong J , Li M , Ma GL , Yang GX , Wei BG , Zhao Y , Zhang HY , Hu JF |
| Ref : Journal of Natural Products , 76 :1475 , 2013 |
| Abstract : |
| PubMedSearch : Tang_2013_J.Nat.Prod_76_1475 |
| PubMedID: 23941108 |
| Title : Huperzine A alleviates synaptic deficits and modulates amyloidogenic and nonamyloidogenic pathways in APPswe\/PS1dE9 transgenic mice - Wang_2012_J.Neurosci.Res_90_508 |
| Author(s) : Wang Y , Tang XC , Zhang HY |
| Ref : Journal of Neuroscience Research , 90 :508 , 2012 |
| Abstract : |
| PubMedSearch : Wang_2012_J.Neurosci.Res_90_508 |
| PubMedID: 22002568 |
| Title : New insights into huperzine A for the treatment of Alzheimer's disease - Zhang_2012_Acta.Pharmacol.Sin_33_1170 |
| Author(s) : Zhang HY |
| Ref : Acta Pharmacol Sin , 33 :1170 , 2012 |
| Abstract : |
| PubMedSearch : Zhang_2012_Acta.Pharmacol.Sin_33_1170 |
| PubMedID: 22941287 |
| Title : Concentrations of plasma metabolites, hormones, and mRNA abundance of adipose leptin and hormone-sensitive lipase in ketotic and nonketotic dairy cows - Xia_2012_J.Vet.Intern.Med_26_415 |
| Author(s) : Xia C , Wang Z , Xu C , Zhang HY |
| Ref : J Vet Intern Med , 26 :415 , 2012 |
| Abstract : |
| PubMedSearch : Xia_2012_J.Vet.Intern.Med_26_415 |
| PubMedID: 22296673 |
| Title : Huperzine a improves chronic inflammation and cognitive decline in rats with cerebral hypoperfusion - Wang_2010_J.Neurosci.Res_88_807 |
| Author(s) : Wang J , Zhang HY , Tang XC |
| Ref : Journal of Neuroscience Research , 88 :807 , 2010 |
| Abstract : |
| PubMedSearch : Wang_2010_J.Neurosci.Res_88_807 |
| PubMedID: 19795377 |
| Title : Novel 16-substituted bifunctional derivatives of huperzine B: multifunctional cholinesterase inhibitors - Shi_2009_Acta.Pharmacol.Sin_30_1195 |
| Author(s) : Shi YF , Zhang HY , Wang W , Fu Y , Xia Y , Tang XC , Bai DL , He XC |
| Ref : Acta Pharmacol Sin , 30 :1195 , 2009 |
| Abstract : |
| PubMedSearch : Shi_2009_Acta.Pharmacol.Sin_30_1195 |
| PubMedID: 19578388 |
| Title : Diagnosis and surgical treatment of isolated hypoganglionosis - Zhang_2008_World.J.Pediatr_4_295 |
| Author(s) : Zhang HY , Feng JX , Huang L , Wang G , Wei MF , Weng YZ |
| Ref : World J Pediatr , 4 :295 , 2008 |
| Abstract : |
| PubMedSearch : Zhang_2008_World.J.Pediatr_4_295 |
| PubMedID: 19104894 |
| Title : Potential therapeutic targets of huperzine A for Alzheimer's disease and vascular dementia - Zhang_2008_Chem.Biol.Interact_175_396 |
| Author(s) : Zhang HY , Zheng CY , Yan H , Wang ZF , Tang LL , Gao X , Tang XC |
| Ref : Chemico-Biological Interactions , 175 :396 , 2008 |
| Abstract : |
| PubMedSearch : Zhang_2008_Chem.Biol.Interact_175_396 |
| PubMedID: 18565502 |
| Title : Non-cholinergic effects of huperzine A: beyond inhibition of acetylcholinesterase - Zhang_2008_Cell.Mol.Neurobiol_28_173 |
| Author(s) : Zhang HY , Yan H , Tang XC |
| Ref : Cellular Molecular Neurobiology , 28 :173 , 2008 |
| Abstract : |
| PubMedSearch : Zhang_2008_Cell.Mol.Neurobiol_28_173 |
| PubMedID: 17657601 |
| Title : Huperzine A exhibits anti-inflammatory and neuroprotective effects in a rat model of transient focal cerebral ischemia - Wang_2008_J.Neurochem_106_1594 |
| Author(s) : Wang ZF , Wang J , Zhang HY , Tang XC |
| Ref : Journal of Neurochemistry , 106 :1594 , 2008 |
| Abstract : |
| PubMedSearch : Wang_2008_J.Neurochem_106_1594 |
| PubMedID: 18513368 |
| Title : R-stereopreference analysis of lipase Novozym 435 in kinetic resolution of flurbiprofen - Zhang_2007_Chirality_19_245 |
| Author(s) : Zhang HY , Wang X , Ching CB |
| Ref : Chirality , 19 :245 , 2007 |
| Abstract : |
| PubMedSearch : Zhang_2007_Chirality_19_245 |
| PubMedID: 17094073 |
| Title : Involvement of M1-muscarinic acetylcholine receptors, protein kinase C and mitogen-activated protein kinase in the effect of huperzine A on secretory amyloid precursor protein-alpha - Yan_2007_Neuroreport_18_689 |
| Author(s) : Yan H , Zhang HY , Tang XC |
| Ref : Neuroreport , 18 :689 , 2007 |
| Abstract : |
| PubMedSearch : Yan_2007_Neuroreport_18_689 |
| PubMedID: 17426600 |
| Title : Neuroprotective effects of huperzine A: new therapeutic targets for neurodegenerative disease - Zhang_2006_Trends.Pharmacol.Sci_27_619 |
| Author(s) : Zhang HY , Tang XC |
| Ref : Trends in Pharmacological Sciences , 27 :619 , 2006 |
| Abstract : |
| PubMedSearch : Zhang_2006_Trends.Pharmacol.Sci_27_619 |
| PubMedID: 17056129 |
| Title : Experimental optimization of enzymic kinetic resolution of racemic flurbiprofen - Zhang_2005_Biotechnol.Appl.Biochem_42_67 |
| Author(s) : Zhang HY , Wang X , Ching CB , Wu JC |
| Ref : Biotechnol Appl Biochem , 42 :67 , 2005 |
| Abstract : |
| PubMedSearch : Zhang_2005_Biotechnol.Appl.Biochem_42_67 |
| PubMedID: 15651979 |
| Title : One-compound-multiple-targets strategy to combat Alzheimer's disease - Zhang_2005_FEBS.Lett_579_5260 |
| Author(s) : Zhang HY |
| Ref : FEBS Letters , 579 :5260 , 2005 |
| Abstract : |
| PubMedSearch : Zhang_2005_FEBS.Lett_579_5260 |
| PubMedID: 16194540 |
| Title : Relationship between polymorphisms of genes encoding microsomal epoxide hydrolase and glutathione S-transferase P1 and chronic obstructive pulmonary disease - Xiao_2004_Chin.Med.J.(Engl)_117_661 |
| Author(s) : Xiao D , Wang C , Du MJ , Pang BS , Zhang HY , Xiao B , Liu JZ , Weng XZ , Su L , Christiani DC |
| Ref : Chinese Medical Journal (Engl) , 117 :661 , 2004 |
| Abstract : |
| PubMedSearch : Xiao_2004_Chin.Med.J.(Engl)_117_661 |
| PubMedID: 15161530 |
| Title : Apoptosis induced by beta-amyloid25-35 in acetylcholinesterase-overexpressing neuroblastoma cells - Zhang_2003_Acta.Pharmacol.Sin_24_853 |
| Author(s) : Zhang HY , Brimijoin S , Tang XC |
| Ref : Acta Pharmacol Sin , 24 :853 , 2003 |
| Abstract : |
| PubMedSearch : Zhang_2003_Acta.Pharmacol.Sin_24_853 |
| PubMedID: 12956931 |
| Title : [Association between polymorphisms in the microsomal epoxide hydrolase (mEH) gene and chronic obstructive pulmonary disease] - Xiao_2003_Zhonghua.Yi.Xue.Za.Zhi_83_1782 |
| Author(s) : Xiao D , Wang C , Du MJ , Pang BS , Zhang HY , Xiao B , Liu JZ , Weng XZ , Su L , Christiani DC |
| Ref : Zhonghua Yi Xue Za Zhi , 83 :1782 , 2003 |
| Abstract : |
| PubMedSearch : Xiao_2003_Zhonghua.Yi.Xue.Za.Zhi_83_1782 |
| PubMedID: 14642084 |
| Title : Huperzine A attenuates amyloid beta-peptide fragment 25-35-induced apoptosis in rat cortical neurons via inhibiting reactive oxygen species formation and caspase-3 activation - Xiao_2002_J.Neurosci.Res_67_30 |
| Author(s) : Xiao XQ , Zhang HY , Tang XC |
| Ref : Journal of Neuroscience Research , 67 :30 , 2002 |
| Abstract : |
| PubMedSearch : Xiao_2002_J.Neurosci.Res_67_30 |
| PubMedID: 11754078 |
| Title : Stereoselectivities of enantiomers of huperzine A in protection against beta-amyloid(25-35)-induced injury in PC12 and NG108-15 cells and cholinesterase inhibition in mice - Zhang_2002_Neurosci.Lett_317_143 |
| Author(s) : Zhang HY , Liang YQ , Tang XC , He XC , Bai DL |
| Ref : Neuroscience Letters , 317 :143 , 2002 |
| Abstract : |
| PubMedSearch : Zhang_2002_Neurosci.Lett_317_143 |
| PubMedID: 11755260 |
| Title : Huperzine A attenuates cognitive deficits and hippocampal neuronal damage after transient global ischemia in gerbils - Zhou_2001_Neurosci.Lett_313_137 |
| Author(s) : Zhou J , Zhang HY , Tang XC |
| Ref : Neuroscience Letters , 313 :137 , 2001 |
| Abstract : |
| PubMedSearch : Zhou_2001_Neurosci.Lett_313_137 |
| PubMedID: 11682146 |
| Title : Huperzine B, a novel acetylcholinesterase inhibitor, attenuates hydrogen peroxide induced injury in PC12 cells - Zhang_2000_Neurosci.Lett_292_41 |
| Author(s) : Zhang HY , Tang XC |
| Ref : Neuroscience Letters , 292 :41 , 2000 |
| Abstract : |
| PubMedSearch : Zhang_2000_Neurosci.Lett_292_41 |
| PubMedID: 10996445 |
| Title : Inhibitory effects of huperzine B on cholinesterase activity in mice - Liu_1999_Zhongguo.Yao.Li.Xue.Bao_20_141 |
| Author(s) : Liu J , Zhang HY , Wang LM , Tang XC |
| Ref : Zhongguo Yao Li Xue Bao , 20 :141 , 1999 |
| Abstract : |
| PubMedSearch : Liu_1999_Zhongguo.Yao.Li.Xue.Bao_20_141 |
| PubMedID: 10437161 |
| Title : Effects of synthetic (-)-huperzine A on cholinesterase activities and mouse water maze performance - Liu_1998_Zhongguo.Yao.Li.Xue.Bao_19_413 |
| Author(s) : Liu J , Zhang HY , Tang XC , Wang B , He XC , Bai DL |
| Ref : Acta Pharmacol Sin , 19 :413 , 1998 |
| Abstract : |
| PubMedSearch : Liu_1998_Zhongguo.Yao.Li.Xue.Bao_19_413 |
| PubMedID: 10375798 |